Cortical networks show characteristic recruitment patterns after somatosensory stimulation by pneumatically evoked repetitive hand movements in newborn infants
Ahtola, E., Leikos, S., Tuiskula, A., Haataja, L., Smeds, E., Piitulainen, H., Jousmäki, V., Tokariev, A., & Vanhatalo, S. (2023). Cortical networks show characteristic recruitment patterns after somatosensory stimulation by pneumatically evoked repetitive hand movements in newborn infants. Cerebral Cortex, 33(8), Article 4699-4713. https://doi.org/10.1093/cercor/bhac373
Julkaistu sarjassa
Cerebral CortexTekijät
Päivämäärä
2023Tekijänoikeudet
© The Author(s) 2022. Published by Oxford University Press.
Controlled assessment of functional cortical networks is an unmet need in the clinical research of noncooperative subjects, such as infants. We developed an automated, pneumatic stimulation method to actuate naturalistic movements of an infant’s hand, as well as an analysis pipeline for assessing the elicited electroencephalography (EEG) responses and related cortical networks. Twenty newborn infants with perinatal asphyxia were recruited, including 7 with mild-to-moderate hypoxic–ischemic encephalopathy (HIE). Statistically significant corticokinematic coherence (CKC) was observed between repetitive hand movements and EEG in all infants, peaking near the contralateral sensorimotor cortex. CKC was robust to common sources of recording artifacts and to changes in vigilance state. A wide recruitment of cortical networks was observed with directed phase transfer entropy, also including areas ipsilateral to the stimulation. The extent of such recruited cortical networks was quantified using a novel metric, Spreading Index, which showed a decrease in 4 (57%) of the infants with HIE. CKC measurement is noninvasive and easy to perform, even in noncooperative subjects. The stimulation and analysis pipeline can be fully automated, including the statistical evaluation of the cortical responses. Therefore, the CKC paradigm holds great promise as a scientific and clinical tool for controlled assessment of functional cortical networks.
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Oxford University Press (OUP)ISSN Hae Julkaisufoorumista
1047-3211Asiasanat
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https://converis.jyu.fi/converis/portal/detail/Publication/164382259
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- Liikuntatieteiden tiedekunta [2919]
Rahoittaja(t)
Suomen AkatemiaRahoitusohjelmat(t)
Akatemiatutkija, SA; Profilointi, SALisätietoja rahoituksesta
This work was supported by Finnish Pediatric Foundation; the Finnish Academy (grants #332017 to SV, #335778 to SV, #321235 to AT, #296240 to HP, and #326988 to HP); Juselius Foundation; Finnish Brain Foundation; Jane and Aatos Erkko Foundation; “Brain changes across the life-span” profiling funding to University of Jyväskylä (grant #311877 to HP); and Helsinki University Central Hospital.Lisenssi
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