Effect of aerobic exercise and low carbohydrate diet on pre-diabetic non-alcoholic fatty liver disease in postmenopausal women and middle aged men: study protocol for the AELC randomized controlled trial
Liu, W. Y., Lu, D. J., Du, X. M., Sun, J. Q., Ge, J., Wang, R. W., Wang, R., Zou, J., Xu, C., Ren, J., Wen, X. F., Liu, Y., Cheng, S., Tan, X., Pekkala, S., Munukka, E., Wiklund, P., Chen, Y. Q., Gu, Q., . . . Cheng, S. (2014). Effect of aerobic exercise and low carbohydrate diet on pre-diabetic non-alcoholic fatty liver disease in postmenopausal women and middle aged men: study protocol for the AELC randomized controlled trial. BMC Public Health, 14(48). https://doi.org/10.1186/1471-2458-14-48
Published inBMC Public Health
Ge, Jun |
Wang, Ru |
Zou, Jun |
Ren, Jie |
Gu, Qing |
Li, Rui |
DisciplineLiikuntalääketiedeTerveyskasvatusSports and Exercise MedicineHealth Promotion and Health Education
© 2014 Liu et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Background. Pre-diabetes and non-alcoholic fatty liver disease (NAFLD) are associated with an unhealthy lifestyle and pose extremely high costs to the healthcare system. In this study, we aim to explore whether individualized aerobic exercise (AEx) and low carbohydrate diet (LCh) intervention affect hepatic fat content (HFC) in pre-diabetes via modification of gut microbiota composition and other post-interventional effects. Methods/design. A 6-month randomized intervention with 6-month follow-up is conducted from January 2013 to December 2015. The target sample size for intervention is 200 postmenopausal women and middle-aged men aged 50–65 year-old with pre-diabetes and NAFLD. The qualified subjects are randomized into 4 groups with 50 subjects in each group: 1 = AEx, 2 = LCh, 3 = AEx + LCh, and 4 = control. In addition, two age-matched reference groups (5 = pre-diabetes without NAFLD (n = 50) and 6 = Healthy without pre-diabetes or NAFLD (n = 50)) are included. The exercise program consists of progressive and variable aerobic exercise (intensity of 60 to 75% of initial fitness level, 3–5 times/week and 30–60 min/time). The diet program includes dietary consultation plus supplementation with a special lunch meal (40% of total energy intake/day) which aims to reduce the amount of carbohydrate consumption (30%). The control and reference groups are advised to maintain their habitual habits during the intervention. The primary outcome measures are HFC, serum metabolomics and gut microbiota composition. The secondary outcome measures include body composition and cytokines. In addition, socio-psychological aspects, social support, physical activity and diet will be performed by means of questionnaire and interview. Discussion. Specific individualized exercise and diet intervention in this study offers a more efficient approach for liver fat reduction and diabetes prevention via modification of gut microbiota composition. Besides, the study explores the importance of incorporating fitness assessment and exercise in the management of patients with pre-diabetes and fatty liver disorders. If our program is shown to be effective, it will open new strategies to combat these chronic diseases. ...
Publication in research information system
MetadataShow full item record
- Liikuntatieteiden tiedekunta 
Except where otherwise noted, this item's license is described as © 2014 Liu et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Showing items with similar title or keywords.
The Impact of Nordic Walking on Bone Properties in Postmenopausal Women with Pre-Diabetes and Non-Alcohol Fatty Liver Disease Du, Xiaming; Zhang, Chao; Zhang, Xiangqi; Qi, Zhen; Cheng, Sulin; Le, Shenglong (MDPI AG, 2021)This study investigated the impact of Nordic walking on bone properties in postmenopausal women with pre-diabetes and non-alcohol fatty liver disease (NAFLD). A total of 63 eligible women randomly participated in the Nordic ...
Effects of exercise and diet interventions on obesity-related sleep disorders in men: study protocol for a randomized controlled trial Tan, Xiao; Saarinen, Antti; Mikkola, Tuija; Tenhunen, Jarkko; Martinmäki, Samu; Rahikainen, Aki; Cheng, Shumei; Eklund, Niklas; Pekkala, Satu; Wiklund, Petri; Munukka, Eveliina; Wen, Xinfei; Cong, Fengyu; Wang, Xi; Zhang, Yajun; Tarkka, Ina; Sun, Yining; Partinen, Markku; Alén, Markku; Cheng, Sulin (BioMed Central, 2013)Background. Sleep is essential for normal and healthy living. Lack of good quality sleep affects physical, mental and emotional functions. Currently, the treatments of obesity-related sleep disorders focus more on ...
Intrinsic aerobic capacity governs the associations between gut microbiota composition and fat metabolism age-dependently in rat siblings Pekkala, Satu; Lensu, Sanna; Nokia, Miriam; Vanhatalo, Sanja; Koch, Lauren G.; Britton, Steven L.; Kainulainen, Heikki (American Physiological Society, 2017)Host genetic factors affecting the gut microbiome play an important role in obesity, yet limited attention has been paid on the host genetic factors linked to physical fitness in modifying the microbiome. This study ...
Gao, Ying; Silvennoinen, Mika; Pesola, Arto; Kainulainen, Heikki; Cronin, Neil; Finni Juutinen, Taija (American College of Sports Medicine; Lippincott Williams & Wilkins, 2017)Purpose While merely standing up interrupts sedentary behavior, it is important to study acute metabolic responses during single bouts of sitting and standing to understand the physiological processes affecting the health ...
Six-Week Endurance Exercise Alters Gut Metagenome That Is not Reflected in Systemic Metabolism in Over-weight Women Munukka, Eveliina; Ahtiainen, Juha; Puigbo, Pere; Jalkanen, Sirpa; Pahkala, Katja; Rintala, Anniina; Kujala, Urho; Pietilä, Sami; Hollmén, Maija; Elo, Laura; Huovinen, Pentti; D'Auria, Giuseppe; Pekkala, Satu (Frontiers Research Foundation, 2018)Recent studies suggest that exercise alters the gut microbiome. We determined whether six-weeks endurance exercise, without changing diet, affected the gut metagenome and systemic metabolites of overweight women. Previously ...