Infant and childhood growth and frailty in old age : the Helsinki Birth Cohort Study
Haapanen, M. J., Perälä, M.M., Osmond, C., Salonen, M. K., Kajantie, E., Rantanen, T., Simonen, M., Pohjolainen, P., Eriksson, J. G., & von Bonsdorff, M. (2019). Infant and childhood growth and frailty in old age : the Helsinki Birth Cohort Study. Aging Clinical and Experimental Research, 31(5), 717-721. https://doi.org/10.1007/s40520-018-1011-0
Published inAging Clinical and Experimental Research
DisciplineGerontologia ja kansanterveysGerontologian tutkimuskeskusGerontology and Public HealthGerontology Research Center
© Springer Nature Switzerland AG 2018
Background Evidence from life course studies highlights the importance of infant and childhood growth as risk factors for adulthood chronic diseases. Methods In this sub-study of the Helsinki Birth Cohort Study, we studied 1078 individuals who had both information on body size from birth to 12 years of age and who were assessed for frailty according to the Fried criteria at the mean age of 71 years. Results Greater BMI gain between 2 and 11 years in boys was associated with frailty in old age (age-adjusted RRR 2.36, 95% CI 1.21, 4.63). No similar associations were observed in girls. Conclusions Men who were frail in old age experienced accelerated BMI gain in childhood compared with those men who were not frail. This was not observed in women, which suggests that the patterns of early growth predisposing to frailty may vary by sex.
ISSN Search the Publication Forum1594-0667
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Body composition in late midlife as a predictor of accelerated age-associated deficit accumulation from late midlife into old age : a longitudinal birth cohort study Haapanen, Markus J.; Mikkola, Tuija M.; Kortelainen, Lauri; Jylhävä, Juulia; Wasenius, Niko S.; Kajantie, Eero; Eriksson, Johan G.; von Bonsdorff, Mikaela B. (Oxford University Press (OUP), 2022)Background Body mass index (BMI) may not be an optimal predictor of frailty as its constituents, lean and fat mass, may have opposite associations with frailty. Methods A linear mixed model analysis was performed in ...
Early life stress and frailty in old age : the Helsinki birth cohort study M. J. Haapanen; M. M. Perälä; M. K. Salonen; E. Kajantie; M. Simonen; P. Pohjolainen; A. K. Pesonen; K. Räikkönen; J. G. Eriksson; von Bonsdorff, Mikaela (BioMed Central, 2018)Background Evidence suggests that early life stress (ELS) may extend its effect into adulthood and predispose an individual to adverse health outcomes. We investigated whether wartime parental separation, an indicator ...
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Telomere Length and Frailty : The Helsinki Birth Cohort Study Haapanen, Markus J.; Perälä, Mia-Maria; Salonen, Minna K.; Guzzardi, Maria A.; Iozzo, Patricia; Kajantie, Eero; Rantanen, Taina; Simonen, Mika; Pohjolainen, Pertti; Eriksson, Johan G.; von Bonsdorff, Mikaela (Elsevier Inc., 2018)Objectives: Telomere length is associated with aging-related pathologies. Although the association between telomere length and frailty has been studied previously, only a few studies assessing longitudinal changes in ...
Early life determinants of frailty in old age : the Helsinki Birth Cohort Stud Haapanen, M. J.; Perälä, M. M.; Salonen, M. K.; Kajantie, E.; Simonen, M.; Pohjolainen, P.; Eriksson, J. G.; von Bonsdorff, Mikaela (Oxford University Press, 2018)Background there is evidence suggesting that several chronic diseases have their origins in utero and that development taking place during sensitive periods may affect the aging process. We investigated whether early life ...