Structural stability of DNA origami nanostructures under application-specific conditions
Ramakrishnan, S., Ijäs, H., Linko, V., & Keller, A. (2018). Structural stability of DNA origami nanostructures under application-specific conditions. Computational and Structural Biotechnology Journal, 16, 342-349. https://doi.org/10.1016/j.csbj.2018.09.002
Published inComputational and Structural Biotechnology Journal
© 2018 The Authors. Published by Elsevier B.V. on behalf of Research Network of Computational and Structural Biotechnology
With the introduction of the DNA origami technique, it became possible to rapidly synthesize almost arbitrarily shaped molecular nanostructures at nearly stoichiometric yields. The technique furthermore provides absolute addressability in the sub-nm range, rendering DNA origami nanostructures highly attractive substrates for the controlled arrangement of functional species such as proteins, dyes, and nanoparticles. Consequently, DNAorigami nanostructures have found applications in numerous areas of fundamental and applied research, ranging from drug delivery to biosensing to plasmonics to inorganic materials synthesis. Since many of those applications rely on structurally intact, well-definedDNA origami shapes, the issue of DNA origami stability under numerous application-relevant environmental conditions has received increasing interest in the past few years. In this mini-review we discuss the structural stability, denaturation, and degradation of DNA origami nanostructures under different conditions relevant to the fields of biophysics and biochemistry, biomedicine, and materials science, and the methods to improve their stability for desired applications. ...
PublisherResearch Network of Computational and Structural Biotechnology
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