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dc.contributor.authorRamakrishnan, Saminathan
dc.contributor.authorIjäs, Heini
dc.contributor.authorLinko, Veikko
dc.contributor.authorKeller, Adrian
dc.date.accessioned2018-10-08T06:05:32Z
dc.date.available2018-10-08T06:05:32Z
dc.date.issued2018
dc.identifier.citationRamakrishnan, S., Ijäs, H., Linko, V., & Keller, A. (2018). Structural stability of DNA origami nanostructures under application-specific conditions. <i>Computational and Structural Biotechnology Journal</i>, <i>16</i>, 342-349. <a href="https://doi.org/10.1016/j.csbj.2018.09.002" target="_blank">https://doi.org/10.1016/j.csbj.2018.09.002</a>
dc.identifier.otherCONVID_28268472
dc.identifier.otherTUTKAID_78869
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/59774
dc.description.abstractWith the introduction of the DNA origami technique, it became possible to rapidly synthesize almost arbitrarily shaped molecular nanostructures at nearly stoichiometric yields. The technique furthermore provides absolute addressability in the sub-nm range, rendering DNA origami nanostructures highly attractive substrates for the controlled arrangement of functional species such as proteins, dyes, and nanoparticles. Consequently, DNAorigami nanostructures have found applications in numerous areas of fundamental and applied research, ranging from drug delivery to biosensing to plasmonics to inorganic materials synthesis. Since many of those applications rely on structurally intact, well-definedDNA origami shapes, the issue of DNA origami stability under numerous application-relevant environmental conditions has received increasing interest in the past few years. In this mini-review we discuss the structural stability, denaturation, and degradation of DNA origami nanostructures under different conditions relevant to the fields of biophysics and biochemistry, biomedicine, and materials science, and the methods to improve their stability for desired applications.fi
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherResearch Network of Computational and Structural Biotechnology
dc.relation.ispartofseriesComputational and Structural Biotechnology Journal
dc.rightsCC BY 4.0
dc.subject.otherDNA origami
dc.subject.otherstability
dc.subject.otherdenaturation
dc.subject.otherdrug delivery
dc.titleStructural stability of DNA origami nanostructures under application-specific conditions
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201810014271
dc.contributor.laitosBio- ja ympäristötieteiden laitosfi
dc.contributor.laitosDepartment of Biological and Environmental Scienceen
dc.contributor.oppiaineSolu- ja molekyylibiologiafi
dc.contributor.oppiaineCell and Molecular Biologyen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2018-10-01T09:15:18Z
dc.description.reviewstatuspeerReviewed
dc.format.pagerange342-349
dc.relation.issn2001-0370
dc.relation.numberinseries0
dc.relation.volume16
dc.type.versionpublishedVersion
dc.rights.copyright© 2018 The Authors. Published by Elsevier B.V. on behalf of Research Network of Computational and Structural Biotechnology
dc.rights.accesslevelopenAccessfi
dc.subject.ysonanorakenteet
dc.subject.ysoDNA
dc.subject.ysobiofysiikka
dc.subject.ysomateriaalitiede
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p25315
jyx.subject.urihttp://www.yso.fi/onto/yso/p7690
jyx.subject.urihttp://www.yso.fi/onto/yso/p6097
jyx.subject.urihttp://www.yso.fi/onto/yso/p14779
dc.rights.urlhttps://creativecommons.org/licenses/by/4.0/
dc.relation.doi10.1016/j.csbj.2018.09.002


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