DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications
Piskunen, P., Shen, B., Julin, S., Ijäs, H., Toppari, J. J., Kostiainen, M. A., & Linko, V. (2019). DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications. Journal of Visualized Experiments, 2019(151), Article e60313. https://doi.org/10.3791/60313
Published inJournal of Visualized Experiments
© Authors, 2019
Structural DNA nanotechnology provides a viable route for building from the bottom-up using DNA as construction material. The most common DNA nanofabrication technique is called DNA origami, and it allows high-throughput synthesis of accurate and highly versatile structures with nanometer-level precision. Here, it is shown how the spatial information of DNA origami can be transferred to metallic nanostructures by combining the bottom-up DNA origami with the conventionally used top-down lithography approaches. This allows fabrication of billions of tiny nanostructures in one step onto selected substrates. The method is demonstrated using bowtie DNA origami to create metallic bowtie-shaped antenna structures on silicon nitride or sapphire substrates. The method relies on the selective growth of a silicon oxide layer on top of the origami deposition substrate, thus resulting in a patterning mask for following lithographic steps. These nanostructure-equipped surfaces can be further used as molecular sensors (e.g., surface-enhanced Raman spectroscopy (SERS)) and in various other optical applications at the visible wavelength range owing to the small feature sizes (sub-10 nm). The technique can be extended to other materials through methodological modifications; therefore, the resulting optically active surfaces may find use in development of metamaterials and metasurfaces. ...
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Additional information about fundingThis work was supported by the Academy of Finland (projects 286845, 308578, 303804, 267497), the Jane and Aatos Erkko Foundation, and the Sigrid Jusélius Foundation. This work was carried out under the Academy of Finland Centers of Excellence Programme (2014–2019).
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