Show simple item record

dc.contributor.authorOlvera‐Rojas, Marcos
dc.contributor.authorPlaza‐Florido, Abel
dc.contributor.authorSolis‐Urra, Patricio
dc.contributor.authorRodriguez‐Ayllon, María
dc.contributor.authorToval, Angel
dc.contributor.authorEsteban‐Cornejo, Irene
dc.contributor.authorOrtega, Francisco B.
dc.date.accessioned2023-10-18T09:45:12Z
dc.date.available2023-10-18T09:45:12Z
dc.date.issued2023
dc.identifier.citationOlvera‐Rojas, M., Plaza‐Florido, A., Solis‐Urra, P., Rodriguez‐Ayllon, M., Toval, A., Esteban‐Cornejo, I., & Ortega, F. B. (2023). Association of muscular strength and targeted proteomics involved in brain health in children with overweight/obesity. <i>Scandinavian Journal of Medicine and Science in Sports</i>, <i>33</i>(9), 1738-1751. <a href="https://doi.org/10.1111/sms.14387" target="_blank">https://doi.org/10.1111/sms.14387</a>
dc.identifier.otherCONVID_193480092
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/90110
dc.description.abstractMuscular strength has been positively associated with better brain health indicators during childhood obesity. However, the molecular mechanisms underlying the positive impact of muscular strength in brain health are poorly understood. We aimed to study the association of muscular strength with neurology-related circulating proteins in plasma in children with overweight/obesity and to explore the role of cardiorespiratory fitness (CRF) as a confounder. The participants were 86 Caucasian children (10.1 ± 1.1 years old; 41% girls) from the ActiveBrains project. Muscular strength was measured by field and laboratory tests. CRF was assessed with an incremental treadmill test. Olink's technology was used to quantify 92 neurology-related proteins in plasma. Protein–protein interactions were computed using the STRING website. Muscular strength was positively associated with 12 proteins (BetaNGF, CDH6, CLEC10A, CLM1, FcRL2, HAGH, IL12, LAIR2, MSR1, SCARB2, SMOC2, and TNFRSF12A), and negatively associated with 12 proteins (CLEC1B, CTSC, CTSS, gal-8, GCP5, NAAA, NrCAM, NTRK2, PLXNB3, RSPO1, sFRP3, and THY1). After adjustment for CRF, muscular strength was positively associated with eight proteins (BetaNGF, CDH6, CLEC10A, FcRL2, LAIR2, MSR1, SCARB2, and TNFRSF12A) and negatively associated with two proteins (gal-8 and NrCAM). After applying FDR correction, only CLEC10A remained statistically significant. In conclusion, muscular strength was associated with blood circulating proteins involved in several biological processes, particularly anti-inflammatory response, lipid metabolism, beta amyloid clearance, and neuronal action potential propagation. More powered studies are warranted in pediatric populations to contrast or confirm our findings.en
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherWiley
dc.relation.ispartofseriesScandinavian Journal of Medicine and Science in Sports
dc.rightsCC BY 4.0
dc.subject.otherbiomarkers
dc.subject.otherbrain health
dc.subject.othercardiorespiratory fitness
dc.subject.otherchildren
dc.subject.othermuscular strength
dc.subject.otherproteomics
dc.titleAssociation of muscular strength and targeted proteomics involved in brain health in children with overweight/obesity
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-202310186148
dc.contributor.laitosLiikuntatieteellinen tiedekuntafi
dc.contributor.laitosFaculty of Sport and Health Sciencesen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1
dc.description.reviewstatuspeerReviewed
dc.format.pagerange1738-1751
dc.relation.issn0905-7188
dc.relation.numberinseries9
dc.relation.volume33
dc.type.versionpublishedVersion
dc.rights.copyright© 2023 The Authors. Scandinavian Journal of Medicine & Science In Sports published by John Wiley & Sons Ltd.
dc.rights.accesslevelopenAccessfi
dc.subject.ysolapset (ikäryhmät)
dc.subject.ysoterveys
dc.subject.ysolihavuus
dc.subject.ysokunto
dc.subject.ysoylipaino
dc.subject.ysolihasvoima
dc.subject.ysoproteomiikka
dc.subject.ysoproteiinit
dc.subject.ysoaivot
dc.subject.ysobiomarkkerit
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p4354
jyx.subject.urihttp://www.yso.fi/onto/yso/p2762
jyx.subject.urihttp://www.yso.fi/onto/yso/p823
jyx.subject.urihttp://www.yso.fi/onto/yso/p7383
jyx.subject.urihttp://www.yso.fi/onto/yso/p826
jyx.subject.urihttp://www.yso.fi/onto/yso/p23362
jyx.subject.urihttp://www.yso.fi/onto/yso/p7548
jyx.subject.urihttp://www.yso.fi/onto/yso/p4332
jyx.subject.urihttp://www.yso.fi/onto/yso/p7040
jyx.subject.urihttp://www.yso.fi/onto/yso/p12288
dc.rights.urlhttps://creativecommons.org/licenses/by/4.0/
dc.relation.doi10.1111/sms.14387
jyx.fundinginformationThe present study was supported by grants from the Spanish Ministry of Economy and Competitiveness (DEP2013-47540, DEP2016-79512-R, and DEP2017-91544-EXP), European Regional Development Fund (ERDF) of the European Commission (Number 667302), and by the Alicia Koplowitz Foundation. Supplementary funding was obtained from the Andalusian Operational Programme supported with ERDF (FEDER in Spanish, B-CTS-355-UGR18). This study was also supported by the University of Granada, Plan Propio de Investigación, Visiting Scholar grants and Excellence actions: Units of Excellence; Unit of Excellence on Exercise, Nutrition and Health (UCEENS) and by the Junta de Andalucía, Consejería de Conocimiento, Investigación y Universidades and the ERDF (SOMM17/6107/UGR). The present study was further supported by the EXERNET Research Network on Exercise and Health (DEP2005-00046/ACTI) and by the High Council of Sports (09/UPB/19). AP-F contribution was funded in part by NIH grant #: U01TR002004 (project REACH). MR-A was supported by the Alicia Koplowitz Foundation. IE-C is supported by the Spanish Ministry of Science and Innovation (RyC2019-027287-1). PS-U is supported by a grant from ANID/BECAS Chile/72180543 and through a Margarita Salas grant from the Spanish Ministry Universities. AT is supported by the Junta de Andalucía postdoctoral research grant. Funding for open access charge: Universidad de Granada / CBUA. This work is part of Ph.D. Thesis conducted in the Biomedicine Doctoral Studies of the University of Granada, Spain.
dc.type.okmA1


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record

CC BY 4.0
Except where otherwise noted, this item's license is described as CC BY 4.0