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dc.contributor.authorTan, Xiao
dc.contributor.authorSaarinen, Antti
dc.contributor.authorMikkola, Tuija
dc.contributor.authorTenhunen, Jarkko
dc.contributor.authorMartinmäki, Samu
dc.contributor.authorRahikainen, Aki
dc.contributor.authorCheng, Shumei
dc.contributor.authorEklund, Niklas
dc.contributor.authorPekkala, Satu
dc.contributor.authorWiklund, Petri
dc.contributor.authorMunukka, Eveliina
dc.contributor.authorWen, Xinfei
dc.contributor.authorCong, Fengyu
dc.contributor.authorWang, Xi
dc.contributor.authorZhang, Yajun
dc.contributor.authorTarkka, Ina
dc.contributor.authorSun, Yining
dc.contributor.authorPartinen, Markku
dc.contributor.authorAlén, Markku
dc.contributor.authorCheng, Sulin
dc.date.accessioned2013-10-09T07:15:51Z
dc.date.available2013-10-09T07:15:51Z
dc.date.issued2013
dc.identifier.citationTan, X., Saarinen, A., Mikkola, T., Tenhunen, J., Martinmäki, S., Rahikainen, A., Cheng, S., Eklund, N., Pekkala, S., Wiklund, P., Munukka, E., Wen, X., Cong, F., Wang, X., Zhang, Y., Tarkka, I., Sun, Y., Partinen, M., Alén, M., & Cheng, S. (2013). Effects of exercise and diet interventions on obesity-related sleep disorders in men: study protocol for a randomized controlled trial. <i>Trials</i>, <i>14</i>(1), 235. <a href="https://doi.org/10.1186/1745-6215-14-235" target="_blank">https://doi.org/10.1186/1745-6215-14-235</a>
dc.identifier.otherCONVID_22780203
dc.identifier.otherTUTKAID_57509
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/42310
dc.description.abstractBackground. Sleep is essential for normal and healthy living. Lack of good quality sleep affects physical, mental and emotional functions. Currently, the treatments of obesity-related sleep disorders focus more on suppressing sleep-related symptoms pharmaceutically and are often accompanied by side effects. Thus, there is urgent need for alternative ways to combat chronic sleep disorders. This study will investigate underlying mechanisms of the effects of exercise and diet intervention on obesity-related sleep disorders, the role of gut microbiota in relation to poor quality of sleep and day-time sleepiness, as well as the levels of hormones responsible for sleep-wake cycle regulation. Methods/design. Participants consist of 330 (target sample) Finnish men aged 30 to 65 years. Among them, we attempt to randomize 180 (target sample) with sleep disorders into exercise and diet intervention. After screening and physician examination, 101 men with sleep disorders are included and are randomly assigned into three groups: exercise (n = 33), diet (n = 35), and control (n = 33). In addition, we attempt to recruit a target number of 150 healthy men without sleep disorders as the reference group. The exercise group undergoes a six-month individualized progressive aerobic exercise program based on initial fitness level. The diet group follows a six month specific individualized diet program. The control group and reference group are asked to maintain their normal activity and diet during intervention. Measurements are taken before and after the intervention. Primary outcomes include objective sleep measurements by polysomnography and a home-based non-contact sleep monitoring system, and subjective sleep evaluation by questionnaires. Secondary outcome measures include anthropometry, body composition, fitness, sleep disorder-related lifestyle risk factors, composition of gut microbiota and adipose tissue metabolism, as well as specific hormone and neurotranmitter levels and inflammatory biomarkers from venous blood samples. Discussion. It is expected that the improvement of sleep quality after exercise and diet intervention will be evident both in subjective and objective measures of quality of sleep. Additionally, the change of sleep quality induced by exercise and diet intervention is expected to be related to the changes in specific hormones and inflammatory biomarkers, and in the composition of gut microbiota. Trial registration. Current Controlled Trials ISRCTN77172005.fi
dc.language.isoeng
dc.publisherBioMed Central
dc.relation.ispartofseriesTrials
dc.relation.urihttp://www.trialsjournal.com/content/14/1/235
dc.subject.otherLifestyle intervention
dc.subject.otherQuality of sleep
dc.subject.otherObstructive sleep apnea
dc.subject.otherSleep measurement
dc.subject.otherGut microbiota
dc.subject.otherNeurotransmitters
dc.titleEffects of exercise and diet interventions on obesity-related sleep disorders in men: study protocol for a randomized controlled trial
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201310092442
dc.contributor.laitosTerveystieteiden laitosfi
dc.contributor.laitosTietotekniikan laitosfi
dc.contributor.laitosDepartment of Health Sciencesen
dc.contributor.laitosDepartment of Mathematical Information Technologyen
dc.contributor.oppiaineKognitiotiedefi
dc.contributor.oppiaineTietotekniikkafi
dc.contributor.oppiaineLiikuntalääketiedefi
dc.contributor.oppiaineCognitive Scienceen
dc.contributor.oppiaineMathematical Information Technologyen
dc.contributor.oppiaineSports and Exercise Medicineen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2013-10-09T03:30:17Z
dc.type.coarjournal article
dc.description.reviewstatuspeerReviewed
dc.format.pagerange235
dc.relation.issn1745-6215
dc.relation.numberinseries1
dc.relation.volume14
dc.type.versionpublishedVersion
dc.rights.copyright© 2013 Tan et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.rights.accesslevelopenAccessfi
dc.subject.ysounihäiriöt
dc.subject.ysounettomuus
dc.subject.ysolihavuus
jyx.subject.urihttp://www.yso.fi/onto/yso/p4600
jyx.subject.urihttp://www.yso.fi/onto/yso/p26927
jyx.subject.urihttp://www.yso.fi/onto/yso/p823
dc.rights.urlhttp://creativecommons.org/licenses/by/2.0
dc.relation.doi10.1186/1745-6215-14-235


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© 2013 Tan et al.; licensee BioMed Central Ltd. 


This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Except where otherwise noted, this item's license is described as © 2013 Tan et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.