Nicotinamide riboside improves muscle mitochondrial biogenesis, satellite cell differentiation, and gut microbiota in a twin study
Lapatto, H. A., Kuusela, M., Heikkinen, A., Muniandy, M., van der Kolk, B. W., Gopalakrishnan, S., Pöllänen, N., Sandvik, M., Schmidt, M. S., Heinonen, S., Saari, S., Kuula, J., Hakkarainen, A., Tampio, J., Saarinen, T., Taskinen, M.-R., Lundbom, N., Groop, P.-H., Tiirola, M., . . . Pirinen, E. (2023). Nicotinamide riboside improves muscle mitochondrial biogenesis, satellite cell differentiation, and gut microbiota in a twin study. Science Advances, 9(2), Article eadd5163. https://doi.org/10.1126/sciadv.add5163
Julkaistu sarjassa
Science AdvancesTekijät
Päivämäärä
2023Oppiaine
ResurssiviisausyhteisöNanoscience CenterLiikuntalääketiedeYmpäristötiedeSchool of Resource WisdomNanoscience CenterSports and Exercise MedicineEnvironmental ScienceTekijänoikeudet
© 2023 the Authors
2023:126 | 2024:65 | 2025:4
Nicotinamide adenine dinucleotide (NAD+) precursor nicotinamide riboside (NR) has emerged as a promising compound to improve obesity-associated mitochondrial dysfunction and metabolic syndrome in mice. However, most short-term clinical trials conducted so far have not reported positive outcomes. Therefore, we aimed to determine whether long-term NR supplementation boosts mitochondrial biogenesis and metabolic health in humans. Twenty body mass index (BMI)–discordant monozygotic twin pairs were supplemented with an escalating dose of NR (250 to 1000 mg/day) for 5 months. NR improved systemic NAD+ metabolism, muscle mitochondrial number, myoblast differentiation, and gut microbiota composition in both cotwins. NR also showed a capacity to modulate epigenetic control of gene expression in muscle and adipose tissue in both cotwins. However, NR did not ameliorate adiposity or metabolic health. Overall, our results suggest that NR acts as a potent modifier of NAD+ metabolism, muscle mitochondrial biogenesis and stem cell function, gut microbiota, and DNA methylation in humans irrespective of BMI.
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Julkaisija
American Association for the Advancement of Science (AAAS)ISSN Hae Julkaisufoorumista
2375-2548Asiasanat
Julkaisu tutkimustietojärjestelmässä
https://converis.jyu.fi/converis/portal/detail/Publication/172653171
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This work was supported by Centre of Excellence funding from the Academy of Finland (#272376 to K.H.P. and #336823 to J.Ka.), Academy of Finland grants (286359, 314455, 335445, and Profi6 336449 to E.P.; 335443, 314383, 272376, and 266286 to K.H.P.; 308042 to S.P.; 308042 and 328685 to M.O.),Sigrid Jusélius Foundation (to K.H.P.), Finnish Medical Foundation (to H.A.K.L. and N.P.), Medical Society of Finland (to H.A.K.L.), Biomedicum Helsinki Foundation (to N.P.), Finnish Diabetes Research Foundation (to E.P.), Novo Nordisk Foundation (NNF20OC0060547, NNF17OC0027232, and NNF10OC1013354 to K.H.P.), Gyllenberg Foundation (to K.H.P.), Government Research Funds to Helsinki University Hospital (to K.H.P.), National Institutes of Health (R01HL147545 to C.B.), and Alfred E. Mann Family Foundation (to C.B.) ...Lisenssi
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