DIFFERENTIAL INFLUENCE OF PERIPHERAL AND SYSTEMIC SEX STEROIDS ON SKELETAL MUSCLE QUALITY IN PRE- AND POSTMENOPAUSAL WOMEN.
Laakkonen, E., Sipilä, S., Alén, M., Ronkainen, P., Ankarberg-Lindgren, C., Puolakka, J., Suominen, H., Hämäläinen, E., Turpeinen, U., Konttinen, Y., & Kovanen, V. (2011). DIFFERENTIAL INFLUENCE OF PERIPHERAL AND SYSTEMIC SEX STEROIDS ON SKELETAL MUSCLE QUALITY IN PRE- AND POSTMENOPAUSAL WOMEN.. Aging Cell, 10(4), 650-660. https://doi.org/10.1111/j1474-9726.2011.00701.x.
Published in
Aging CellAuthors
Date
2011Discipline
Gerontologia ja kansanterveysGerontologian tutkimuskeskusHyvinvoinnin tutkimuksen yhteisöGerontology and Public HealthGerontology Research CenterSchool of WellbeingCopyright
© 2011 The Authors Aging Cell © 2011 Blackwell Publishing Ltd/Anatomical Society of Great Britain and Ireland.
Aging is associated with gradual decline of skeletal muscle
strength and mass often leading to diminished muscle
quality. This phenomenon is known as sarcopenia and
affects about 30% of the over 60-year-old population.
Androgens act as anabolic agents regulating muscle mass
and improving muscle performance. The role of female
sex steroids as well as the ability of skeletal muscle tissue
to locally produce sex steroids has been less extensively
studied. We show that despite the extensive systemic deficit
of sex steroid hormones in postmenopausal compared
to premenopausal women, the hormone content of
skeletal muscle does not follow the same trend. In contrast
to the systemic levels, muscle tissue of post- and
premenopausal women had similar concentrations of
dehydroepiandrosterone and androstenedione, while the
concentrations of estradiol and testosterone were signifi-
cantly higher in muscle of the postmenopausal women.
The presence of steroidogenetic enzymes in muscle tissue
indicates that the elevated postmenopausal steroid levels
in skeletal muscle are because of local steroidogenesis.
The circulating sex steroids were associated with better muscle quality while the muscle concentrations reflected
the amount of infiltrated fat within muscle tissue. We
conclude that systemically delivered and peripherally produced
sex steroids have distinct roles in the regulation of
neuromuscular characteristics during aging.
Key words: endocrine effects of steroid hormones; intracrinology
of skeletal muscle; localization of steroidogenic
enzymes; menopause; paracrine effects of steroid hormones;
systemic and local steroidogenesis.
...
Publisher
Blackwell Publishing Ltd/Anatomical Society of Great Britain and IrelandISSN Search the Publication Forum
1474-9726Keywords
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