Näytä suppeat kuvailutiedot

dc.contributor.authorGalarza, Juan A.
dc.contributor.authorMurphy, Liam
dc.contributor.authorMappes, Johanna
dc.date.accessioned2021-10-26T09:13:01Z
dc.date.available2021-10-26T09:13:01Z
dc.date.issued2021
dc.identifier.citationGalarza, J. A., Murphy, L., & Mappes, J. (2021). Antibiotics accelerate growth at the expense of immunity. <i>Proceedings of the Royal Society B : Biological Sciences</i>, <i>288</i>(1961), Article 20211819. <a href="https://doi.org/10.1098/rspb.2021.1819" target="_blank">https://doi.org/10.1098/rspb.2021.1819</a>
dc.identifier.otherCONVID_101583638
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/78345
dc.description.abstractAntibiotics have long been used in the raising of animals for agricultural, industrial or laboratory use. The use of subtherapeutic doses in diets of terrestrial and aquatic animals to promote growth is common and highly debated. Despite their vast application in animal husbandry, knowledge about the mechanisms behind growth promotion is minimal, particularly at the molecular level. Evidence from evolutionary research shows that immunocompetence is resource-limited, and hence expected to trade off with other resource-demanding processes, such as growth. Here, we ask if accelerated growth caused by antibiotics can be explained by genome-wide trade-offs between growth and costly immunocompetence. We explored this idea by injecting broad-spectrum antibiotics into wood tiger moth (Arctia plantaginis) larvae during development. We follow several life-history traits and analyse gene expression (RNA-seq) and bacterial (r16S) profiles. Moths treated with antibiotics show a substantial depletion of bacterial taxa, faster growth rate, a significant downregulation of genes involved in immunity and significant upregulation of growth-related genes. These results suggest that the presence of antibiotics may aid in up-keeping the immune system. Hence, by reducing the resource load of this costly process, bodily resources may be reallocated to other key processes such as growth.en
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherThe Royal Society
dc.relation.ispartofseriesProceedings of the Royal Society B : Biological Sciences
dc.rightsCC BY 4.0
dc.subject.otherimmunity trade-off
dc.subject.othermicrobiome
dc.subject.othergrowth promotion
dc.subject.otherantibiotics
dc.titleAntibiotics accelerate growth at the expense of immunity
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-202110265375
dc.contributor.laitosBio- ja ympäristötieteiden laitosfi
dc.contributor.laitosDepartment of Biological and Environmental Scienceen
dc.contributor.oppiaineEvoluutiotutkimus (huippuyksikkö)fi
dc.contributor.oppiaineEkologia ja evoluutiobiologiafi
dc.contributor.oppiaineCentre of Excellence in Evolutionary Researchen
dc.contributor.oppiaineEcology and Evolutionary Biologyen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1
dc.description.reviewstatuspeerReviewed
dc.relation.issn0962-8452
dc.relation.numberinseries1961
dc.relation.volume288
dc.type.versionpublishedVersion
dc.rights.copyright© 2021 The Authors. Published by the Royal Society.
dc.rights.accesslevelopenAccessfi
dc.relation.grantnumber322536
dc.relation.grantnumber320438
dc.subject.ysogeeniekspressio
dc.subject.ysogeenit
dc.subject.ysoeläimet
dc.subject.ysokotieläintuotanto
dc.subject.ysoRNA-interferenssi
dc.subject.ysomikrobisto
dc.subject.ysoimmuunijärjestelmä
dc.subject.ysoimmunologia
dc.subject.ysokarjanhoito
dc.subject.ysoantibiootit
dc.subject.ysojalostus
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p25831
jyx.subject.urihttp://www.yso.fi/onto/yso/p147
jyx.subject.urihttp://www.yso.fi/onto/yso/p2023
jyx.subject.urihttp://www.yso.fi/onto/yso/p1423
jyx.subject.urihttp://www.yso.fi/onto/yso/p38816
jyx.subject.urihttp://www.yso.fi/onto/yso/p27039
jyx.subject.urihttp://www.yso.fi/onto/yso/p16041
jyx.subject.urihttp://www.yso.fi/onto/yso/p18810
jyx.subject.urihttp://www.yso.fi/onto/yso/p6049
jyx.subject.urihttp://www.yso.fi/onto/yso/p10820
jyx.subject.urihttp://www.yso.fi/onto/yso/p5084
dc.rights.urlhttps://creativecommons.org/licenses/by/4.0/
dc.relation.datasethttps://rs.figshare.com/collections/Supplementary_material_from_Antibiotics_accelerate_growth_at_the_expense_of_immunity_/5658453
dc.relation.doi10.1098/rspb.2021.1819
dc.relation.funderResearch Council of Finlanden
dc.relation.funderResearch Council of Finlanden
dc.relation.funderSuomen Akatemiafi
dc.relation.funderSuomen Akatemiafi
jyx.fundingprogramAcademy Project, AoFen
jyx.fundingprogramResearch costs of Academy Professor, AoFen
jyx.fundingprogramAkatemiahanke, SAfi
jyx.fundingprogramAkatemiaprofessorin tutkimuskulut, SAfi
jyx.fundinginformationThis project was funded by the Academy of Finland grant nos. 322536 to J.A.G. and 320438 to J.M.
dc.type.okmA1


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