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dc.contributor.authorLaakkonen, Eija
dc.contributor.authorSipilä, Sarianna
dc.contributor.authorAlén, Markku
dc.contributor.authorRonkainen, Paula
dc.contributor.authorAnkarberg-Lindgren, Carina
dc.contributor.authorPuolakka, Jukka
dc.contributor.authorSuominen, Harri
dc.contributor.authorHämäläinen, Esa
dc.contributor.authorTurpeinen, Ursula
dc.contributor.authorKonttinen, Yrjö
dc.contributor.authorKovanen, Vuokko
dc.date.accessioned2017-03-24T11:13:15Z
dc.date.available2017-03-24T11:13:15Z
dc.date.issued2011
dc.identifier.citationLaakkonen, E., Sipilä, S., Alén, M., Ronkainen, P., Ankarberg-Lindgren, C., Puolakka, J., Suominen, H., Hämäläinen, E., Turpeinen, U., Konttinen, Y., & Kovanen, V. (2011). DIFFERENTIAL INFLUENCE OF PERIPHERAL AND SYSTEMIC SEX STEROIDS ON SKELETAL MUSCLE QUALITY IN PRE- AND POSTMENOPAUSAL WOMEN.. <i>Aging Cell</i>, <i>10</i>(4), 650-660. <a href="https://doi.org/10.1111/j1474-9726.2011.00701.x." target="_blank">https://doi.org/10.1111/j1474-9726.2011.00701.x.</a>
dc.identifier.otherCONVID_20323151
dc.identifier.otherTUTKAID_45296
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/53358
dc.description.abstractAging is associated with gradual decline of skeletal muscle strength and mass often leading to diminished muscle quality. This phenomenon is known as sarcopenia and affects about 30% of the over 60-year-old population. Androgens act as anabolic agents regulating muscle mass and improving muscle performance. The role of female sex steroids as well as the ability of skeletal muscle tissue to locally produce sex steroids has been less extensively studied. We show that despite the extensive systemic deficit of sex steroid hormones in postmenopausal compared to premenopausal women, the hormone content of skeletal muscle does not follow the same trend. In contrast to the systemic levels, muscle tissue of post- and premenopausal women had similar concentrations of dehydroepiandrosterone and androstenedione, while the concentrations of estradiol and testosterone were signifi- cantly higher in muscle of the postmenopausal women. The presence of steroidogenetic enzymes in muscle tissue indicates that the elevated postmenopausal steroid levels in skeletal muscle are because of local steroidogenesis. The circulating sex steroids were associated with better muscle quality while the muscle concentrations reflected the amount of infiltrated fat within muscle tissue. We conclude that systemically delivered and peripherally produced sex steroids have distinct roles in the regulation of neuromuscular characteristics during aging. Key words: endocrine effects of steroid hormones; intracrinology of skeletal muscle; localization of steroidogenic enzymes; menopause; paracrine effects of steroid hormones; systemic and local steroidogenesis.
dc.language.isoeng
dc.publisherBlackwell Publishing Ltd/Anatomical Society of Great Britain and Ireland
dc.relation.ispartofseriesAging Cell
dc.subject.otherpaikallinen ja systeeminen steroidogeneesi
dc.subject.otherluustolihas
dc.subject.otherlocal and systemic steroidogenesis
dc.subject.otherskeletal muscle
dc.titleDIFFERENTIAL INFLUENCE OF PERIPHERAL AND SYSTEMIC SEX STEROIDS ON SKELETAL MUSCLE QUALITY IN PRE- AND POSTMENOPAUSAL WOMEN.
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201703211716
dc.contributor.laitosTerveystieteiden laitosfi
dc.contributor.laitosDepartment of Health Sciencesen
dc.contributor.oppiaineGerontologia ja kansanterveysfi
dc.contributor.oppiaineGerontology and Public Healthen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2017-03-21T10:15:12Z
dc.type.coarjournal article
dc.description.reviewstatuspeerReviewed
dc.format.pagerange650-660
dc.relation.issn1474-9726
dc.relation.numberinseries4
dc.relation.volume10
dc.type.versionpublishedVersion
dc.rights.copyright© 2011 The Authors Aging Cell © 2011 Blackwell Publishing Ltd/Anatomical Society of Great Britain and Ireland.
dc.rights.accesslevelopenAccessfi
dc.subject.ysonaiset
dc.subject.ysovaihdevuodet
dc.subject.ysoikä
jyx.subject.urihttp://www.yso.fi/onto/yso/p16991
jyx.subject.urihttp://www.yso.fi/onto/yso/p17397
jyx.subject.urihttp://www.yso.fi/onto/yso/p1229
dc.relation.doi10.1111/j1474-9726.2011.00701.x.


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