Multispecies coinfections and presence of antibiotics shape resistance and fitness costs in a pathogenic bacterium
Ashrafi, R., Bruneaux, M., Sundberg, L., Hoikkala, V., & Karvonen, A. (2023). Multispecies coinfections and presence of antibiotics shape resistance and fitness costs in a pathogenic bacterium. Molecular Ecology, 32(15), 4447-4460. https://doi.org/10.1111/mec.17040
Julkaistu sarjassa
Molecular EcologyTekijät
Päivämäärä
2023Oppiaine
Akvaattiset tieteetSolu- ja molekyylibiologiaNanoscience CenterEkologia ja evoluutiobiologiaHyvinvoinnin tutkimuksen yhteisöResurssiviisausyhteisöAquatic SciencesCell and Molecular BiologyNanoscience CenterEcology and Evolutionary BiologySchool of WellbeingSchool of Resource WisdomTekijänoikeudet
© 2023 The Authors. Molecular Ecology published by John Wiley & Sons Ltd.
Increasing antimicrobial resistance (AMR) poses a challenge for treatment of bacterial diseases. In real life, bacterial infections are typically embedded within complex multispecies communities and influenced by the environment, which can shape costs and benefits of AMR. However, knowledge of such interactions and their implications for AMR in vivo is limited. To address this knowledge gap, we investigated fitness-related traits of a pathogenic bacterium (Flavobacterium columnare) in its fish host, capturing the effects of bacterial antibiotic resistance, coinfections between bacterial strains and metazoan parasites (fluke Diplostomum pseudospathaceum) and antibiotic exposure. We quantified real-time replication and virulence of sensitive and resistant bacteria and demonstrate that both bacteria can benefit from coinfection in terms of persistence and replication, depending on the coinfecting partner and antibiotic presence. We also show that antibiotics can benefit resistant bacteria by increasing bacterial replication under coinfection with flukes. These results emphasize the importance of diverse, inter-kingdom coinfection interactions and antibiotic exposure in shaping costs and benefits of AMR, supporting their role as significant contributors to spread and long-term persistence of resistance.
...
Julkaisija
Wiley-BlackwellISSN Hae Julkaisufoorumista
0962-1083Asiasanat
Julkaisu tutkimustietojärjestelmässä
https://converis.jyu.fi/converis/portal/detail/Publication/183553829
Metadata
Näytä kaikki kuvailutiedotKokoelmat
Rahoittaja(t)
Suomen AkatemiaRahoitusohjelmat(t)
Akatemiahanke, SALisätietoja rahoituksesta
Academy of Finland, Grant/Award Number: 314939 and 310632; OLVI- Säätiö, Grant/Award Number: 201620393Lisenssi
Samankaltainen aineisto
Näytetään aineistoja, joilla on samankaltainen nimeke tai asiasanat.
-
Beta-Lactam Sensitive Bacteria Can Acquire ESBL-Resistance via Conjugation after Long-Term Exposure to Lethal Antibiotic Concentration
Ruotsalainen, Pilvi; Given, Cindy; Penttinen, Reetta; Jalasvuori, Matti (MDPI, 2020)Beta-lactams are commonly used antibiotics that prevent cell-wall biosynthesis. Beta-lactam sensitive bacteria can acquire conjugative resistance elements and hence become resistant even after being exposed to lethal (above ... -
Small things matter : of phages and antibiotic resistance conferring plasmids
Mattila, Sari (University of Jyväskylä, 2016)Viruses and plasmids are small units of genetic material dependent on cells either transiently or continuously. Intriguingly, stories of these small entities intertwine in antibiotic resistance crisis. Horizontal gene ... -
Occurrence of antibiotics and risk of antibiotic resistance evolution in selected Kenyan wastewaters, surface waters and sediments
Kairigo, Pius; Ngumba, Elijah; Sundberg, Lotta-Riina; Gachanja, Anthony; Tuhkanen, Tuula (Elsevier, 2020)Active pharmaceutical ingredients, especially antibiotics, are micropollutants whose continuous flow into hydrological cycles has the potential to mediate antibiotic resistance in the environment and cause toxicity to ... -
Systematic Comparison of Epidemic and Non-Epidemic Carbapenem Resistant Klebsiella pneumoniae Strains
Koskinen, Katariina; Penttinen, Reetta; Örmälä-Odegrip, Anni-Maria; Giske, Christian G.; Ketola, Tarmo; Jalasvuori, Matti (Frontiers Media, 2021)Over the past few decades, extensively drug resistant (XDR) resistant Klebsiella pneumoniae has become a notable burden to healthcare all over the world. Especially carbapenemase-producing strains are problematic due to ... -
CRICON-plasmidisysteemin siirtyminen kliinisiin ESBL-bakteerikantoihin
Vacker, Sanna; Maja, Anni; Lintilä, Emilia (2021)Bakteerit ovat kehittäneet useita erilaisia mekanismeja, joiden avulla ne voivat suojautua antibiootteja ja muita toksisia yhdisteitä vastaan. Tähän tarkoitukseen toimiva keino on vieraan DNA:n hankinta horisontaalisen ...
Ellei toisin mainittu, julkisesti saatavilla olevia JYX-metatietoja (poislukien tiivistelmät) saa vapaasti uudelleenkäyttää CC0-lisenssillä.