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dc.contributor.authorMullen, Jenny
dc.contributor.authorBækken, Lasse Vestli
dc.contributor.authorTörmäkangas, Timo
dc.contributor.authorEkström, Lena
dc.contributor.authorEricsson, Magnus
dc.contributor.authorHullstein, Ingunn R.
dc.contributor.authorJ Schulze, Jenny
dc.date.accessioned2020-02-19T14:05:00Z
dc.date.available2020-02-19T14:05:00Z
dc.date.issued2020
dc.identifier.citationMullen, J., Bækken, L. V., Törmäkangas, T., Ekström, L., Ericsson, M., Hullstein, I. R., & J Schulze, J. (2020). Inter‐individual variation of the urinary steroid profiles in Swedish and Norwegian athletes. <i>Drug Testing and Analysis</i>, <i>12</i>(6), 720-730. <a href="https://doi.org/10.1002/dta.2778" target="_blank">https://doi.org/10.1002/dta.2778</a>
dc.identifier.otherCONVID_34611412
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/67902
dc.description.abstractThe steroidal module of the Athlete Biological Passport (ABP) aims to detect doping with endogenous steroids, e.g. testosterone (T), by longitudinally monitoring several biomarkers. These biomarkers are ratios combined of urinary concentrations of testosterone and metabolically related steroids. However, it is evident after five years of monitoring steroid passports, that there are large variations in the steroid ratios complicating its interpretation. In this study, we used over 11 000 urinary steroid profiles from Swedish and Norwegian athletes to determine both the inter‐ and intra‐individual variations of all steroids and ratios in the steroidal passport. Furthermore, we investigated if the inter‐individual variations could be associated with factors such as gender, type of sport, age, time of day, time of year and if the urine was collected in or out of competition. We show that there are factors reported in today's doping tests that significantly affect the steroid profiles. The factors with the largest influence on the steroid profile was what type of sport classification the athlete belonged to as well as if the urine was collected in or out of competition. There were also significant differences based on what time of day and time of year the urine sample was collected. If these significant changes are relevant when longitudinally monitoring athletes in the steroidal module of the ABP, has to be further evaluated.en
dc.format.mimetypeapplication/pdf
dc.languageeng
dc.language.isoeng
dc.publisherJohn Wiley & Sons
dc.relation.ispartofseriesDrug Testing and Analysis
dc.rightsCC BY 4.0
dc.subject.otherbiologinen passi
dc.subject.otherdoping in sports
dc.subject.otherathlete biological passport
dc.subject.othersteroid profile
dc.subject.otherconfounding factors
dc.subject.otherurinary steroids
dc.titleInter‐individual variation of the urinary steroid profiles in Swedish and Norwegian athletes
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-202002192130
dc.contributor.laitosLiikuntatieteellinen tiedekuntafi
dc.contributor.laitosFaculty of Sport and Health Sciencesen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.description.reviewstatuspeerReviewed
dc.format.pagerange720-730
dc.relation.issn1942-7603
dc.relation.numberinseries6
dc.relation.volume12
dc.type.versionacceptedVersion
dc.rights.copyright© 2020 The Authors. Drug Testing and Analysis published by John Wiley & Sons Ltd
dc.rights.accesslevelopenAccessfi
dc.subject.ysourheilijat
dc.subject.ysovaihtelu
dc.subject.ysotestausmenetelmät
dc.subject.ysoprofiilit (tieto)
dc.subject.ysovirtsa
dc.subject.ysodoping
dc.subject.ysosteroidit
dc.subject.ysobiomarkkerit
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p3315
jyx.subject.urihttp://www.yso.fi/onto/yso/p8653
jyx.subject.urihttp://www.yso.fi/onto/yso/p26360
jyx.subject.urihttp://www.yso.fi/onto/yso/p30204
jyx.subject.urihttp://www.yso.fi/onto/yso/p15222
jyx.subject.urihttp://www.yso.fi/onto/yso/p5674
jyx.subject.urihttp://www.yso.fi/onto/yso/p10983
jyx.subject.urihttp://www.yso.fi/onto/yso/p12288
dc.rights.urlhttps://creativecommons.org/licenses/by/4.0/
dc.relation.doi10.1002/dta.2778
jyx.fundinginformationThis work was supported by grants from the World-Anti Doping Agency.


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