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dc.contributor.authorPlaza-Florido, Abel
dc.contributor.authorEsteban-Cornejo, Irene
dc.contributor.authorMora-Gonzalez, Jose
dc.contributor.authorTorres-Lopez, Lucia, V.
dc.contributor.authorOsuna-Prieto, Francisco, J.
dc.contributor.authorGil-Cosano, Jose, J.
dc.contributor.authorRadom-Aizik, Shlomit
dc.contributor.authorLabayen, Idoia
dc.contributor.authorRuiz, Jonatan, R.
dc.contributor.authorAltmäe, Signe
dc.contributor.authorOrtega, Francisco, B.
dc.date.accessioned2023-11-13T10:27:05Z
dc.date.available2023-11-13T10:27:05Z
dc.date.issued2023
dc.identifier.citationPlaza-Florido, A., Esteban-Cornejo, I., Mora-Gonzalez, J., Torres-Lopez, L., Osuna-Prieto, F., Gil-Cosano, J., Radom-Aizik, S., Labayen, I., Ruiz, J., Altmäe, S., & Ortega, F. (2023). Gene–exercise interaction on brain health in children with overweight/obesity : the ActiveBrains randomized controlled trial. <i>Journal of Applied Physiology</i>, <i>135</i>, 775-785. <a href="https://doi.org/10.1152/japplphysiol.00435.2023" target="_blank">https://doi.org/10.1152/japplphysiol.00435.2023</a>
dc.identifier.otherCONVID_189065021
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/91905
dc.description.abstractWe investigated the interaction between a genetic score and an exercise intervention on brain health in children with over-weight/obesity. One hundred one children with overweight/obesity (10.0 ± 1.5 yr, 59% girls) were randomized into a 20-wkcombined exercise intervention or a control group. Several cognitive and academic outcomes were measured with validated tests. Hippocampal volume was quantified using magnetic resonance imaging. Six brain health-related polymorphisms [rs6265(BDNF), rs2253206 (CREB1), rs2289656 (NTRK2), rs4680 (COMT), rs429358, and rs7412 (APOE)] were genotyped. Cognitive flexibility and academic skills improved significantly more in the exercise than in the control group only in the children with a “favorable” genetic profile [meanz-score, 0.41–0.67 (95% CI 0.11 to 1.18)], yet not in those with “less favorable” genetic profile. An individual response analysis showed that children responded to exercise in cognitive flexibility only in the “genetically favorable” group [i.e., 62% of them had a meaningful ( 0.2 Cohend) increase in the exercise group compared with only 25%in the control group]. This finding was consistent in per-protocol and intention-to-treat analyses (P¼0.01 andP¼0.03, respectively). The results were not significant or not consistent for the rest of outcomes studied. Our findings suggest that having a more favorable genetic profile makes children with overweight/obesity more responsive to exercise, particularly for cognitive flexibility.en
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherAmerican Physiological Society
dc.relation.ispartofseriesJournal of Applied Physiology
dc.rightsIn Copyright
dc.subject.othergenetics
dc.subject.othercognition
dc.subject.otherfitness
dc.subject.otherpediatrics
dc.subject.otherphysical activity
dc.titleGene–exercise interaction on brain health in children with overweight/obesity : the ActiveBrains randomized controlled trial
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-202311137929
dc.contributor.laitosLiikuntatieteellinen tiedekuntafi
dc.contributor.laitosFaculty of Sport and Health Sciencesen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1
dc.description.reviewstatuspeerReviewed
dc.format.pagerange775-785
dc.relation.issn8750-7587
dc.relation.volume135
dc.type.versionacceptedVersion
dc.rights.copyright© 2023 the American Physiological Society.
dc.rights.accesslevelopenAccessfi
dc.subject.ysokognitio
dc.subject.ysolastentautioppi
dc.subject.ysoperinnöllisyystiede
dc.subject.ysofyysinen kunto
dc.subject.ysofyysinen aktiivisuus
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p642
jyx.subject.urihttp://www.yso.fi/onto/yso/p3629
jyx.subject.urihttp://www.yso.fi/onto/yso/p5147
jyx.subject.urihttp://www.yso.fi/onto/yso/p7384
jyx.subject.urihttp://www.yso.fi/onto/yso/p23102
dc.rights.urlhttp://rightsstatements.org/page/InC/1.0/?language=en
dc.relation.doi10.1152/japplphysiol.00435.2023
jyx.fundinginformationThe project was mainly funded by the Spanish Ministry of Economy and Competitiveness (Reference DEP2013-47540,DEP2016-79512-R, and DEP2017-91544-EXP) and by the Andalusian Operational Programme supported with European Regional Development Funds (ERDF in English, FEDER in Spanish, projects ref: B-CTS-355-UGR18 and A-CTS-614-UGR20) and Junta de Andalucia (P20_00158). Grant Endo-Map PID2021-12728OB-100funded by MCIN/AEI/10.13039/501100011033 and ERFD A way of making Europe; Grant RYC-2016-21199, funded by MCIN/AEI/10.13039/501100011033 and by ESF Investing in your future. This study was supported in part by the Pediatric Exercise and Genomics Research Center (PERC) Systems Biology Fund. A.P.-F. is supported in part by NIH Grant No.: U01 TR002004 (REACH project). I.E.-C. is supported by the Spanish Ministries of Economy and Competitiveness (RTI2018-095284-J-100), and Science and Innovation (RYC2019-027287-I). F.J.O.-P. is supported by Margarita Salas program (Programa de recualificaci on del profesorado Universitario, Ministerio de Universidades). Additional support was obtained from the Unit of Excellence on EXERNET Research Network on Exercise and Health (DEP2005- 00046/ACTI; 09/UPB/19; 45/UPB/20; 27/UPB/21); Alicia Koplowitz Foundation. This study has been partially funded by the University of Granada, Plan Propiode Investigacion 2016, Excellence actions: Units of Excellence; Unit of Excellence on Exercise and Health (UCEES), and by the Junta de Andalucía, Consejería de Conocimiento, Investigaciony Universidades and European Regional Development Fund(ERDF), ref. SOMM17/6107/UGR.
dc.type.okmA1


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