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dc.contributor.authorCheng, Sulin
dc.contributor.authorGe, Jun
dc.contributor.authorZhao, Can
dc.contributor.authorLe, Shenglong
dc.contributor.authorYang, Yifan
dc.contributor.authorKe, Dandan
dc.contributor.authorWu, Na
dc.contributor.authorTan, Xiao
dc.contributor.authorZhang, Xiaobo
dc.contributor.authorDu, Xiaming
dc.contributor.authorSun, Jianqin
dc.contributor.authorWang, Renwei
dc.contributor.authorShi, Yongyong
dc.contributor.authorBorra, Ronald J. H.
dc.contributor.authorParkkola, Riitta
dc.contributor.authorWiklund, Petri
dc.contributor.authorLu, Dajiang
dc.date.accessioned2017-12-01T09:05:54Z
dc.date.available2017-12-01T09:05:54Z
dc.date.issued2017
dc.identifier.citationCheng, S., Ge, J., Zhao, C., Le, S., Yang, Y., Ke, D., . . . Lu, D. (2017). Effect of aerobic exercise and diet on liver fat in pre-diabetic patients with non-alcoholic-fatty-liver-disease: A randomized controlled trial. <em>Scientific Reports</em>, 7, 15952. <a href="https://doi.org/10.1038/s41598-017-16159-x">doi:10.1038/s41598-017-16159-x</a>
dc.identifier.otherTUTKAID_75863
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/56077
dc.description.abstractThe study aimed to assess whether aerobic exercise (AEx) training and a fbre-enriched diet can reduce hepatic fat content (HFC) and increase glycaemic control in pre-diabetic patients with non-alcoholic fatty liver disease (NAFLD). Six-hundred-and-three patients from seven clinics in Yangpu district, Shanghai, China were recruited. Of them 115 individuals aged 50–65-year fulflled the inclusion criteria (NAFLD with impaired fasting glucose or impaired glucose tolerance) and were randomly assigned into exercise (AEx n=29), diet (Diet n=28), exercise plus diet (AED n=29), or no-intervention (NI n=29) groups. Progressive supervised AEx training (60–75% VO2max intensity) was given 2-3 times/week in 30–60min/sessions, and the diet intervention was provided as lunch with 38% carbohydrate and diet fbre of 12g/day for 8.6-month. HFC was assessed by 1H MRS. We found that HFC was signifcantly reduced in the AEx (−24.4%), diet (−23.2%), and AED (−47.9%) groups by contrast to the 20.9% increase in the NI group (p=0.001 for all) after intervention. However, only AED group signifcantly decreased HbA1c (−4.4%, p=0.01) compared with the NI group (−0.6%). Aerobic exercise training combined with fbre-enriched diet can reduce HFC more efectively than either exercise or increased fbre-intake alone in pre-diabetic patients with NAFLD.
dc.language.isoeng
dc.publisherNature Publishing Group
dc.relation.ispartofseriesScientific Reports
dc.subject.otheraerobinen harjoittelu
dc.subject.otherruokavaliot
dc.subject.otherravintokuitu
dc.subject.otherrasvamaksa
dc.subject.otheraerobic training
dc.subject.otherdiets
dc.subject.otherdietary fibre
dc.subject.otherfatty liver
dc.titleEffect of aerobic exercise and diet on liver fat in pre-diabetic patients with non-alcoholic-fatty-liver-disease: A randomized controlled trial
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201711244370
dc.contributor.laitosLiikuntatieteellinen tiedekuntafi
dc.contributor.laitosFaculty of Sport and Health Sciencesen
dc.contributor.oppiaineLiikuntalääketiede
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2017-11-24T13:15:32Z
dc.type.coarjournal article
dc.description.reviewstatuspeerReviewed
dc.relation.issn2045-2322
dc.relation.volume7
dc.type.versionpublishedVersion
dc.rights.copyright© the Authors, 2017. This article is licensed under a Creative Commons Attribution 4.0 International License.
dc.rights.accesslevelopenAccessfi
dc.rights.urlhttps://creativecommons.org/licenses/by/4.0/
dc.relation.doi10.1038/s41598-017-16159-x


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© the Authors, 2017. This article is licensed under a Creative Commons Attribution 4.0 International License.
Except where otherwise noted, this item's license is described as © the Authors, 2017. This article is licensed under a Creative Commons Attribution 4.0 International License.