Counteracting the horizontal spread of bacterial antibiotic resistance with conjugative plasmid-dependent bacteriophages
DisciplineSolu- ja molekyylibiologia
PublisherUniversity of Jyväskylä
MetadataShow full item record
- Väitöskirjat 
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Mattila, Sari (University of Jyväskylä, 2016)Viruses and plasmids are small units of genetic material dependent on cells either transiently or continuously. Intriguingly, stories of these small entities intertwine in antibiotic resistance crisis. Horizontal gene ...
Beta-Lactam Sensitive Bacteria Can Acquire ESBL-Resistance via Conjugation after Long-Term Exposure to Lethal Antibiotic Concentration Ruotsalainen, Pilvi; Given, Cindy; Penttinen, Reetta; Jalasvuori, Matti (MDPI, 2020)Beta-lactams are commonly used antibiotics that prevent cell-wall biosynthesis. Beta-lactam sensitive bacteria can acquire conjugative resistance elements and hence become resistant even after being exposed to lethal (above ...
Fight evolution with evolution: plasmid-dependent phages with a wide host range prevent the spread of antibiotic resistances Ojala, Ville; Laitalainen, Jarkko; Jalasvuori, Matti (Wiley-Blackwell, 2013)The emergence of pathogenic bacteria resistant to multiple antibiotics is a serious worldwide public health concern. Whenever antibiotics are applied, the genes encoding for antibiotic resistance are selected for within ...
Penttinen, Reetta; Given, Cindy; Jalasvuori, Matti (MDPI AG, 2021)Antibiotic resistance genes of important Gram-negative bacterial pathogens are residing in mobile genetic elements such as conjugative plasmids. These elements rapidly disperse between cells when antibiotics are present ...
Conjugative ESBL plasmids differ in their potential to rescue susceptible bacteria via horizontal gene transfer in lethal antibiotic concentrations Mattila, Sari; Ruotsalainen, Pilvi; Ojala, Ville; Tuononen, Timo; Hiltunen, Teppo; Jalasvuori, Matti (Nature Publishing Group; Japan Antibiotics Research Association, 2017)