Antibiotics accelerate growth at the expense of immunity
Galarza, J. A., Murphy, L., & Mappes, J. (2021). Antibiotics accelerate growth at the expense of immunity. Proceedings of the Royal Society B : Biological Sciences, 288(1961), Article 20211819. https://doi.org/10.1098/rspb.2021.1819
Julkaistu sarjassa
Proceedings of the Royal Society B : Biological SciencesPäivämäärä
2021Oppiaine
Evoluutiotutkimus (huippuyksikkö)Ekologia ja evoluutiobiologiaCentre of Excellence in Evolutionary ResearchEcology and Evolutionary BiologyTekijänoikeudet
© 2021 The Authors. Published by the Royal Society.
Antibiotics have long been used in the raising of animals for agricultural, industrial or laboratory use. The use of subtherapeutic doses in diets of terrestrial and aquatic animals to promote growth is common and highly debated. Despite their vast application in animal husbandry, knowledge about the mechanisms behind growth promotion is minimal, particularly at the molecular level. Evidence from evolutionary research shows that immunocompetence is resource-limited, and hence expected to trade off with other resource-demanding processes, such as growth. Here, we ask if accelerated growth caused by antibiotics can be explained by genome-wide trade-offs between growth and costly immunocompetence. We explored this idea by injecting broad-spectrum antibiotics into wood tiger moth (Arctia plantaginis) larvae during development. We follow several life-history traits and analyse gene expression (RNA-seq) and bacterial (r16S) profiles. Moths treated with antibiotics show a substantial depletion of bacterial taxa, faster growth rate, a significant downregulation of genes involved in immunity and significant upregulation of growth-related genes. These results suggest that the presence of antibiotics may aid in up-keeping the immune system. Hence, by reducing the resource load of this costly process, bodily resources may be reallocated to other key processes such as growth.
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Julkaisija
The Royal SocietyISSN Hae Julkaisufoorumista
0962-8452Asiasanat
Julkaisuun liittyvä(t) tutkimusaineisto(t)
https://rs.figshare.com/collections/Supplementary_material_from_Antibiotics_accelerate_growth_at_the_expense_of_immunity_/5658453Julkaisu tutkimustietojärjestelmässä
https://converis.jyu.fi/converis/portal/detail/Publication/101583638
Metadata
Näytä kaikki kuvailutiedotKokoelmat
Rahoittaja(t)
Suomen AkatemiaRahoitusohjelmat(t)
Akatemiahanke, SA; Akatemiaprofessorin tutkimuskulut, SALisätietoja rahoituksesta
This project was funded by the Academy of Finland grant nos. 322536 to J.A.G. and 320438 to J.M.Lisenssi
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