Estrogenic regulation of skeletal muscle proteome : a study of premenopausal women and postmenopausal MZ cotwins discordant for hormonal therapy
Laakkonen, E., Soliymani, R., Karvinen, S., Kaprio, J., Kujala, U., Baumann, M., Sipilä, S., Kovanen, V., & Lalowski, M. (2017). Estrogenic regulation of skeletal muscle proteome : a study of premenopausal women and postmenopausal MZ cotwins discordant for hormonal therapy. Aging Cell, 16(6), 1276-1287. https://doi.org/10.1111/acel.12661
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Aging CellAuthors
Date
2017Discipline
Gerontologia ja kansanterveysLiikuntafysiologiaLiikuntalääketiedeGerontology and Public HealthExercise PhysiologySports and Exercise MedicineCopyright
© 2017 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.
This is an open access article under the terms of the Creative Commons Attribution License.
Female middle age is characterized by a decline in skeletal muscle
mass and performance, predisposing women to sarcopenia,
functional limitations, and metabolic dysfunction as they age.
Menopausal loss of ovarian function leading to low circulating
level of 17b-estradiol has been suggested as a contributing factor
to aging-related muscle deterioration. However, the underlying
molecular mechanisms remain largely unknown and thus far
androgens have been considered as a major anabolic hormone
for skeletal muscle. We utilized muscle samples from 24 pre- and
postmenopausal women to establish proteome-wide profiles,
associated with the difference in age (30–34 years old vs. 54–
62 years old), menopausal status (premenopausal vs. postmenopausal),
and use of hormone replacement therapy (HRT;
user vs. nonuser). None of the premenopausal women used
hormonal medication while the postmenopausal women were
monozygotic (MZ) cotwin pairs of whom the other sister was
current HRT user or the other had never used HRT. Label-free
proteomic analyses resulted in the quantification of 797 muscle
proteins of which 145 proteins were for the first time associated
with female aging using proteomics. Furthermore, we identified
17b-estradiol as a potential upstream regulator of the observed
differences in muscle energy pathways. These findings pinpoint
the underlying molecular mechanisms of the metabolic dysfunction
accruing upon menopause, thus having implications for
understanding the complex functional interactions between
female reproductive hormones and health.
...


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Wiley-Blackwell Publishing LtdISSN Search the Publication Forum
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Except where otherwise noted, this item's license is described as © 2017 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.
This is an open access article under the terms of the Creative Commons Attribution License.
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