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dc.contributor.authorLaakkonen, Eija
dc.contributor.authorRonkainen, Paula
dc.contributor.authorSuominen, Harri
dc.contributor.authorTakala, Timo
dc.contributor.authorKoskinen, Satu
dc.contributor.authorPuolakka, Jukka
dc.contributor.authorSipilä, Sarianna
dc.contributor.authorKovanen, Vuokko
dc.date.accessioned2017-05-11T07:13:17Z
dc.date.available2017-05-11T07:13:17Z
dc.date.issued2007
dc.identifier.citationLaakkonen, E., Ronkainen, P., Suominen, H., Takala, T., Koskinen, S., Puolakka, J., Sipilä, S., & Kovanen, V. (2007). Muscular Transcriptome in Postmenopausal Women With or Without Hormone Replacement. <i>Rejuvenation Research</i>, <i>10</i>(4), 485-500. <a href="https://doi.org/10.1089/rej.2007.0536" target="_blank">https://doi.org/10.1089/rej.2007.0536</a>
dc.identifier.otherCONVID_17216667
dc.identifier.otherTUTKAID_27396
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/53885
dc.description.abstractThe loss of muscle mass and strength with aging is well characterized, but our knowledge of the molecular mechanisms underlying the development of sarcopenia remains incomplete. Although menopause is often accompanied with first signs of age-associated changes in muscle structure and function, the effects of hormone replacement therapy (HRT) or menopause-related decline in estrogen production in the muscles of postmenopausal women is not well understood. Furthermore the knowledge of the global transcriptional changes that take place in skeletal muscle in relation to estrogen status has thus far been completely lacking. We used a randomized double-blinded study design together with an explorative microarray experiment to characterize possible effects of continuous, combined HRT and estrogen deprivation on the skeletal muscle of fifteen women. Here, we report the differential response of both Gene Ontology-annotated biological processes and some individual genes responding differentially to the use or non-use of HRT. Our results revealed transcription level changes in, for example, muscle protein and energy metabolism. In particular, the ubiquitine-proteosome system was found to be effected at several levels. HRT seemed to partially counteract the postmenopause-related transcriptional changes. Our results suggest that during the early postmenopausal years, when there is no counteracting medication available, muscle transcriptome changes notably, whereas HRT appears to slow down this phenomenon and could therefore aid in maintaining proper muscle mass and function after menopause.
dc.language.isoeng
dc.publisherRejuvenation Research
dc.relation.ispartofseriesRejuvenation Research
dc.subject.othermenopaussi
dc.subject.otherhormonikorvaushoito
dc.subject.othersarkopenia
dc.subject.otherlihastranskriptomi
dc.subject.otherhormone replacement therapy
dc.subject.othersarcopenia
dc.subject.othermuscular transcriptome
dc.titleMuscular Transcriptome in Postmenopausal Women With or Without Hormone Replacement
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201705082229
dc.contributor.laitosTerveystieteiden laitosfi
dc.contributor.laitosDepartment of Health Sciencesen
dc.contributor.oppiaineGerontologia ja kansanterveysfi
dc.contributor.oppiaineGerontologian tutkimuskeskusfi
dc.contributor.oppiaineHyvinvoinnin tutkimuksen yhteisöfi
dc.contributor.oppiaineGerontology and Public Healthen
dc.contributor.oppiaineGerontology Research Centeren
dc.contributor.oppiaineSchool of Wellbeingen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2017-05-08T12:15:11Z
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1
dc.description.reviewstatuspeerReviewed
dc.format.pagerange485-500
dc.relation.issn1549-1684
dc.relation.numberinseries4
dc.relation.volume10
dc.type.versionacceptedVersion
dc.rights.copyright© 2007 Mary Ann Liebert, Inc. This is a final draft version of an article whose final and definitive form has been published by Mary Ann Liebert. Published in this repository with the kind permission of the publisher.
dc.rights.accesslevelopenAccessfi
dc.subject.ysovaihdevuodet
jyx.subject.urihttp://www.yso.fi/onto/yso/p17397
dc.relation.doi10.1089/rej.2007.0536
dc.type.okmA1


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