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dc.contributor.authorRonkainen, Paula
dc.contributor.authorLaakkonen, Eija
dc.contributor.authorAlén, Markku
dc.contributor.authorPitkänen, Reino
dc.contributor.authorPuolakka, Jukka
dc.contributor.authorKujala, Urho
dc.contributor.authorKaprio, Jaakko
dc.contributor.authorSipilä, Sarianna
dc.contributor.authorKovanen, Vuokko
dc.date.accessioned2017-03-21T11:31:42Z
dc.date.available2017-03-21T11:31:42Z
dc.date.issued2010
dc.identifier.citationRonkainen, P., Laakkonen, E., Alén, M., Pitkänen, R., Puolakka, J., Kujala, U., . . . Kovanen, V. (2010). Global gene expression profiles in skeletal muscle of monozygotic female twins discordant for hormone replacement therapy. <em>Aging Cell</em>, 9 (6), 1098-1110. <a href="https://doi.org/10.1111/j.1474-9726.2010.00636.x">doi:10.1111/j.1474-9726.2010.00636.x</a>
dc.identifier.otherTUTKAID_42145
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/53334
dc.description.abstractAging is accompanied by inexorable loss of muscle tissue. One of the underlying causes for this is the massive change in the hormonal milieu of the body. The role of a female sex steroid – estrogen – in these processes is frequently neglected, although the rapid decline in its production coincides with a steep deterioration in muscle performance. We recruited 54- to 62-year-old monozygotic female twin pairs discordant for postmenopausal hormone replacement therapy (HRT, n = 11 pairs; HRT use 7.3 ± 3.7 years) from the Finnish Twin Cohort to investigate the association of long-term, estrogen-based HRT with skeletal muscle transcriptome. Pathway analysis of muscle transcript profiles revealed significant HRT-induced up-regulation of a biological process related to regulation of cell structure and down-regulation of processes concerning, for example, cell–matrix interactions, energy metabolism and utilization of nutrients (false discovery rate < 0.15). Lending clinical relevance to the findings, these processes explained a significant fraction of the differences observed in relative proportion of muscle within thigh and in muscle performance (R2 = 0.180–0.257, P = 0.001–0.023). Although energy metabolism was affected through down-regulation of the transcripts related to succinate dehydrogenase complex in mitochondria, no differences were observed in mtDNA copy number or oxidative capacity per muscle cross section. In conclusion, long-term use of HRT was associated with subtle, but significant, differences in muscle transcript profiles. The better muscle composition and performance among the HRT users appeared to be orchestrated by improved regulatory actions on cytoskeleton, preservation of muscle quality via regulation of intramuscular extracellular matrix and a switch from glucose-oriented metabolism to utilization of fatty acids.
dc.language.isoeng
dc.publisherBlackwell Publishing Ltd/Anatomical Society of Great Britain and Ireland
dc.relation.ispartofseriesAging Cell
dc.subject.otherhormonikorvaushoito
dc.subject.othervaihdevuodet
dc.subject.otheridenttiset kaksoset
dc.subject.otherluustolihas
dc.subject.othergeeniekspressio
dc.subject.otherHormone replacement therapy
dc.subject.otherpostmenopause
dc.subject.otheridentical twins
dc.subject.otherskeletal muscle
dc.subject.otherglobal gene expression
dc.titleGlobal gene expression profiles in skeletal muscle of monozygotic female twins discordant for hormone replacement therapy
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201703211717
dc.contributor.laitosTerveystieteiden laitosfi
dc.contributor.laitosDepartment of Health Sciencesen
dc.contributor.oppiaineGerontologia ja kansanterveys
dc.contributor.oppiaineLiikuntalääketiede
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2017-03-21T10:15:17Z
dc.type.coarjournal article
dc.description.reviewstatuspeerReviewed
dc.format.pagerange1098-1110
dc.relation.issn1474-9718
dc.relation.volume9
dc.type.versionpublishedVersion
dc.rights.copyright© 2010 The Authors Aging Cell © 2010 Blackwell Publishing Ltd/Anatomical Society of Great Britain and Ireland. This is an open access article distributed under the terms of a Creative Commons License.
dc.rights.accesslevelopenAccessfi
dc.rights.urlhttps://creativecommons.org/licenses/by/3.0/
dc.relation.doi10.1111/j.1474-9726.2010.00636.x


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© 2010 The Authors Aging Cell © 2010 Blackwell Publishing Ltd/Anatomical Society of Great Britain and Ireland. This is an open access article distributed under the terms of a Creative Commons License.
Except where otherwise noted, this item's license is described as © 2010 The Authors Aging Cell © 2010 Blackwell Publishing Ltd/Anatomical Society of Great Britain and Ireland. This is an open access article distributed under the terms of a Creative Commons License.