Infant and childhood growth and frailty in old age : the Helsinki Birth Cohort Study
Haapanen, M. J., Perälä, M.M., Osmond, C., Salonen, M. K., Kajantie, E., Rantanen, T., Simonen, M., Pohjolainen, P., Eriksson, J. G., & von Bonsdorff, M. (2019). Infant and childhood growth and frailty in old age : the Helsinki Birth Cohort Study. Aging Clinical and Experimental Research, 31(5), 717-721. https://doi.org/10.1007/s40520-018-1011-0
Published in
Aging Clinical and Experimental ResearchDate
2019Discipline
Gerontologia ja kansanterveysGerontologian tutkimuskeskusGerontology and Public HealthGerontology Research CenterCopyright
© Springer Nature Switzerland AG 2018
Background
Evidence from life course studies highlights the importance of infant and childhood growth as risk factors for adulthood chronic diseases.
Methods
In this sub-study of the Helsinki Birth Cohort Study, we studied 1078 individuals who had both information on body size from birth to 12 years of age and who were assessed for frailty according to the Fried criteria at the mean age of 71 years.
Results
Greater BMI gain between 2 and 11 years in boys was associated with frailty in old age (age-adjusted RRR 2.36, 95% CI 1.21, 4.63). No similar associations were observed in girls.
Conclusions
Men who were frail in old age experienced accelerated BMI gain in childhood compared with those men who were not frail. This was not observed in women, which suggests that the patterns of early growth predisposing to frailty may vary by sex.
Publisher
SpringerISSN Search the Publication Forum
1594-0667Keywords
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Except where otherwise noted, this item's license is described as In Copyright