Inter‐individual variation of the urinary steroid profiles in Swedish and Norwegian athletes
Mullen, J., Bækken, L. V., Törmäkangas, T., Ekström, L., Ericsson, M., Hullstein, I. R., & J Schulze, J. (2020). Inter‐individual variation of the urinary steroid profiles in Swedish and Norwegian athletes. Drug Testing and Analysis, 12(6), 720-730. https://doi.org/10.1002/dta.2778
Published inDrug Testing and Analysis
© 2020 The Authors. Drug Testing and Analysis published by John Wiley & Sons Ltd
The steroidal module of the Athlete Biological Passport (ABP) aims to detect doping with endogenous steroids, e.g. testosterone (T), by longitudinally monitoring several biomarkers. These biomarkers are ratios combined of urinary concentrations of testosterone and metabolically related steroids. However, it is evident after five years of monitoring steroid passports, that there are large variations in the steroid ratios complicating its interpretation. In this study, we used over 11 000 urinary steroid profiles from Swedish and Norwegian athletes to determine both the inter‐ and intra‐individual variations of all steroids and ratios in the steroidal passport. Furthermore, we investigated if the inter‐individual variations could be associated with factors such as gender, type of sport, age, time of day, time of year and if the urine was collected in or out of competition. We show that there are factors reported in today's doping tests that significantly affect the steroid profiles. The factors with the largest influence on the steroid profile was what type of sport classification the athlete belonged to as well as if the urine was collected in or out of competition. There were also significant differences based on what time of day and time of year the urine sample was collected. If these significant changes are relevant when longitudinally monitoring athletes in the steroidal module of the ABP, has to be further evaluated. ...
PublisherJohn Wiley & Sons
Publication in research information system
MetadataShow full item record
- Liikuntatieteiden tiedekunta 
Additional information about fundingThis work was supported by grants from the World-Anti Doping Agency.
Showing items with similar title or keywords.
Basal Endogenous Steroid Hormones, Sex Hormone-Binding Globulin, Physical Fitness, and Health Risk Factors in Young Adult Men Gagnon, Sheila S.; Nindl, Bradley C.; Vaara, Jani; Santtila, Matti; Häkkinen, Keijo; Kyröläinen, Heikki (Frontiers Research Foundation, 2018)Purpose: Few large-scale population-based studies have adequately examined the relationships between steroid hormones, health status and physical fitness. The purpose of the study was to describe the relationship of serum ...
Relationship between inflammatory biomarkers and testosterone levels in male master athletes and non-athletes Pinheiro Barbosa, Luca; da Silva Aguiar, Samuel; Anderson Santos, Patrick; Rosa dos Santos, Thiago; Alves Maciel, Larissa; Alves de Deus, Lysleine; Vanerson Passos Neves, Rodrigo; Lopes de Araújo Leite, Patrício; Duarte Gutierrez, Sara; Victor Sousa, Caio; Korhonen, Marko T.; Degens, Hans; Gustavo Simões, Herbert (Elsevier, 2021)Background Aging is often associated with low-grade systemic inflammation and reduced anabolic hormone levels. To investigate whether lifelong exercise training can decrease the age-related low-grade inflammation and ...
Plasma lipid profile associates with the improvement of psychological well-being in individuals with perceived stress symptoms Noerman, Stefania; Klåvus, Anton; Järvelä-Reijonen, Elina; Karhunen, Leila; Auriola, Seppo; Korpela, Riitta; Lappalainen, Raimo; Kujala, Urho M.; Puttonen, Sampsa; Kolehmainen, Marjukka; Hanhineva, Kati (Nature Publishing Group, 2020)Psychological stress is a suggested risk factor of metabolic disorders, but molecular mediators are not well understood. We investigated the association between the metabolic profiles of fasting plasma and the improvement ...
Substantial fat mass loss reduces low-grade inflammation and induces positive alteration in cardiometabolic factors in normal-weight individuals Sarin, H. V.; Lee, J. H.; Jauhiainen, M.; Joensuu, A.; Borodulin, K.; Männistö, S.; Jin, Z.; Terwilliger, J. D.; Isola, Ville; Ahtiainen, Juha; Häkkinen, Keijo; Kristiansson, K.; Hulmi, Juha; Perola, M. (Nature Publishing Group, 2019)The accumulation of fat, especially in visceral sites, is a significant risk factor for several chronic diseases with altered cardiometabolic homeostasis. We studied how intensive long-term weight loss and subsequent weight ...
Moazami-Goodarzi, Ali; Sorkkila, Matilda; Aunola, Kaisa; Ryba, Tatiana V. (Human Kinetics Publishers, 2020)The present study examined the identity profiles that upper-secondary-school Finnish student-athletes show, and the extent to which these profiles were associated with their athletic and academic achievements and withdrawal ...