Power training and postmenopausal hormone therapy affect transcriptional control of specific co-regulated gene clusters in skeletal muscle
Pöllänen, E., Fey, V., Törmäkangas, T., Ronkainen, P., Taaffe, D., Takala, T., Koskinen, S., Cheng, S., Puolakka, J., Kujala, U., Suominen, H., Sipilä, S., & Kovanen, V. (2010). Power training and postmenopausal hormone therapy affect transcriptional control of specific co-regulated gene clusters in skeletal muscle. AGE, 32(3), 347-363. https://doi.org/10.1007/s11357-010-9140-1
DisciplineGerontologia ja kansanterveysLiikuntalääketiedeGerontologian tutkimuskeskusGerontology and Public HealthSports and Exercise MedicineGerontology Research Center
© The Author(s) 2010. This article is published with open access at Springerlink.com.
At the moment, there is no clear molecular explanation for the steeper decline in muscle performance after menopause or the mechanisms of counteractive treatments. The goal of this genome-wide study was to identify the genes and gene clusters through which power training (PT) comprising jumping activities or estrogen containing hormone replacement therapy (HRT) may affect skeletal muscle properties after menopause. We used musculus vastus lateralis samples from early stage postmenopausal (50–57 years old) women participating in a yearlong randomized double-blind placebo-controlled trial with PT and HRT interventions. Using microarray platform with over 24,000 probes, we identified 665 differentially expressed genes. The hierarchical clustering method was used to assort the genes. Additionally, enrichment analysis of gene ontology (GO) terms and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways was carried out to clarify whether assorted gene clusters are enriched with particular functional categories. The analysis revealed transcriptional regulation of 49 GO/KEGG categories. PT upregulated transcription in “response to contraction”—category revealing novel candidate genes for contraction-related regulation of muscle function while HRT upregulated gene expression related to functionality of mitochondria. Moreover, several functional categories tightly related to muscle energy metabolism, development, and function were affected regardless of the treatment. Our results emphasize that during the early stages of the postmenopause, muscle properties are under transcriptional modulation, which both PT and HRT partially counteract leading to preservation of muscle power and potentially reducing the risk for aging-related muscle weakness. More specifically, PT and HRT may function through improving energy metabolism, response to contraction as well as by preserving functionality of the mitochondria. ...
ISSN Search the Publication Forum2452-0756
Publication in research information system
MetadataShow full item record
- Liikuntatieteiden tiedekunta 
Showing items with similar title or keywords.
Muscular Transcriptome in Postmenopausal Women With or Without Hormone Replacement Laakkonen, Eija; Ronkainen, Paula; Suominen, Harri; Takala, Timo; Koskinen, Satu; Puolakka, Jukka; Sipilä, Sarianna; Kovanen, Vuokko (Rejuvenation Research, 2007)The loss of muscle mass and strength with aging is well characterized, but our knowledge of the molecular mechanisms underlying the development of sarcopenia remains incomplete. Although menopause is often accompanied with ...
Regulation of gene expression and steroidogenesis in skeletal muscle of postmenopausal women : with emphasis on the effects of hormone replacement and power training Pöllänen, Eija (University of Jyväskylä, 2011)
Global gene expression profiles in skeletal muscle of monozygotic female twins discordant for hormone replacement therapy. Ronkainen, Paula; Laakkonen, Eija; Alén, Markku; Pitkänen, Reino; Puolakka, Jukka; Kujala, Urho; Kaprio, Jaakko; Sipilä, Sarianna; Kovanen, Vuokko (Blackwell Publishing Ltd/Anatomical Society of Great Britain and Ireland, 2010)Aging is accompanied by inexorable loss of muscle tissue. One of the underlying causes for this is the massive change in the hormonal milieu of the body. The role of a female sex steroid – estrogen – in these processes is ...
Estrogenic regulation of skeletal muscle proteome : a study of premenopausal women and postmenopausal MZ cotwins discordant for hormonal therapy Laakkonen, Eija; Soliymani, Rabah; Karvinen, Sira; Kaprio, Jaakko; Kujala, Urho; Baumann, Marc; Sipilä, Sarianna; Kovanen, Vuokko; Lalowski, Maciej (Wiley-Blackwell Publishing Ltd, 2017)Female middle age is characterized by a decline in skeletal muscle mass and performance, predisposing women to sarcopenia, functional limitations, and metabolic dysfunction as they age. Menopausal loss of ovarian function ...
Influence of long-term postmenopausal hormone replacement therapy on estimated structural bone strength: A study in discordant monozygotic twins. Mikkola, Tuija; Heinonen, Ari; Kovanen, Vuokko; Cheng, Sulin; Kujala, Urho; Suominen, Harri; Alén, Markku; Puolakka, Jukka; Ankarberg-Lindgren, Carina; Ronkainen, Paula; Koskenvuo, Markku; Kaprio, Jaakko; Rantanen, Taina; Sipilä, Sarianna (Wiley Blackwell, 2011)Although postmenopausal hormone-replacement therapy (HRT) is known to prevent fractures, knowledge on the influence of long-term HRT on bone strength and its determinants other than areal bone mineral density is scarce. ...