Infant and childhood growth and frailty in old age : the Helsinki Birth Cohort Study
Haapanen, M. J., Perälä, M.M., Osmond, C., Salonen, M. K., Kajantie, E., Rantanen, T., Simonen, M., Pohjolainen, P., Eriksson, J. G., & von Bonsdorff, M. (2019). Infant and childhood growth and frailty in old age : the Helsinki Birth Cohort Study. Aging Clinical and Experimental Research, 31(5), 717-721. https://doi.org/10.1007/s40520-018-1011-0
Published inAging Clinical and Experimental Research
© Springer Nature Switzerland AG 2018
Background Evidence from life course studies highlights the importance of infant and childhood growth as risk factors for adulthood chronic diseases. Methods In this sub-study of the Helsinki Birth Cohort Study, we studied 1078 individuals who had both information on body size from birth to 12 years of age and who were assessed for frailty according to the Fried criteria at the mean age of 71 years. Results Greater BMI gain between 2 and 11 years in boys was associated with frailty in old age (age-adjusted RRR 2.36, 95% CI 1.21, 4.63). No similar associations were observed in girls. Conclusions Men who were frail in old age experienced accelerated BMI gain in childhood compared with those men who were not frail. This was not observed in women, which suggests that the patterns of early growth predisposing to frailty may vary by sex.
Publication in research information system
MetadataShow full item record
- Liikuntatieteiden tiedekunta 
Showing items with similar title or keywords.
Early-Life Factors as Predictors of Age-Associated Deficit Accumulation Across 17 Years From Midlife Into Old Age Haapanen, Markus J.; Jylhävä, Juulia; Kortelainen, Lauri; Mikkola, Tuija M.; Salonen, Minna; Wasenius, Niko S.; Kajantie, Eero; Eriksson, Johan G.; von Bonsdorff, Mikaela B. (Oxford University Press (OUP), 2022)Background Early life exposures have been associated with the risk of frailty in old age. We investigated whether early life exposures predict the level and rate of change in a frailty index (FI) from midlife into old ...
Haapanen, M. J.; Perälä, M. M.; Salonen, M. K.; Kajantie, E.; Simonen, M.; Pohjolainen, P.; Eriksson, J. G.; von Bonsdorff, Mikaela (Oxford University Press, 2018)Background there is evidence suggesting that several chronic diseases have their origins in utero and that development taking place during sensitive periods may affect the aging process. We investigated whether early life ...
Haapanen, Markus J.; Perälä, Mia-Maria; Salonen, Minna K.; Guzzardi, Maria A.; Iozzo, Patricia; Kajantie, Eero; Rantanen, Taina; Simonen, Mika; Pohjolainen, Pertti; Eriksson, Johan G.; von Bonsdorff, Mikaela (Elsevier Inc., 2018)Objectives: Telomere length is associated with aging-related pathologies. Although the association between telomere length and frailty has been studied previously, only a few studies assessing longitudinal changes in ...
The utilization of primary healthcare services among frail older adults : findings from the Helsinki Birth Cohort Study Ikonen, Jenni N.; Eriksson, Johan G.; von Bonsdorff, Mikaela B.; Kajantie, Eero; Arponen, Otso; Haapanen, Markus J. (Biomed Central, 2022)Background The impact of frailty on primary healthcare service use, especially general practice office visits and remote contacts, is currently unknown. Further, little is known about the association of frailty with ...
Older persons with signs of frailty in a home-based physical exercise intervention : baseline characteristics of an RCT Suikkanen, Sara; Soukkio, Paula; Pitkälä, Kaisu; Kääriä, Sanna; Kautiainen, Hannu; Sipilä, Sarianna; Kukkonen-Harjula, Katriina; Hupli, Markku (Springer International Publishing, 2019)Background Increasing the level of physical activity among persons with signs of frailty improves physical functioning. There is a lack of long-term supervised physical exercise intervention studies including a validated ...