Age but not menopausal status is linked to lower resting energy expenditure
Karppinen, J. E., Wiklund, P., Ihalainen, J. K., Juppi, H.-K., Isola, V., Hyvärinen, M., Ahokas, E. K., Kujala, U. M., Laukkanen, J., Hulmi, J. J., Ahtiainen, J. P., Cheng, S., & Laakkonen, E. K. (2023). Age but not menopausal status is linked to lower resting energy expenditure. Journal of Clinical Endocrinology and Metabolism, 108(11), 2789-2797. https://doi.org/10.1210/clinem/dgad321
Published in
Journal of Clinical Endocrinology and MetabolismAuthors
Date
2023Discipline
LiikuntalääketiedeFyysinen aktiivisuus eliniän aikanaValmennus- ja testausoppiLiikuntafysiologiaGerontologia ja kansanterveysHyvinvoinnin tutkimuksen yhteisöBiomekaniikkaGerontologian tutkimuskeskusSports and Exercise MedicinePhysical activity through life spanScience of Sport Coaching and Fitness TestingExercise PhysiologyGerontology and Public HealthSchool of WellbeingBiomechanicsGerontology Research CenterCopyright
© 2023 the Authors
Context
It remains uncertain whether aging before late adulthood and menopause are associated with fat-free mass and fat mass–adjusted resting energy expenditure (REEadj).
Objectives
We investigated whether REEadj differs between middle-aged and younger women and between middle-aged women with different menopausal statuses. We repeated the age group comparison between middle-aged mothers and their daughters to partially control for genotype. We also explored whether serum estradiol and follicle-stimulating hormone concentrations explain REEadj in midlife.
Methods
We divided 120 women, including 16 mother–daughter pairs, into age groups; group I (n=26) consisted of participants aged 17–21, group II (n=35) of those aged 22–38 and group III (n=59) of those aged 41–58 years. The women in group III were further categorized as pre- or perimenopausal (n=19), postmenopausal (n=30) or postmenopausal hormone therapy users (n=10). REE was assessed using indirect calorimetry, body composition using dual-energy X-ray absorptiometry and hormones using immunoassays.
Results
The REEadj of group I was 126 kcal/d (95% CI: 93–160) higher than that of group III, and the REEadj of group II was 88 kcal/d (95% CI: 49–127) higher. Furthermore, daughters had a 100 kcal/d (95% CI: 63–138 kcal/d) higher REEadj than their middle-aged mothers (all P<0.001). In group III, REEadj was not lower in postmenopausal women and did not vary by sex hormone concentrations.
Conclusions
We demonstrated that REEadj declines with age in women before late adulthood, also when controlling partially for genetic background, and that menopause may not contribute to this decline.
...
Publisher
Oxford University Press; The Endocrine SocietyISSN Search the Publication Forum
0021-972XKeywords
Dataset(s) related to the publication
Laakkonen, Eija; Kovanen, Vuokko; Sipilä, Sarianna. (2022). Data from Estrogenic Regulation of Muscle Apoptosis (ERMA) study. University of Jyväskylä. https://doi.org/10.17011/jyx/dataset/83491. https://urn.fi/URN:NBN:fi:jyu-202210074820Publication in research information system
https://converis.jyu.fi/converis/portal/detail/Publication/183426657
Metadata
Show full item recordCollections
- Liikuntatieteiden tiedekunta [3076]
Related funder(s)
Research Council of Finland; Ministry of Education and CultureFunding program(s)
Research costs of Academy Research Fellow, AoF; Academy Project, AoF; Academy Research Fellow, AoF; OthersAdditional information about funding
Supported by the Academy of Finland grants 309504, 314181, 335249 (to EKL) and 135038 (to SC) and by the Ministry of Education and Culture of Finland grants OKM/54/627/2006, OKM/77/627/2008 (to SC) and OKM/10/626/2021 (to JKI). The manuscript preparation was supported by the Academy of Finland grant 330281 (to EKL). The contents of this article are solely the responsibility of the authors.License
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