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dc.contributor.authorHaapanen, M. J.
dc.contributor.authorPerälä, M. M.
dc.contributor.authorSalonen, M. K.
dc.contributor.authorKajantie, E.
dc.contributor.authorSimonen, M.
dc.contributor.authorPohjolainen, P.
dc.contributor.authorPesonen, A. K.
dc.contributor.authorRäikkönen, K.
dc.contributor.authorEriksson, J. G.
dc.contributor.authorvon Bonsdorff, Mikaela
dc.date.accessioned2018-08-14T12:29:37Z
dc.date.available2018-08-14T12:29:37Z
dc.date.issued2018fi
dc.identifier.citationM. J. Haapanen, M. M. Perälä, M. K. Salonen, E. Kajantie, M. Simonen, P. Pohjolainen, . . . von Bonsdorff, M. (2018). Early life stress and frailty in old age : the Helsinki birth cohort study. <em>BMC Geriatrics</em>, 18, 179. <a href="https://doi.org/10.1186/s12877-018-0873-5">doi:10.1186/s12877-018-0873-5</a>fi
dc.identifier.otherTUTKAID_78512
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/59211
dc.description.abstractBackground Evidence suggests that early life stress (ELS) may extend its effect into adulthood and predispose an individual to adverse health outcomes. We investigated whether wartime parental separation, an indicator of severe ELS, would be associated with frailty in old age. Methods Of the 972 participants belonging to the present sub-study of the Helsinki Birth Cohort Study, 117 (12.0%) had been evacuated abroad unaccompanied by their parents in childhood during World War II. Frailty was assessed at a mean age of 71 years according to Fried’s criteria. Results Thirteen frail men (4 separated and 9 non-separated) and 20 frail women (2 separated and 18 non-separated) were identified. Compared to the non-separated men, men who had been separated had an increased relative risk ratio (RRR) of frailty (age-adjusted RRR 3.93, 95% CI 1.02, 15.11) that persisted after adjusting for several confounders. No associations were observed among women (RRR 0.62; 95% CI 0.13, 2.94). Conclusions These preliminary results suggest that ELS might extend its effects not just into adulthood but also into old age, and secondly, that men may be more vulnerable to the long-term effects of ELS.fi
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherBioMed Central
dc.relation.ispartofseriesBMC Geriatrics
dc.rightsCC BY 4.0
dc.subject.otherlapsuusfi
dc.subject.otherstressifi
dc.subject.otherterveysvaikutuksetfi
dc.subject.otherriskitekijätfi
dc.subject.othersotalapsetfi
dc.subject.otherearly life stressfi
dc.subject.otherfrailtyfi
dc.subject.otherlife-coursefi
dc.subject.othernatural experimentfi
dc.subject.otherrisk factorsfi
dc.titleEarly life stress and frailty in old age : the Helsinki birth cohort studyfi
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201808143833
dc.contributor.laitosLiikuntatieteellinen tiedekuntafi
dc.contributor.laitosFaculty of Sport and Health Sciencesen
dc.contributor.oppiaineGerontologia ja kansanterveys
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2018-08-14T12:15:03Z
dc.description.reviewstatuspeerReviewed
dc.relation.issn1471-2318
dc.relation.numberinseries0
dc.relation.volume18
dc.type.versionpublishedVersion
dc.rights.copyright© 2018 the Author(s)
dc.rights.accesslevelopenAccessfi
dc.format.contentfulltext
dc.rights.urlhttps://creativecommons.org/licenses/by/4.0/
dc.relation.doi10.1186/s12877-018-0873-5


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