dc.contributor.author | Karppinen, Jari E. | |
dc.contributor.author | Wiklund, Petri | |
dc.contributor.author | Ihalainen, Johanna K. | |
dc.contributor.author | Juppi, Hanna-Kaarina | |
dc.contributor.author | Isola, Ville | |
dc.contributor.author | Hyvärinen, Matti | |
dc.contributor.author | Ahokas, Essi K. | |
dc.contributor.author | Kujala, Urho M. | |
dc.contributor.author | Laukkanen, Jari | |
dc.contributor.author | Hulmi, Juha J. | |
dc.contributor.author | Ahtiainen, Juha P. | |
dc.contributor.author | Cheng, Sulin | |
dc.contributor.author | Laakkonen, Eija K. | |
dc.date.accessioned | 2023-10-27T10:32:28Z | |
dc.date.available | 2023-10-27T10:32:28Z | |
dc.date.issued | 2023 | |
dc.identifier.citation | Karppinen, J. E., Wiklund, P., Ihalainen, J. K., Juppi, H.-K., Isola, V., Hyvärinen, M., Ahokas, E. K., Kujala, U. M., Laukkanen, J., Hulmi, J. J., Ahtiainen, J. P., Cheng, S., & Laakkonen, E. K. (2023). Age but not menopausal status is linked to lower resting energy expenditure. <i>Journal of Clinical Endocrinology and Metabolism</i>, <i>108</i>(11), 2789-2797. <a href="https://doi.org/10.1210/clinem/dgad321" target="_blank">https://doi.org/10.1210/clinem/dgad321</a> | |
dc.identifier.other | CONVID_183426657 | |
dc.identifier.uri | https://jyx.jyu.fi/handle/123456789/90875 | |
dc.description.abstract | Context
It remains uncertain whether aging before late adulthood and menopause are associated with fat-free mass and fat mass–adjusted resting energy expenditure (REEadj).
Objectives
We investigated whether REEadj differs between middle-aged and younger women and between middle-aged women with different menopausal statuses. We repeated the age group comparison between middle-aged mothers and their daughters to partially control for genotype. We also explored whether serum estradiol and follicle-stimulating hormone concentrations explain REEadj in midlife.
Methods
We divided 120 women, including 16 mother–daughter pairs, into age groups; group I (n=26) consisted of participants aged 17–21, group II (n=35) of those aged 22–38 and group III (n=59) of those aged 41–58 years. The women in group III were further categorized as pre- or perimenopausal (n=19), postmenopausal (n=30) or postmenopausal hormone therapy users (n=10). REE was assessed using indirect calorimetry, body composition using dual-energy X-ray absorptiometry and hormones using immunoassays.
Results
The REEadj of group I was 126 kcal/d (95% CI: 93–160) higher than that of group III, and the REEadj of group II was 88 kcal/d (95% CI: 49–127) higher. Furthermore, daughters had a 100 kcal/d (95% CI: 63–138 kcal/d) higher REEadj than their middle-aged mothers (all P<0.001). In group III, REEadj was not lower in postmenopausal women and did not vary by sex hormone concentrations.
