Early life stress and frailty in old age : the Helsinki birth cohort study
M. J. Haapanen, M. M. Perälä, M. K. Salonen, E. Kajantie, M. Simonen, P. Pohjolainen, A. K. Pesonen, K. Räikkönen, J. G. Eriksson, von Bonsdorff, Mikaela. (2018). Early life stress and frailty in old age : the Helsinki birth cohort study. BMC Geriatrics, 18, Article 179. https://doi.org/10.1186/s12877-018-0873-5
Julkaistu sarjassa
BMC GeriatricsTekijät
Päivämäärä
2018Oppiaine
Gerontologia ja kansanterveysGerontologian tutkimuskeskusHyvinvoinnin tutkimuksen yhteisöGerontology and Public HealthGerontology Research CenterSchool of WellbeingTekijänoikeudet
© 2018 the Author(s)
Background
Evidence suggests that early life stress (ELS) may extend its effect into adulthood and predispose an individual to adverse health outcomes. We investigated whether wartime parental separation, an indicator of severe ELS, would be associated with frailty in old age.
Methods
Of the 972 participants belonging to the present sub-study of the Helsinki Birth Cohort Study, 117 (12.0%) had been evacuated abroad unaccompanied by their parents in childhood during World War II. Frailty was assessed at a mean age of 71 years according to Fried’s criteria.
Results
Thirteen frail men (4 separated and 9 non-separated) and 20 frail women (2 separated and 18 non-separated) were identified. Compared to the non-separated men, men who had been separated had an increased relative risk ratio (RRR) of frailty (age-adjusted RRR 3.93, 95% CI 1.02, 15.11) that persisted after adjusting for several confounders. No associations were observed among women (RRR 0.62; 95% CI 0.13, 2.94).
Conclusions
These preliminary results suggest that ELS might extend its effects not just into adulthood but also into old age, and secondly, that men may be more vulnerable to the long-term effects of ELS.
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Julkaisija
BioMed CentralISSN Hae Julkaisufoorumista
1471-2318Asiasanat
Julkaisu tutkimustietojärjestelmässä
https://converis.jyu.fi/converis/portal/detail/Publication/28208573
Metadata
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Infant and childhood growth and frailty in old age : the Helsinki Birth Cohort Study
Haapanen, M. J.; Perälä, M. M.; Osmond, C.; Salonen, M. K.; Kajantie, E.; Rantanen, Taina; Simonen, M.; Pohjolainen, P.; Eriksson, J. G.; von Bonsdorff, Mikaela (Springer, 2019)Background Evidence from life course studies highlights the importance of infant and childhood growth as risk factors for adulthood chronic diseases. Methods In this sub-study of the Helsinki Birth Cohort Study, we ... -
Work careers in adults separated temporarily from their parents in childhood during World War II
Salonen, Minna K.; von Bonsdorff, Mikaela; Kautiainen, Hannu; von Bonsdorff, Monika; Kajantie, Eero; Wasenius, Niko S.; Pesonen, Anukatriina; Räikkönen, Katri; Eriksson, Johan G. (Elsevier Inc., 2019)Introduction: Traumatic experiences, such as separation from parents in childhood causing early life stress (ELS) may increase the risk of adverse long-term health outcomes and biological age-related changes. This may ... -
Early life determinants of frailty in old age : the Helsinki Birth Cohort Stud
Haapanen, M. J.; Perälä, M. M.; Salonen, M. K.; Kajantie, E.; Simonen, M.; Pohjolainen, P.; Eriksson, J. G.; von Bonsdorff, Mikaela (Oxford University Press, 2018)Background there is evidence suggesting that several chronic diseases have their origins in utero and that development taking place during sensitive periods may affect the aging process. We investigated whether early life ... -
Telomere Length and Frailty : The Helsinki Birth Cohort Study
Haapanen, Markus J.; Perälä, Mia-Maria; Salonen, Minna K.; Guzzardi, Maria A.; Iozzo, Patricia; Kajantie, Eero; Rantanen, Taina; Simonen, Mika; Pohjolainen, Pertti; Eriksson, Johan G.; von Bonsdorff, Mikaela (Elsevier Inc., 2018)Objectives: Telomere length is associated with aging-related pathologies. Although the association between telomere length and frailty has been studied previously, only a few studies assessing longitudinal changes in ... -
Association between resilience and frailty in older age : Findings from the Helsinki Birth Cohort Study
Stenroth, Sini M.; Pynnönen, Katja; Haapanen, Markus J.; Vuoskoski, Pirjo; Mikkola, Tuija M.; Eriksson, Johan G.; von Bonsdorff, Mikaela B. (Elsevier BV, 2023)Objectives Resilience, a capacity to cope with adversity, has been linked to better functioning and health in older age. However, little is still known about resilience in relation to frailty. We explored whether resilience ...
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