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• Small things matter : of phages and antibiotic resistance conferring plasmids 

  Mattila, Sari (University of Jyväskylä, 2016)

  Viruses and plasmids are small units of genetic material dependent on cells either transiently or continuously. Intriguingly, stories of these small entities intertwine in antibiotic resistance crisis. Horizontal gene ...

• Beta-Lactam Sensitive Bacteria Can Acquire ESBL-Resistance via Conjugation after Long-Term Exposure to Lethal Antibiotic Concentration 

  Ruotsalainen, Pilvi; Given, Cindy; Penttinen, Reetta; Jalasvuori, Matti (MDPI, 2020)

  Beta-lactams are commonly used antibiotics that prevent cell-wall biosynthesis. Beta-lactam sensitive bacteria can acquire conjugative resistance elements and hence become resistant even after being exposed to lethal (above ...

• Fight evolution with evolution: plasmid-dependent phages with a wide host range prevent the spread of antibiotic resistances 

  Ojala, Ville; Laitalainen, Jarkko; Jalasvuori, Matti (Wiley-Blackwell, 2013)

  The emergence of pathogenic bacteria resistant to multiple antibiotics is a serious worldwide public health concern. Whenever antibiotics are applied, the genes encoding for antibiotic resistance are selected for within ...

• Preceding Host History of Conjugative Resistance Plasmids Affects Intra- and Interspecific Transfer Potential from Biofilm 

  Jonsdottir, Ilmur; Given, Cindy; Penttinen, Reetta; Jalasvuori, Matti (American Society for Microbiology, 2023)

  Conjugative plasmids can confer antimicrobial resistance (AMR) to their host bacterium. The plasmids disperse even between distantly related host species, rescuing the host from otherwise detrimental effects of antibiotics. ...

• Indirect Selection against Antibiotic Resistance via Specialized Plasmid-Dependent Bacteriophages 

  Penttinen, Reetta; Given, Cindy; Jalasvuori, Matti (MDPI AG, 2021)

  Antibiotic resistance genes of important Gram-negative bacterial pathogens are residing in mobile genetic elements such as conjugative plasmids. These elements rapidly disperse between cells when antibiotics are present ...