Early life determinants of frailty in old age : the Helsinki Birth Cohort Stud
Haapanen, M. J., Perälä, M.M., Salonen, M. K., Kajantie, E., Simonen, M., Pohjolainen, P., Eriksson, J. G., & von Bonsdorff, M. (2018). Early life determinants of frailty in old age : the Helsinki Birth Cohort Stud. Age and Ageing, 47(4), 569-575. https://doi.org/10.1093/ageing/afy052
Published inAge and Ageing
© The Authors 2018.
Background there is evidence suggesting that several chronic diseases have their origins in utero and that development taking place during sensitive periods may affect the aging process. We investigated whether early life determinants would be associated with frailty in old age. Methods at a mean age of 71 years, 1,078 participants belonging to the Helsinki Birth Cohort Study were assessed for frailty according to the Fried frailty criteria. Early life measurements (birth weight, length, mother body mass index [BMI] and parity) were obtained from birth, child welfare and school health records. Multinomial regression analysis was used to assess the association between early life determinants and frailty in old age. Results weight, length and BMI at birth were all inversely associated with frailty in old age. A 1 kg increase in birth weight was associated with a lower relative risk ratio (RRR) of frailty (age and sex-adjusted RRR = 0.40, 95% CI: 0.19, 0.82) compared to non-frailty. Associations persisted after adjusting for several confounding factors. Compared to cohort members in the upper middle class, those who as adults worked as manual workers or belonged to the lower middle class, were at an increased risk of frailty. Conclusions those who were small at birth were at an increased risk of developing frailty in old age, suggesting that frailty is at least partly programmed in early life. A less privileged socioeconomic status in adulthood was associated with an increased risk of frailty in old age. ...
PublisherOxford University Press
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Haapanen, M. J.; Perälä, M. M.; Osmond, C.; Salonen, M. K.; Kajantie, E.; Rantanen, Taina; Simonen, M.; Pohjolainen, P.; Eriksson, J. G.; von Bonsdorff, Mikaela (Springer, 2019)Background Evidence from life course studies highlights the importance of infant and childhood growth as risk factors for adulthood chronic diseases. Methods In this sub-study of the Helsinki Birth Cohort Study, we ...
Haapanen, Markus J.; Perälä, Mia-Maria; Salonen, Minna K.; Guzzardi, Maria A.; Iozzo, Patricia; Kajantie, Eero; Rantanen, Taina; Simonen, Mika; Pohjolainen, Pertti; Eriksson, Johan G.; von Bonsdorff, Mikaela (Elsevier Inc., 2018)Objectives: Telomere length is associated with aging-related pathologies. Although the association between telomere length and frailty has been studied previously, only a few studies assessing longitudinal changes in ...
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Birth Size and Childhood Growth as Determinants of Physical Functioning in Older Age: the Helsinki Birth Cohort Study von Bonsdorff, Mikaela; Rantanen, Taina; Sipilä, Sarianna; Salonen, Minna K.; Kajantie, Eero; Osmond, Clive; Barker, David J.P.; Eriksson, Johan G. (Oxford University Press, 2011)The study reports on the associations of infant and childhood anthropometric measurements, early growth, and the combined effect of birth weight and childhood body mass index with older age physical functioning among 1,999 ...