The impact of maternal weight in pregnancy on glucose metabolism in non-diabetic offspring in late adulthood
Westberg, A. P., Kautiainen, H., Salonen, M. K., Kajantie, E., von Bonsdorff, M., & Eriksson, J. G. (2019). The impact of maternal weight in pregnancy on glucose metabolism in non-diabetic offspring in late adulthood. Diabetes Research and Clinical Practice, 158, Article 107926. https://doi.org/10.1016/j.diabres.2019.107926
Published inDiabetes Research and Clinical Practice
© 2019 Elsevier B.V.
Aims We aimed to examine the association between maternal adiposity and glucose metabolism in adult offspring without diabetes, simultaneous taking offspring own adiposity into account. Methods This longitudinal birth cohort study (Helsinki Birth Cohort Study) included 1,440 non-diabetic subjects examined at a mean age of 62 years. Subjects were divided into quartiles according to maternal body mass index (BMI). The impact of maternal BMI on offspring body composition was also studied. Results There were no differences in fasting glucose between the groups. In men, maternal BMI was inversely associated with mean 2-hour glucose concentration after a 75 g oral glucose tolerance test (p<0.001) and mean homeostatic model assessment of insulin resistance (HOMA-IR) (p=0.049). According to the subjects’ own BMI, high maternal BMI was associated with lower 2-hour glucose concentrations only in non-obese men and with lower HOMA-IR only in obese men. Maternal BMI was not associated with glucose concentrations nor with HOMA-IR in women. In addition, maternal BMI was positively associated with a higher offspring lean body mass in men. Conclusions High maternal BMI was associated with lower 2-hour plasma glucose concentration, especially in non-obese men. Offspring lean body mass may be a mediating factor for the association. ...
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Additional information about fundingHBCS was supported by Emil Aaltonen Foundation, Finnish Foundation for Cardiovascular Research, Finnish Foundation for Diabetes Research, Finnish Foundation for Pediatric Research, Juho Vainio Foundation, Novo Nordisk Foundation, Signe and Ane Gyllenberg Foundation, Samfundet Folkhälsan, Finska Läkaresällskapet, Liv och Hälsa, European Commission FP7 (DORIAN) grant agreement no 278603 and EU H2020-PHC-2014-DynaHealth grant no. 633595. The Academy of Finland supported MBvB (grant no. 257239), EK (grant no. 127437, 129306, 130326, 134791 and 2639249) JGE (grant no. 129369, 129907, 135072, 129255 and 126775). ...
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