More comprehensive proprioceptive stimulation of the hand amplifies its cortical processing
Hakonen, M., Nurmi, T., Vallinoja, J., Jaatela, J., & Piitulainen, H. (2022). More comprehensive proprioceptive stimulation of the hand amplifies its cortical processing. Journal of neurophysiology, 128(3), 568-581. https://doi.org/10.1152/jn.00485.2021
Published inJournal of neurophysiology
© 2022 The Authors
Corticokinematic coherence (CKC) quantifies the phase coupling between limb kinematics and cortical neurophysiological signals reflecting proprioceptive feedback to the primary sensorimotor (SM1) cortex. We studied whether the CKC strength or cortical source location differs between proprioceptive stimulation (i.e., actuator-evoked movements) of right-hand digits (index, middle, ring and little). Twenty-one volunteers participated in magnetoencephalography measurements during which three conditions were tested: (1) simultaneous stimulation of all four fingers at the same frequency, (2) stimulation of each finger separately at the same frequency and (3) simultaneous stimulation of the fingers at finger-specific frequencies. CKC was computed between MEG responses and accelerations of the fingers recorded with three-axis accelerometers. CKC was stronger (p < 0.003) for the simultaneous (0.52 ± 0.02) than separate (0.45 ± 0.02) stimulation at the same frequency. Furthermore, CKC was weaker (p < 0.03) for the simultaneous stimulation at the finger-specific frequencies (0.38 ± 0.02) than for the separate stimulation. CKC source locations of the fingers were concentrated in the hand region of the SM1 cortex and did not follow consistent finger-specific somatotopic order. Our results indicate that that proprioceptive afference from the fingers is processed in partly overlapping cortical neuronal circuits, which was demonstrated by the modulation of the finger specific CKC strengths due to proprioceptive afference arising from simultaneous stimulation of the other fingers of the same hand as well as overlapping cortical source locations. Finally, comprehensive simultaneous proprioceptive stimulation of the hand would optimize functional cortical mapping to pinpoint the hand region, e.g., prior brain surgery. ...
PublisherAmerican Physiological Society
Publication in research information system
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- Liikuntatieteiden tiedekunta 
Related funder(s)Academy of Finland
Funding program(s)Research profiles, AoF; Research costs of Academy Research Fellow, AoF; Academy Research Fellow, AoF
Additional information about fundingThis study has been supported by the Academy of Finland (grants #296240, #326988, #307250 and #327288, HP), Jane and Aatos Erkko Foundation (HP), ”Brain changes across the life-span” profiling funding (#311877, University of Jyväskylä), Finnish Cultural Foundation (MH) and Paulo Foundation (MH).
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