Altered excitation-inhibition balance in the primary sensorimotor cortex to proprioceptive hand stimulation in cerebral palsy
Illman, M., Jaatela, J., Vallinoja, J., Nurmi, T., Mäenpää, H., & Piitulainen, H. (2024). Altered excitation-inhibition balance in the primary sensorimotor cortex to proprioceptive hand stimulation in cerebral palsy. Clinical Neurophysiology, 157, 25-36. https://doi.org/10.1016/j.clinph.2023.10.016
Published in
Clinical NeurophysiologyAuthors
Date
2024Copyright
© 2023 International Federation of Clinical Neurophysiology
Objective
Our objective was to clarify the primary sensorimotor (SM1) cortex excitatory and inhibitory alterations in hemiplegic (HP) and diplegic (DP) cerebral palsy (CP) by quantifying SM1 cortex beta power suppression and rebound with magnetoencephalography (MEG).
Methods
MEG was recorded from 16 HP and 12 DP adolescents, and their 32 healthy controls during proprioceptive stimulation of the index fingers evoked by a movement actuator. The related beta power changes were computed with Temporal Spectral Evolution (TSE). Peak strengths of beta suppression and rebound were determined from representative channels over the SM1 cortex.
Results
Beta suppression was stronger contralateral to the stimulus and rebound was weaker ipsilateral to the stimulation in DP compared to controls. Beta modulation strengths did not differ significantly between HP and the control group.
Conclusions
The emphasized beta suppression in DP suggests less efficient proprioceptive processing in the SM1 contralateral to the stimulation. Their weak rebound further indicates reduced intra- and/or interhemispheric cortical inhibition, which is a potential neuronal mechanism for their bilateral motor impairments.
Significance
The excitation-inhibition balance of the SM1 cortex related to proprioception is impaired in diplegic CP. Therefore, the cortical and behavioral proprioceptive deficits should be better diagnosed and considered to better target individualized effective rehabilitation in CP.
...
Publisher
ElsevierISSN Search the Publication Forum
1388-2457Keywords
Publication in research information system
https://converis.jyu.fi/converis/portal/detail/Publication/194834171
Metadata
Show full item recordCollections
- Liikuntatieteiden tiedekunta [3092]
Related funder(s)
Research Council of FinlandFunding program(s)
Academy Research Fellow, AoF; Research costs of Academy Research Fellow, AoFAdditional information about funding
This work was supported by the Academy of Finland [grants #296240, #326988, #307250, and #327288] and the Jane and Aatos Erkko Foundation to Harri Piitulainen.License
Related items
Showing items with similar title or keywords.
-
Reproducibility of evoked and induced MEG responses to proprioceptive stimulation of the ankle joint
Mujunen, Toni; Seipäjärvi, Santtu; Nurminen, Mila; Parviainen, Tiina; Piitulainen, Harri (Elsevier, 2022)Cortical processing of proprioceptive afference can be investigated by examining phase locked evoked and induced responses in cortical signals to passive movement stimuli. Reproducibility of evoked and induced responses ... -
Cortical Proprioceptive Processing Is Altered by Aging
Piitulainen, Harri; Seipäjärvi, Santtu; Avela, Janne; Parviainen, Tiina; Walker, Simon (Frontiers Research Foundation, 2018)Proprioceptive perception is impaired with aging, but little is known about aging-related deterioration of proprioception at the cortical level. Corticokinematic coherence (CKC) between limb kinematic and magnetoencephalographic ... -
The effect of alertness and attention on the modulation of the beta rhythm to tactile stimulation
Illman, Mia; Laaksonen, Kristina; Liljeström, Mia; Piitulainen, Harri; Forss, Nina (John Wiley & Sons, 2021)Beta rhythm modulation has been used as a biomarker to reflect the functional state of the sensorimotor cortex in both healthy subjects and patients. Here, the effect of reduced alertness and active attention to the stimulus ... -
Older Age Increases the Amplitude of Muscle Stretch-Induced Cortical Beta-Band Suppression But Does not Affect Rebound Strength
Walker, Simon; Monto, Simo; Piirainen, Jarmo M.; Avela, Janne; Tarkka, Ina M.; Parviainen, Tiina M.; Piitulainen, Harri (Frontiers Media, 2020)Healthy aging is associated with deterioration of the sensorimotor system, which impairs balance and somatosensation. However, the exact age-related changes in the cortical processing of sensorimotor integration are unclear. ... -
Comparing MEG and EEG in detecting the ~20-Hz rhythm modulation to tactile and proprioceptive stimulation
Illman, Mia; Laaksonen, Kristina; Liljeström, Mia; Jousmäki, Veikko; Piitulainen, Harri; Fross, Nina (Elsevier, 2020)Modulation of the ~20-Hz brain rhythm has been used to evaluate the functional state of the sensorimotor cortex both in healthy subjects and patients, such as stroke patients. The ~20-Hz brain rhythm can be detected by ...