1H NMR Urinary Metabolomic Analysis in Older Adults after Hip Fracture Surgery May Provide Valuable Information for Patient Profiling : A Preliminary Investigation
Douzi, W., Bon, D., Suikkanen, S., Soukkio, P., Boildieu, N., Nenonen, A., Hupli, M., Kukkonen-Harjula, K., & Dugué, B. (2022). 1H NMR Urinary Metabolomic Analysis in Older Adults after Hip Fracture Surgery May Provide Valuable Information for Patient Profiling : A Preliminary Investigation. Metabolites, 12(8), Article 744. https://doi.org/10.3390/metabo12080744
© 2022 by the authors. Licensee MDPI, Basel, Switzerland
In these times of precision and personalized medicine, profiling patients to identify their needs is crucial to providing the best and most cost-effective treatment. In this study, we used urine metabolomics to explore the characterization of older adults with hip fractures and to explore the forecasting of patient outcomes. Overnight urine specimens were collected from 33 patients (mean age 80 ± 8 years) after hip fracture surgery during their stay at a rehabilitation hospital. The specimens were analyzed with 1H NMR spectroscopy. We performed a metabolomics study regarding assessments of frailty status, Functional Independence Measure (FIM), and Short Physical Performance Battery (SPPB). The main metabolic variations concerned 10 identified metabolites: paracetamol derivatives (4 peaks: 2.15 ppm; 2.16 ppm; 7.13 ppm and 7.15 ppm); hippuric acid; acetate; acetone; dimethylamine; glycine; alanine; lactate; valine; TMAO. At baseline, the urinary levels of these metabolites were significantly higher (i) in frail compared with non-frail patients, (ii) in persons with poorer FIM scores, and (iii) in persons with poorer compared SPPB scores. Our findings suggested that patients with increased levels of urine metabolites associated with metabolic, inflammatory, and renal disorders presented clear signs of frailty, impaired functional independence, and poor physical performance. Metabolomics could be a valuable tool to further characterize older adults, especially after major medical events. ...
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Additional information about fundingThe authors acknowledge South Karelia Social and Health Care District (Eksote), Finland (grant number 1236/00.01.05.01/2013); The Social Insurance Institution of Finland (Kela) (grant numbers 94/331/2013 and 17/26/2019), the State Research Funding for Academic Health Research (Ministry of Social Affairs and Health, through Helsinki University Hospital (HUS)), Finland (grant numbers HUS 2016 (no grant number assigned), HUS/2931/2017, HUS/2571/2017, HUS/2631/2019, 864/2020), the “Institut National de la Santé et de la Recherche Médicale” (INSERM), the European Union (ERDF) and “Région Nouvelle Aquitaine” for ﬁnancial supports. ...
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