Early life stress and frailty in old age : the Helsinki birth cohort study
M. J. Haapanen, M. M. Perälä, M. K. Salonen, E. Kajantie, M. Simonen, P. Pohjolainen, A. K. Pesonen, K. Räikkönen, J. G. Eriksson, von Bonsdorff, Mikaela. (2018). Early life stress and frailty in old age : the Helsinki birth cohort study. BMC Geriatrics, 18, Article 179. https://doi.org/10.1186/s12877-018-0873-5
Published inBMC Geriatrics
DisciplineGerontologia ja kansanterveysGerontologian tutkimuskeskusHyvinvoinnin tutkimuksen yhteisöGerontology and Public HealthGerontology Research CenterSchool of Wellbeing
© 2018 the Author(s)
Background Evidence suggests that early life stress (ELS) may extend its effect into adulthood and predispose an individual to adverse health outcomes. We investigated whether wartime parental separation, an indicator of severe ELS, would be associated with frailty in old age. Methods Of the 972 participants belonging to the present sub-study of the Helsinki Birth Cohort Study, 117 (12.0%) had been evacuated abroad unaccompanied by their parents in childhood during World War II. Frailty was assessed at a mean age of 71 years according to Fried’s criteria. Results Thirteen frail men (4 separated and 9 non-separated) and 20 frail women (2 separated and 18 non-separated) were identified. Compared to the non-separated men, men who had been separated had an increased relative risk ratio (RRR) of frailty (age-adjusted RRR 3.93, 95% CI 1.02, 15.11) that persisted after adjusting for several confounders. No associations were observed among women (RRR 0.62; 95% CI 0.13, 2.94). Conclusions These preliminary results suggest that ELS might extend its effects not just into adulthood but also into old age, and secondly, that men may be more vulnerable to the long-term effects of ELS. ...
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Haapanen, M. J.; Perälä, M. M.; Osmond, C.; Salonen, M. K.; Kajantie, E.; Rantanen, Taina; Simonen, M.; Pohjolainen, P.; Eriksson, J. G.; von Bonsdorff, Mikaela (Springer, 2019)Background Evidence from life course studies highlights the importance of infant and childhood growth as risk factors for adulthood chronic diseases. Methods In this sub-study of the Helsinki Birth Cohort Study, we ...
Body Composition in Late Midlife as a Predictor of Accelerated Age-associated Deficit-accumulation From Late Midlife into Old Age : A Longitudinal Birth Cohort Study Haapanen, Markus J.; Mikkola, Tuija M.; Kortelainen, Lauri; Jylhävä, Juulia; Wasenius, Niko S.; Kajantie, Eero; Eriksson, Johan G.; von Bonsdorff, Mikaela B. (Oxford University Press (OUP), 2023)Background Body mass index (BMI) may not be an optimal predictor of frailty as its constituents, lean and fat mass, may have opposite associations with frailty. Methods A linear mixed model analysis was performed in ...
Salonen, Minna K.; von Bonsdorff, Mikaela; Kautiainen, Hannu; von Bonsdorff, Monika; Kajantie, Eero; Wasenius, Niko S.; Pesonen, Anukatriina; Räikkönen, Katri; Eriksson, Johan G. (Elsevier Inc., 2019)Introduction: Traumatic experiences, such as separation from parents in childhood causing early life stress (ELS) may increase the risk of adverse long-term health outcomes and biological age-related changes. This may ...
Haapanen, M. J.; Perälä, M. M.; Salonen, M. K.; Kajantie, E.; Simonen, M.; Pohjolainen, P.; Eriksson, J. G.; von Bonsdorff, Mikaela (Oxford University Press, 2018)Background there is evidence suggesting that several chronic diseases have their origins in utero and that development taking place during sensitive periods may affect the aging process. We investigated whether early life ...
Haapanen, Markus J.; Perälä, Mia-Maria; Salonen, Minna K.; Guzzardi, Maria A.; Iozzo, Patricia; Kajantie, Eero; Rantanen, Taina; Simonen, Mika; Pohjolainen, Pertti; Eriksson, Johan G.; von Bonsdorff, Mikaela (Elsevier Inc., 2018)Objectives: Telomere length is associated with aging-related pathologies. Although the association between telomere length and frailty has been studied previously, only a few studies assessing longitudinal changes in ...