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dc.contributor.authorM. J. Haapanen
dc.contributor.authorM. M. Perälä
dc.contributor.authorM. K. Salonen
dc.contributor.authorE. Kajantie
dc.contributor.authorM. Simonen
dc.contributor.authorP. Pohjolainen
dc.contributor.authorA. K. Pesonen
dc.contributor.authorK. Räikkönen
dc.contributor.authorJ. G. Eriksson
dc.contributor.authorvon Bonsdorff, Mikaela
dc.date.accessioned2018-08-14T12:29:37Z
dc.date.available2018-08-14T12:29:37Z
dc.date.issued2018
dc.identifier.citationM. J. Haapanen, M. M. Perälä, M. K. Salonen, E. Kajantie, M. Simonen, P. Pohjolainen, A. K. Pesonen, K. Räikkönen, J. G. Eriksson, von Bonsdorff, Mikaela. (2018). Early life stress and frailty in old age : the Helsinki birth cohort study. <i>BMC Geriatrics</i>, <i>18</i>, Article 179. <a href="https://doi.org/10.1186/s12877-018-0873-5" target="_blank">https://doi.org/10.1186/s12877-018-0873-5</a>
dc.identifier.otherCONVID_28208573
dc.identifier.otherTUTKAID_78512
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/59211
dc.description.abstractBackground Evidence suggests that early life stress (ELS) may extend its effect into adulthood and predispose an individual to adverse health outcomes. We investigated whether wartime parental separation, an indicator of severe ELS, would be associated with frailty in old age. Methods Of the 972 participants belonging to the present sub-study of the Helsinki Birth Cohort Study, 117 (12.0%) had been evacuated abroad unaccompanied by their parents in childhood during World War II. Frailty was assessed at a mean age of 71 years according to Fried’s criteria. Results Thirteen frail men (4 separated and 9 non-separated) and 20 frail women (2 separated and 18 non-separated) were identified. Compared to the non-separated men, men who had been separated had an increased relative risk ratio (RRR) of frailty (age-adjusted RRR 3.93, 95% CI 1.02, 15.11) that persisted after adjusting for several confounders. No associations were observed among women (RRR 0.62; 95% CI 0.13, 2.94). Conclusions These preliminary results suggest that ELS might extend its effects not just into adulthood but also into old age, and secondly, that men may be more vulnerable to the long-term effects of ELS.fi
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherBioMed Central
dc.relation.ispartofseriesBMC Geriatrics
dc.rightsCC BY 4.0
dc.subject.otherearly life stress
dc.subject.otherfrailty
dc.subject.otherlife-course
dc.subject.othernatural experiment
dc.titleEarly life stress and frailty in old age : the Helsinki birth cohort study
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201808143833
dc.contributor.laitosLiikuntatieteellinen tiedekuntafi
dc.contributor.laitosFaculty of Sport and Health Sciencesen
dc.contributor.oppiaineGerontologia ja kansanterveysfi
dc.contributor.oppiaineGerontologian tutkimuskeskusfi
dc.contributor.oppiaineGerontology and Public Healthen
dc.contributor.oppiaineGerontology Research Centeren
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2018-08-14T12:15:03Z
dc.description.reviewstatuspeerReviewed
dc.relation.issn1471-2318
dc.relation.numberinseries0
dc.relation.volume18
dc.type.versionpublishedVersion
dc.rights.copyright© 2018 the Author(s)
dc.rights.accesslevelopenAccessfi
dc.subject.ysolapsuus
dc.subject.ysostressi
dc.subject.ysoterveysvaikutukset
dc.subject.ysoriskitekijät
dc.subject.ysosotalapset
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p13735
jyx.subject.urihttp://www.yso.fi/onto/yso/p133
jyx.subject.urihttp://www.yso.fi/onto/yso/p15449
jyx.subject.urihttp://www.yso.fi/onto/yso/p13277
jyx.subject.urihttp://www.yso.fi/onto/yso/p6910
dc.rights.urlhttps://creativecommons.org/licenses/by/4.0/
dc.relation.doi10.1186/s12877-018-0873-5


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