Conclusions
We demonstrated that REEadj declines with age in women before late adulthood, also when controlling partially for genetic background, and that menopause may not contribute to this decline. | en |
dc.format.mimetype | application/pdf | |
dc.language.iso | eng | |
dc.publisher | Oxford University Press; The Endocrine Society | |
dc.relation.ispartofseries | Journal of Clinical Endocrinology and Metabolism | |
dc.rights | CC BY 4.0 | |
dc.subject.other | resting energy expenditure | |
dc.subject.other | menopause | |
dc.subject.other | estrogen | |
dc.subject.other | hormone replacement therapy | |
dc.title | Age but not menopausal status is linked to lower resting energy expenditure | |
dc.type | article | |
dc.identifier.urn | URN:NBN:fi:jyu-202310276902 | |
dc.contributor.laitos | Liikuntatieteellinen tiedekunta | fi |
dc.contributor.laitos | Faculty of Sport and Health Sciences | en |
dc.contributor.oppiaine | Liikuntalääketiede | fi |
dc.contributor.oppiaine | Fyysinen aktiivisuus eliniän aikana | fi |
dc.contributor.oppiaine | Valmennus- ja testausoppi | fi |
dc.contributor.oppiaine | Liikuntafysiologia | fi |
dc.contributor.oppiaine | Gerontologia ja kansanterveys | fi |
dc.contributor.oppiaine | Hyvinvoinnin tutkimuksen yhteisö | fi |
dc.contributor.oppiaine | Biomekaniikka | fi |
dc.contributor.oppiaine | Gerontologian tutkimuskeskus | fi |
dc.contributor.oppiaine | Sports and Exercise Medicine | en |
dc.contributor.oppiaine | Physical activity through life span | en |
dc.contributor.oppiaine | Science of Sport Coaching and Fitness Testing | en |
dc.contributor.oppiaine | Exercise Physiology | en |
dc.contributor.oppiaine | Gerontology and Public Health | en |
dc.contributor.oppiaine | School of Wellbeing | en |
dc.contributor.oppiaine | Biomechanics | en |
dc.contributor.oppiaine | Gerontology Research Center | en |
dc.type.uri | http://purl.org/eprint/type/JournalArticle | |
dc.type.coar | http://purl.org/coar/resource_type/c_2df8fbb1 | |
dc.description.reviewstatus | peerReviewed | |
dc.format.pagerange | 2789-2797 | |
dc.relation.issn | 0021-972X | |
dc.relation.numberinseries | 11 | |
dc.relation.volume | 108 | |
dc.type.version | publishedVersion | |
dc.rights.copyright | © 2023 the Authors | |
dc.rights.accesslevel | openAccess | fi |
dc.relation.grantnumber | 314181 | |
dc.relation.grantnumber | 330281 | |
dc.relation.grantnumber | 309504 | |
dc.relation.grantnumber | OKM/10/626/2021, OKM/100/626/2021, OKM/78/626/2022 | |
dc.subject.yso | ikääntyminen | |
dc.subject.yso | energiankulutus (aineenvaihdunta) | |
dc.subject.yso | estrogeenit | |
dc.subject.yso | vaihdevuodet | |
dc.subject.yso | hormonaaliset tekijät | |
dc.subject.yso | naiset | |
dc.subject.yso | hormonihoito | |
dc.format.content | fulltext | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p5056 | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p24540 | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p16792 | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p17397 | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p21658 | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p16991 | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p980 | |
dc.rights.url | https://creativecommons.org/licenses/by/4.0/ | |
dc.relation.doi | 10.1210/clinem/dgad321 | |
dc.relation.funder | Research Council of Finland | en |
dc.relation.funder | Research Council of Finland | en |
dc.relation.funder | Research Council of Finland | en |
dc.relation.funder | Ministry of Education and Culture | en |
dc.relation.funder | Suomen Akatemia | fi |
dc.relation.funder | Suomen Akatemia | fi |
dc.relation.funder | Suomen Akatemia | fi |
dc.relation.funder | Opetus- ja kulttuuriministeriö | fi |
jyx.fundingprogram | Research costs of Academy Research Fellow, AoF | en |
jyx.fundingprogram | Academy Project, AoF | en |
jyx.fundingprogram | Academy Research Fellow, AoF | en |
jyx.fundingprogram | Others | en |
jyx.fundingprogram | Akatemiatutkijan tutkimuskulut, SA | fi |
jyx.fundingprogram | Akatemiahanke, SA | fi |
jyx.fundingprogram | Akatemiatutkija, SA | fi |
jyx.fundingprogram | Muut | fi |
jyx.fundinginformation | Supported by the Academy of Finland grants 309504, 314181, 335249 (to EKL) and 135038 (to SC) and by the Ministry of Education and Culture of Finland grants OKM/54/627/2006, OKM/77/627/2008 (to SC) and OKM/10/626/2021 (to JKI). The manuscript preparation was supported by the Academy of Finland grant 330281 (to EKL). The contents of this article are solely the responsibility of the authors. | |
datacite.isSupplementedBy.doi | 10.17011/jyx/dataset/83491 | |
datacite.isSupplementedBy | Laakkonen, Eija; Kovanen, Vuokko; Sipilä, Sarianna. (2022). <i>Data from Estrogenic Regulation of Muscle Apoptosis (ERMA) study</i>. University of Jyväskylä. <a href="https://doi.org/10.17011/jyx/dataset/83491" target="_blank">https://doi.org/10.17011/jyx/dataset/83491</a>. <a href="http://urn.fi/URN:NBN:fi:jyu-202210074820">https://urn.fi/URN:NBN:fi:jyu-202210074820</a> | |
dc.type.okm | A1 | |