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dc.contributor.authorMujunen, Toni
dc.contributor.authorNurmi, Timo
dc.contributor.authorPiitulainen, Harri
dc.date.accessioned2021-07-16T08:12:20Z
dc.date.available2021-07-16T08:12:20Z
dc.date.issued2021
dc.identifier.citationMujunen, T., Nurmi, T., & Piitulainen, H. (2021). Corticokinematic coherence is stronger to regular than irregular proprioceptive stimulation of the hand. <i>Journal of Neurophysiology</i>, <i>126</i>(2), 550-560. <a href="https://doi.org/10.1152/jn.00095.2021" target="_blank">https://doi.org/10.1152/jn.00095.2021</a>
dc.identifier.otherCONVID_99025229
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/77166
dc.description.abstractProprioceptive afference can be investigated using corticokinematic coherence (CKC), which indicates coupling between limb kinematics and cortical activity. CKC has been quantified using proprioceptive stimulation (movement actuators) with fixed inter-stimulus interval (ISI). However, it is unclear how regularity of the stimulus sequence (jitter) affects CKC strength. Eighteen healthy volunteers (16 right-handed, 27.8±5.0 yrs, 7 females) participated in magnetoencephalography (MEG) session in which their right-index finger was continuously moved at ~3-Hz with constant 333 ms ISI or with 20% jitter (ISI 333±66 ms) using a pneumatic-movement actuator. Three minutes of data per condition was collected. Finger kinematics were recorded with a 3-axis accelerometer. CKC strength was defined as the peak coherence value in the Rolandic MEG gradiometer pair contralateral to the movement at 3-Hz. Both conditions resulted in significant coherence peaking in the gradiometers over the primary sensorimotor cortex. Constant stimulation yielded stronger CKC at 3 Hz (0.78±0.11 vs. 0.66±0.13, p<0.001) and its first harmonic (0.60±0.19 vs. 0.27±0.11, p<0.001) than irregular stimulation. Similarly, the respective sustained-movement evoked field was also stronger for constant stimulation. The results emphasize the importance of temporal stability of the proprioceptive stimulation sequence when quantifying CKC strength. The weaker CKC during irregular stimulation can be explained with temporal and thus spectral scattering of the paired peripheral and cortical events beyond the mean stimulation frequency. This impairs the signal-to-noise ratio of respective MEG signal and thus CKC strength. When accurately estimating and following changes in CKC strength, we suggest using precise movement actuators with constant stimulation sequence.en
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherAmerican Physiological Society
dc.relation.ispartofseriesJournal of Neurophysiology
dc.rightsCC BY 4.0
dc.subject.othersensomotoriikka
dc.subject.otherproprioseptiikka
dc.subject.otherproprioception
dc.subject.othermovement-evoked field
dc.subject.otherkinematics
dc.subject.othersomatosensory
dc.subject.otherjitter
dc.titleCorticokinematic coherence is stronger to regular than irregular proprioceptive stimulation of the hand
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-202107164341
dc.contributor.laitosLiikuntatieteellinen tiedekuntafi
dc.contributor.laitosFaculty of Sport and Health Sciencesen
dc.contributor.oppiaineMonitieteinen aivotutkimuskeskusfi
dc.contributor.oppiaineCentre for Interdisciplinary Brain Researchen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.description.reviewstatuspeerReviewed
dc.format.pagerange550-560
dc.relation.issn0022-3077
dc.relation.numberinseries2
dc.relation.volume126
dc.type.versionacceptedVersion
dc.rights.copyright© 2021 The Authors
dc.rights.accesslevelopenAccessfi
dc.relation.grantnumber326988
dc.relation.grantnumber327288
dc.subject.ysoaivokuori
dc.subject.ysoliikeoppi
dc.subject.ysoMEG
dc.subject.ysomotoriikka
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p7039
jyx.subject.urihttp://www.yso.fi/onto/yso/p16028
jyx.subject.urihttp://www.yso.fi/onto/yso/p3329
jyx.subject.urihttp://www.yso.fi/onto/yso/p496
dc.rights.urlhttps://creativecommons.org/licenses/by/4.0/
dc.relation.doi10.1152/jn.00095.2021
dc.relation.funderSuomen Akatemiafi
dc.relation.funderSuomen Akatemiafi
dc.relation.funderAcademy of Finlanden
dc.relation.funderAcademy of Finlanden
jyx.fundingprogramAkatemiatutkijan tehtävä, SAfi
jyx.fundingprogramAkatemiatutkijan tutkimuskulut, SAfi
jyx.fundingprogramResearch post as Academy Research Fellow, AoFen
jyx.fundingprogramResearch costs of Academy Research Fellow, AoFen
jyx.fundinginformationThis study has been supported by the Academy of Finland ”Brain changes across the life-span” profiling funding to University of Jyväskylä. HP was supported by Academy of Finland (grants #296240, #326988, #307250 and #327288) to HP and Jane and Aatos Erkko Foundation


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