Intrinsic aerobic capacity governs the associations between gut microbiota composition and fat metabolism age-dependently in rat siblings
Pekkala, S., Lensu, S., Nokia, M., Vanhatalo, S., Koch, L. G., Britton, S. L., & Kainulainen, H. (2017). Intrinsic aerobic capacity governs the associations between gut microbiota composition and fat metabolism age-dependently in rat siblings. Physiological Genomics, 49(12), 733-746. https://doi.org/10.1152/physiolgenomics.00081.2017
Published inPhysiological Genomics
DisciplinePsykologiaLiikuntafysiologiaMonitieteinen aivotutkimuskeskusHyvinvoinnin tutkimuksen yhteisöPsychologyExercise PhysiologyCentre for Interdisciplinary Brain ResearchSchool of Wellbeing
© 2017 the American Physiological Society. This is a final draft version of an article whose final and definitive form has been published by the American Physiological Society. Published in this repository with the kind permission of the publisher.
Host genetic factors affecting the gut microbiome play an important role in obesity, yet limited attention has been paid on the host genetic factors linked to physical fitness in modifying the microbiome. This study determined whether sibling-matched pairs of rats selectively bred for high (HCR) and low (LCR) aerobic capacity differ in their microbiome age-dependently and which taxa associate with differential in metabolism. Several taxa in young adult rats (hereafter young) linked to inherited aerobic capacity, while in older adult (hereafter old) rats most of the differences between the lines associated with body weight. Despite the absence of weight differential between LCR and HCR when young, the LCR microbiome contained more Actinobacteria, Veillonellaceae, Coriobacteriaceae, Phascolarctobacterium, and Ruminococcus; taxa previously linked to obesity. This raises the question whether the microbiome contributes to the later development of obesity in LCR. Age-related differences were detected in almost all taxa in both rat lines. The young HCR measured higher for serum glycerol and free fatty-acids and lower for cholesterol, HDL, LDL, and triglycerides than LCR. The old HCR differed from the old LCR by lower LDL. Several metabolites, including LDL, are associated age and genetic background-dependently with the microbiome, which might explain the metabolic differences between the lines. While old lines did not differ in visceral adipose tissue gene expression, the young HCR expressed more inflammatory genes than LCR, and several taxa including Proteobacteria associated with these genes. In conclusion, intrinsic aerobic capacity governs the microbiome, which may influence body weight, metabolism, and gene expression. ...
PublisherAmerican Physiological Society
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- Liikuntatieteiden tiedekunta 
Related funder(s)Academy of Finland
Funding program(s)Academy Programme, AoF; Postdoctoral Researcher, AoF
Additional information about fundingThe study was financially supported by Academy of Finland Grant ID 274098 (to H. Kainulainen) and Grant ID 267719 (to S. Pekkala). The LCR-HCR rat model system was funded by National Institutes of Health Office of Research Infrastructure Programs Grant P40OD-021331 (to L. G. Koch and S. L. Britton).
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