Global gene expression profiles in skeletal muscle of monozygotic female twins discordant for hormone replacement therapy.
Ronkainen, P., Laakkonen, E., Alén, M., Pitkänen, R., Puolakka, J., Kujala, U., Kaprio, J., Sipilä, S., & Kovanen, V. (2010). Global gene expression profiles in skeletal muscle of monozygotic female twins discordant for hormone replacement therapy.. Aging Cell, 9(6), 1098-1110. https://doi.org/10.1111/j.1474-9726.2010.00636.x
Julkaistu sarjassa
Aging CellTekijät
Päivämäärä
2010Oppiaine
Gerontologia ja kansanterveysLiikuntalääketiedeGerontologian tutkimuskeskusHyvinvoinnin tutkimuksen yhteisöGerontology and Public HealthSports and Exercise MedicineGerontology Research CenterSchool of WellbeingTekijänoikeudet
© 2010 The Authors Aging Cell © 2010 Blackwell Publishing Ltd/Anatomical Society of Great Britain and Ireland. This is an open access article distributed under the terms of a Creative Commons License.
Aging is accompanied by inexorable loss of muscle tissue. One of the underlying causes for this is the massive change in the hormonal milieu of the body. The role of a female sex steroid – estrogen – in these processes is frequently neglected, although the rapid decline in its production coincides with a steep deterioration in muscle performance. We recruited 54- to 62-year-old monozygotic female twin pairs discordant for postmenopausal hormone replacement therapy (HRT, n = 11 pairs; HRT use 7.3 ± 3.7 years) from the Finnish Twin Cohort to investigate the association of long-term, estrogen-based HRT with skeletal muscle transcriptome. Pathway analysis of muscle transcript profiles revealed significant HRT-induced up-regulation of a biological process related to regulation of cell structure and down-regulation of processes concerning, for example, cell–matrix interactions, energy metabolism and utilization of nutrients (false discovery rate < 0.15). Lending clinical relevance to the findings, these processes explained a significant fraction of the differences observed in relative proportion of muscle within thigh and in muscle performance (R2 = 0.180–0.257, P = 0.001–0.023). Although energy metabolism was affected through down-regulation of the transcripts related to succinate dehydrogenase complex in mitochondria, no differences were observed in mtDNA copy number or oxidative capacity per muscle cross section. In conclusion, long-term use of HRT was associated with subtle, but significant, differences in muscle transcript profiles. The better muscle composition and performance among the HRT users appeared to be orchestrated by improved regulatory actions on cytoskeleton, preservation of muscle quality via regulation of intramuscular extracellular matrix and a switch from glucose-oriented metabolism to utilization of fatty acids.
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Julkaisija
Blackwell Publishing Ltd/Anatomical Society of Great Britain and IrelandISSN Hae Julkaisufoorumista
1474-9718Asiasanat
Julkaisu tutkimustietojärjestelmässä
https://converis.jyu.fi/converis/portal/detail/Publication/19927126
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Influence of long-term postmenopausal hormone replacement therapy on estimated structural bone strength: A study in discordant monozygotic twins.
Mikkola, Tuija; Heinonen, Ari; Kovanen, Vuokko; Cheng, Sulin; Kujala, Urho; Suominen, Harri; Alén, Markku; Puolakka, Jukka; Ankarberg-Lindgren, Carina; Ronkainen, Paula; Koskenvuo, Markku; Kaprio, Jaakko; Rantanen, Taina; Sipilä, Sarianna (Wiley Blackwell, 2011)Although postmenopausal hormone-replacement therapy (HRT) is known to prevent fractures, knowledge on the influence of long-term HRT on bone strength and its determinants other than areal bone mineral density is scarce. ... -
Hormone replacement therapy enhances IGF-1 signaling in skeletal muscle by diminishing miR-182 and miR-233 expressions: A study on postmenopausal monozygotic twin pairs
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Pöllänen, Eija (University of Jyväskylä, 2011) -
Muscular Transcriptome in Postmenopausal Women With or Without Hormone Replacement
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Postmenopausal Hormone Replacement Therapy Modifies Skeletal Muscle Composition and Function: A Study with Monozygotic Twin Pairs
Ronkainen, Paula; Kovanen, Vuokko; Alén, Markku; Laakkonen, Eija; Palonen, Eeva-Maija; Ankarberg-Lindgren, Carina; Hämäläinen, Esa; Turpeinen, Ursula; Kujala, Urho; Puolakka, Jukka; Kaprio, Jaakko; Sipilä, Sarianna (American Physiological Society, 2009)We investigated whether long-term hormone replacement therapy (HRT) is associated with mobility and lower limb muscle performance and composition in postmenopausal women. Fifteen 54- to 62-yr-old monozygotic female twin ...
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