Association of muscular strength and targeted proteomics involved in brain health in children with overweight/obesity
Olvera‐Rojas, M., Plaza‐Florido, A., Solis‐Urra, P., Rodriguez‐Ayllon, M., Toval, A., Esteban‐Cornejo, I., & Ortega, F. B. (2023). Association of muscular strength and targeted proteomics involved in brain health in children with overweight/obesity. Scandinavian Journal of Medicine and Science in Sports, 33(9), 1738-1751. https://doi.org/10.1111/sms.14387
Julkaistu sarjassa
Scandinavian Journal of Medicine and Science in SportsTekijät
Päivämäärä
2023Tekijänoikeudet
© 2023 The Authors. Scandinavian Journal of Medicine & Science In Sports published by John Wiley & Sons Ltd.
Muscular strength has been positively associated with better brain health indicators during childhood obesity. However, the molecular mechanisms underlying the positive impact of muscular strength in brain health are poorly understood. We aimed to study the association of muscular strength with neurology-related circulating proteins in plasma in children with overweight/obesity and to explore the role of cardiorespiratory fitness (CRF) as a confounder. The participants were 86 Caucasian children (10.1 ± 1.1 years old; 41% girls) from the ActiveBrains project. Muscular strength was measured by field and laboratory tests. CRF was assessed with an incremental treadmill test. Olink's technology was used to quantify 92 neurology-related proteins in plasma. Protein–protein interactions were computed using the STRING website. Muscular strength was positively associated with 12 proteins (BetaNGF, CDH6, CLEC10A, CLM1, FcRL2, HAGH, IL12, LAIR2, MSR1, SCARB2, SMOC2, and TNFRSF12A), and negatively associated with 12 proteins (CLEC1B, CTSC, CTSS, gal-8, GCP5, NAAA, NrCAM, NTRK2, PLXNB3, RSPO1, sFRP3, and THY1). After adjustment for CRF, muscular strength was positively associated with eight proteins (BetaNGF, CDH6, CLEC10A, FcRL2, LAIR2, MSR1, SCARB2, and TNFRSF12A) and negatively associated with two proteins (gal-8 and NrCAM). After applying FDR correction, only CLEC10A remained statistically significant. In conclusion, muscular strength was associated with blood circulating proteins involved in several biological processes, particularly anti-inflammatory response, lipid metabolism, beta amyloid clearance, and neuronal action potential propagation. More powered studies are warranted in pediatric populations to contrast or confirm our findings.
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WileyISSN Hae Julkaisufoorumista
0905-7188Asiasanat
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https://converis.jyu.fi/converis/portal/detail/Publication/193480092
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The present study was supported by grants from the Spanish Ministry of Economy and Competitiveness (DEP2013-47540, DEP2016-79512-R, and DEP2017-91544-EXP), European Regional Development Fund (ERDF) of the European Commission (Number 667302), and by the Alicia Koplowitz Foundation. Supplementary funding was obtained from the Andalusian Operational Programme supported with ERDF (FEDER in Spanish, B-CTS-355-UGR18). This study was also supported by the University of Granada, Plan Propio de Investigación, Visiting Scholar grants and Excellence actions: Units of Excellence; Unit of Excellence on Exercise, Nutrition and Health (UCEENS) and by the Junta de Andalucía, Consejería de Conocimiento, Investigación y Universidades and the ERDF (SOMM17/6107/UGR). The present study was further supported by the EXERNET Research Network on Exercise and Health (DEP2005-00046/ACTI) and by the High Council of Sports (09/UPB/19). AP-F contribution was funded in part by NIH grant #: U01TR002004 (project REACH). MR-A was supported by the Alicia Koplowitz Foundation. IE-C is supported by the Spanish Ministry of Science and Innovation (RyC2019-027287-1). PS-U is supported by a grant from ANID/BECAS Chile/72180543 and through a Margarita Salas grant from the Spanish Ministry Universities. AT is supported by the Junta de Andalucía postdoctoral research grant. Funding for open access charge: Universidad de Granada / CBUA. This work is part of Ph.D. Thesis conducted in the Biomedicine Doctoral Studies of the University of Granada, Spain. ...Lisenssi
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Cardiorespiratory fitness and targeted proteomics involved in brain and cardiovascular health in children with overweight/obesity
Plaza-Florido, Abel; Rodriguez-Ayllon, Maria; Altmäe, Signe; Ortega, Francisco B.; Esteban-Cornejo, Irene (Routledge, 2023)Cardiorespiratory fitness (CRF) is inversely associated with cardiovascular disease (CVD) risk factors and brain health impairments. However, the molecular mechanisms linking CRF to health in children are poorly understood. ... -
Targeted proteomics involved in cardiovascular health and heart rate variability in children with overweight/obesity
Plaza‐Florido, Abel; Olvera‐Rojas, Marcos; Alcantara, Juan M. A.; Radom‐Aizik, Shlomit; Ortega, Francisco B. (Wiley, 2024)Background Children with overweight/obesity often exhibit alterations in their plasma protein profiles and reduced heart rate variability (HRV). Plasma proteomics is at the forefront of identifying biomarkers for various ... -
Which indices of cardiorespiratory fitness are more strongly associated with brain health in children with overweight/obesity?
Haapala, Eero A.; Lubans, David R.; Jaakkola, Timo; Barker, Alan R.; Plaza‐Florido, Abel; Gracia‐Marco, Luis; Solis‐Urra, Patricio; Cadenas‐Sanchez, Cristina; Esteban‐Cornejo, Irene; Ortega, Francisco B. (Wiley-Blackwell, 2024)Purpose To compare the strength of associations between different indices of cardiorespiratory fitness (CRF) and brain health outcomes in children with overweight/obesity. Methods Participants were 100 children aged ... -
Physical activity, sedentary time, and fitness in relation to brain shapes in children with overweight/obesity : Links to intelligence
Cadenas‐Sanchez, Cristina; Migueles, Jairo H.; Verdejo‐Román, Juan; Erickson, Kirk I.; Esteban‐Cornejo, Irene; Catena, Andrés; Ortega, Francisco B. (Wiley, 2023)Objectives To examine the association between physical activity, sedentary time, and physical fitness with the shapes of subcortical brain structures in children with overweight/obesity. Further, we analyzed whether ... -
Differences in specific abdominal fat depots between metabolically healthy and unhealthy children with overweight/obesity : The role of cardiorespiratory fitness
Cadenas‐Sanchez, Cristina; Medrano, María; Villanueva, Arantxa; Cabeza, Rafael; Idoate, Fernando; Osés, Maddi; Rodríguez‐Vigil, Beatriz; Álvarez de Eulate, Natalia; Alberdi Aldasoro, Nerea; Ortega, Francisco B.; Labayen, Idoia (Wiley, 2023)Objectives Fat depots localization has a critical role in the metabolic health status of adults. Nevertheless, whether that is also the case in children remains under-studied. Therefore, the aims of this study were: (i) ...
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