Effect of aerobic exercise and diet on liver fat in pre-diabetic patients with non-alcoholic-fatty-liver-disease: A randomized controlled trial
Cheng, S., Ge, J., Zhao, C., Le, S., Yang, Y., Ke, D., Wu, N., Tan, X., Zhang, X., Du, X., Sun, J., Wang, R., Shi, Y., Borra, R. J. H., Parkkola, R., Wiklund, P., & Lu, D. (2017). Effect of aerobic exercise and diet on liver fat in pre-diabetic patients with non-alcoholic-fatty-liver-disease: A randomized controlled trial. Scientific Reports, 7, Article 15952. https://doi.org/10.1038/s41598-017-16159-x
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Scientific ReportsDate
2017Copyright
© the Authors, 2017. This article is licensed under a Creative Commons Attribution 4.0 International License.
The study aimed to assess whether aerobic exercise (AEx) training and a fbre-enriched diet can reduce
hepatic fat content (HFC) and increase glycaemic control in pre-diabetic patients with non-alcoholic
fatty liver disease (NAFLD). Six-hundred-and-three patients from seven clinics in Yangpu district,
Shanghai, China were recruited. Of them 115 individuals aged 50–65-year fulflled the inclusion criteria
(NAFLD with impaired fasting glucose or impaired glucose tolerance) and were randomly assigned into
exercise (AEx n=29), diet (Diet n=28), exercise plus diet (AED n=29), or no-intervention (NI n=29)
groups. Progressive supervised AEx training (60–75% VO2max intensity) was given 2-3 times/week in
30–60min/sessions, and the diet intervention was provided as lunch with 38% carbohydrate and diet
fbre of 12g/day for 8.6-month. HFC was assessed by 1H MRS. We found that HFC was signifcantly
reduced in the AEx (−24.4%), diet (−23.2%), and AED (−47.9%) groups by contrast to the 20.9%
increase in the NI group (p=0.001 for all) after intervention. However, only AED group signifcantly
decreased HbA1c (−4.4%, p=0.01) compared with the NI group (−0.6%). Aerobic exercise training
combined with fbre-enriched diet can reduce HFC more efectively than either exercise or increased
fbre-intake alone in pre-diabetic patients with NAFLD.
...
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Except where otherwise noted, this item's license is described as © the Authors, 2017. This article is licensed under a Creative Commons Attribution 4.0 International License.
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