Muscular Transcriptome in Postmenopausal Women With or Without Hormone Replacement
Laakkonen, E., Ronkainen, P., Suominen, H., Takala, T., Koskinen, S., Puolakka, J., Sipilä, S., & Kovanen, V. (2007). Muscular Transcriptome in Postmenopausal Women With or Without Hormone Replacement. Rejuvenation Research, 10(4), 485-500. https://doi.org/10.1089/rej.2007.0536
Julkaistu sarjassa
Rejuvenation ResearchTekijät
Päivämäärä
2007Oppiaine
Gerontologia ja kansanterveysGerontologian tutkimuskeskusHyvinvoinnin tutkimuksen yhteisöGerontology and Public HealthGerontology Research CenterSchool of WellbeingTekijänoikeudet
© 2007 Mary Ann Liebert, Inc. This is a final draft version of an article whose final and definitive form has been published by Mary Ann Liebert. Published in this repository with the kind permission of the publisher.
The loss of muscle mass and strength with aging is well characterized, but our knowledge of the molecular mechanisms underlying the development of sarcopenia remains incomplete. Although menopause is often accompanied with first signs of age-associated changes in muscle structure and function, the effects of hormone replacement therapy (HRT) or menopause-related decline in estrogen production in the muscles of postmenopausal women is not well understood. Furthermore the knowledge of the global transcriptional changes that take place in skeletal muscle in relation to estrogen status has thus far been completely lacking. We used a randomized double-blinded study design together with an explorative microarray experiment to characterize possible effects of continuous, combined HRT and estrogen deprivation on the skeletal muscle of fifteen women. Here, we report the differential response of both Gene Ontology-annotated biological processes and some individual genes responding differentially to the use or non-use of HRT. Our results revealed transcription level changes in, for example, muscle protein and energy metabolism. In particular, the ubiquitine-proteosome system was found to be effected at several levels. HRT seemed to partially counteract the postmenopause-related transcriptional changes. Our results suggest that during the early postmenopausal years, when there is no counteracting medication available, muscle transcriptome changes notably, whereas HRT appears to slow down this phenomenon and could therefore aid in maintaining proper muscle mass and function after menopause.
...
Julkaisija
Rejuvenation ResearchISSN Hae Julkaisufoorumista
1549-1684Asiasanat
Julkaisu tutkimustietojärjestelmässä
https://converis.jyu.fi/converis/portal/detail/Publication/17216667
Metadata
Näytä kaikki kuvailutiedotKokoelmat
- Liikuntatieteiden tiedekunta [3139]
Samankaltainen aineisto
Näytetään aineistoja, joilla on samankaltainen nimeke tai asiasanat.
-
Influence of long-term postmenopausal hormone replacement therapy on estimated structural bone strength: A study in discordant monozygotic twins.
Mikkola, Tuija; Heinonen, Ari; Kovanen, Vuokko; Cheng, Sulin; Kujala, Urho; Suominen, Harri; Alén, Markku; Puolakka, Jukka; Ankarberg-Lindgren, Carina; Ronkainen, Paula; Koskenvuo, Markku; Kaprio, Jaakko; Rantanen, Taina; Sipilä, Sarianna (Wiley Blackwell, 2011)Although postmenopausal hormone-replacement therapy (HRT) is known to prevent fractures, knowledge on the influence of long-term HRT on bone strength and its determinants other than areal bone mineral density is scarce. ... -
Power training and postmenopausal hormone therapy affect transcriptional control of specific co-regulated gene clusters in skeletal muscle
Pöllänen, Eija; Fey, Vidal; Törmäkangas, Timo; Ronkainen, Paula; Taaffe, Dennis; Takala, Timo; Koskinen, Satu; Cheng, Sulin; Puolakka, Jukka; Kujala, Urho; Suominen, Harri; Sipilä, Sarianna; Kovanen, Vuokko (Springer, 2010)At the moment, there is no clear molecular explanation for the steeper decline in muscle performance after menopause or the mechanisms of counteractive treatments. The goal of this genome-wide study was to identify the ... -
Global gene expression profiles in skeletal muscle of monozygotic female twins discordant for hormone replacement therapy.
Ronkainen, Paula; Laakkonen, Eija; Alén, Markku; Pitkänen, Reino; Puolakka, Jukka; Kujala, Urho; Kaprio, Jaakko; Sipilä, Sarianna; Kovanen, Vuokko (Blackwell Publishing Ltd/Anatomical Society of Great Britain and Ireland, 2010)Aging is accompanied by inexorable loss of muscle tissue. One of the underlying causes for this is the massive change in the hormonal milieu of the body. The role of a female sex steroid – estrogen – in these processes is ... -
Regulation of gene expression and steroidogenesis in skeletal muscle of postmenopausal women : with emphasis on the effects of hormone replacement and power training
Pöllänen, Eija (University of Jyväskylä, 2011) -
Effects of combined hormone replacement therapy or its effective agents on the IGF-1 pathway in skeletal muscle
Pöllänen, Eija; Ronkainen, Paula; Horttanainen, Mia; Takala, Timo; Puolakka, Jukka; Suominen, Harri; Sipilä, Sarianna; Kovanen, Vuokko (Churchill Livingstone, 2010)Objectives To investigate the effects of combined hormone replacement therapy (HRT) and its effective agents on the IGF-1 signaling pathway. Design and methods To examine the effects of HRT on skeletal muscle in ...
Ellei toisin mainittu, julkisesti saatavilla olevia JYX-metatietoja (poislukien tiivistelmät) saa vapaasti uudelleenkäyttää CC0-lisenssillä.