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Postmenopausal Hormone Replacement Therapy Modifies Skeletal Muscle Composition and Function: A Study with Monozygotic Twin Pairs

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Ronkainen, P., Kovanen, V., Alén, M., Laakkonen, E., Palonen, E.-M., Ankarberg-Lindgren, C., Hämäläinen, E., Turpeinen, U., Kujala, U., Puolakka, J., Kaprio, J., & Sipilä, S. (2009). Postmenopausal Hormone Replacement Therapy Modifies Skeletal Muscle Composition and Function: A Study with Monozygotic Twin Pairs. The Journal of Applied Physiology, 107(1), 25-33. https://doi.org/10.1152/japplphysiol.91518.2008
Published in
The Journal of Applied Physiology
Authors
Ronkainen, Paula |
Kovanen, Vuokko |
Alén, Markku |
Laakkonen, Eija |
Palonen, Eeva-Maija |
Ankarberg-Lindgren, Carina |
Hämäläinen, Esa |
Turpeinen, Ursula |
Kujala, Urho |
Puolakka, Jukka |
Kaprio, Jaakko |
Sipilä, Sarianna
Date
2009
Discipline
Gerontologia ja kansanterveysGerontologian tutkimuskeskusHyvinvoinnin tutkimuksen yhteisöGerontology and Public HealthGerontology Research CenterSchool of Wellbeing
Copyright
© 2009 the American Physiological Society. This is a final draft version of an article whose final and definitive form has been published by APS. Published in this repository with the kind permission of the publisher.

 
We investigated whether long-term hormone replacement therapy (HRT) is associated with mobility and lower limb muscle performance and composition in postmenopausal women. Fifteen 54- to 62-yr-old monozygotic female twin pairs discordant for HRT were recruited from the Finnish Twin Cohort. Habitual (HWS) and maximal (MWS) walking speeds over 10 m, thigh muscle composition, lower body muscle power assessed as vertical jumping height, and maximal isometric hand grip and knee extension strengths were measured. Intrapair differences (IPD%) with 95% confidence intervals (CI) were calculated. The mean duration of HRT use was 6.9 ± 4.1 yr. MWS was on average 7% (0.9 to 13.1%, P = 0.019) and muscle power 16% (−0.8 to 32.8%, P = 0.023) greater in HRT users than in their cotwins. Thigh muscle cross-sectional area tended to be larger (IPD% = 6%, 95% CI: −0.07 to 12.1%, P = 0.065), relative muscle area greater (IPD% = 8%, CI: 0.8 to 15.0%, P = 0.047), and relative fat area smaller (IPD% = −5%, CI: −11.3 to 1.2%, P = 0.047) in HRT users than in their sisters. There were no significant differences in maximal isometric strengths or HWS between users and nonusers. Subgroup analyses revealed that estrogen-containing therapies (11 pairs) significantly decreased total body and thigh fat content, whereas tibolone (4 pairs) tended to increase muscle cross-sectional area. This study showed that long-term HRT was associated with better mobility, greater muscle power, and favorable body and muscle composition among 54- to 62-yr-old women. The results indicate that HRT is a potential agent in preventing muscle weakness and mobility limitation in older women. ...
Publisher
American Physiological Society
ISSN Search the Publication Forum
0522-1601
Keywords
Ikääntymien lihaksen voimantuottoteho Aging muscle power vaihdevuodet sukupuolihormonit lihasvoima
DOI
https://doi.org/10.1152/japplphysiol.91518.2008
URI

http://urn.fi/URN:NBN:fi:jyu-201705082236

Publication in research information system

https://converis.jyu.fi/converis/portal/detail/Publication/18632726

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  • Liikuntatieteiden tiedekunta [2599]

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