Telomere Length and Frailty : The Helsinki Birth Cohort Study
Haapanen, M. J., Perälä, M.-M., Salonen, M. K., Guzzardi, M. A., Iozzo, P., Kajantie, E., Rantanen, T., Simonen, M., Pohjolainen, P., Eriksson, J. G., & von Bonsdorff, M. (2018). Telomere Length and Frailty : The Helsinki Birth Cohort Study. Journal of the American Medical Directors Association, 19(8), 658-662. https://doi.org/10.1016/j.jamda.2018.05.011
© 2018 AMDA - The Society for Post-Acute and Long-Term Care Medicine.
Objectives: Telomere length is associated with aging-related pathologies. Although the association between telomere length and frailty has been studied previously, only a few studies assessing longitudinal changes in telomere length and frailty exist. Design: Longitudinal cohort study. Setting and participants: A subpopulation of the Helsinki Birth Cohort Study consisting of 1078 older adults aged 67 to 79 years born in Helsinki, Finland, between 1934 and 1944. Measures: Relative leukocyte telomere length (LTL) was measured using quantitative real-time polymerase chain reaction at the average ages of 61 and 71 years, and at the latter the participants were assessed for frailty according to Fried criteria. Results: The mean SD relative LTLs were 1.40 0.29 (average age 61 years) and 0.86 0.30 (average age 71 years) for the cohort. A trend of shorter mean relative LTL across frailty groups was observed at 61 years (P ¼ .016) and at 71 years (P ¼ .057). Relative LTL at age 61 years was significantly associated with frailty: per 1-unit increase in relative LTL, the corresponding relative risk ratio (RRR) of frailty was 0.28 (95% confidence interval [CI] 0.08e0.97), adjusting for several confounders. Also, LTL at age 71 years was associated with frailty (RRR 0.18, 95% CI 0.04e0.81) after adjustment for sex, age, and adult socioeconomic status, but further adjustment attenuated the association. No associations between telomere shortening and frailty were observed during the 10-year follow-up. Conclusions: Shorter relative LTL was associated with frailty in cross-sectional and longitudinal analyses, but telomere shortening was not, suggesting that short LTL may be a biomarker of frailty. ...
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Haapanen, M. J.; Perälä, M. M.; Salonen, M. K.; Kajantie, E.; Simonen, M.; Pohjolainen, P.; Eriksson, J. G.; von Bonsdorff, Mikaela (Oxford University Press, 2018)Background there is evidence suggesting that several chronic diseases have their origins in utero and that development taking place during sensitive periods may affect the aging process. We investigated whether early life ...
Haapanen, M. J.; Perälä, M. M.; Osmond, C.; Salonen, M. K.; Kajantie, E.; Rantanen, Taina; Simonen, M.; Pohjolainen, P.; Eriksson, J. G.; von Bonsdorff, Mikaela (Springer, 2019)Background Evidence from life course studies highlights the importance of infant and childhood growth as risk factors for adulthood chronic diseases. Methods In this sub-study of the Helsinki Birth Cohort Study, we ...
Åström, Max J.; von Bonsdorff, Mikaela B.; Perälä, Mia-Maria; Salonen, Minna K.; Rantanen, Taina; Kajantie, Eero; Simonen, Mika; Pohjolainen, Pertti; Haapanen, Markus J.; Guzzardi, Maria A.; Iozzo, Patricia; Kautiainen, Hannu; Eriksson, Johan G. (Elsevier, 2019)Telomere length has been suggested a biomarker of aging and is associated with several chronic diseases. However, the association between telomere length and physical performance is not well known. Using both cross-sectional ...
Retirement age and type as predictors of frailty : a retrospective cohort study of older businessmen Haapanen, Markus J.; von Bonsdorff, Mikaela B.; Perttilä, Niko M.; Törmäkangas, Timo; von Bonsdorff, Monika E.; Strandberg, Arto Y.; Strandberg, Timo E. (BMJ Publishing Group Ltd, 2020)Objectives: To study the association between retirement characteristics and frailty in a homogenous population of former business executives. Design: Cross-sectional cohort study using data from the Helsinki Businessmen ...
Older persons with signs of frailty in a home-based physical exercise intervention : baseline characteristics of an RCT Suikkanen, Sara; Soukkio, Paula; Pitkälä, Kaisu; Kääriä, Sanna; Kautiainen, Hannu; Sipilä, Sarianna; Kukkonen-Harjula, Katriina; Hupli, Markku (Springer International Publishing, 2019)Background Increasing the level of physical activity among persons with signs of frailty improves physical functioning. There is a lack of long-term supervised physical exercise intervention studies including a validated ...