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dc.contributor.authorHintikka, Jukka
dc.contributor.authorLensu, Sanna
dc.contributor.authorMäkinen, Elina
dc.contributor.authorKarvinen, Sira
dc.contributor.authorHonkanen, Marjaana
dc.contributor.authorLindén, Jere
dc.contributor.authorGarrels, Tim
dc.contributor.authorPekkala, Satu
dc.contributor.authorLahti, Leo
dc.date.accessioned2021-04-16T08:57:57Z
dc.date.available2021-04-16T08:57:57Z
dc.date.issued2021
dc.identifier.citationHintikka, J., Lensu, S., Mäkinen, E., Karvinen, S., Honkanen, M., Lindén, J., Garrels, T., Pekkala, S., & Lahti, L. (2021). Xylo-Oligosaccharides in Prevention of Hepatic Steatosis and Adipose Tissue Inflammation : Associating Taxonomic and Metabolomic Patterns in Fecal Microbiomes with Biclustering. <i>International Journal of Environmental Research and Public Health</i>, <i>18</i>(8), Article 4049. <a href="https://doi.org/10.3390/ijerph18084049" target="_blank">https://doi.org/10.3390/ijerph18084049</a>
dc.identifier.otherCONVID_66397002
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/75085
dc.description.abstractWe have shown that prebiotic xylo-oligosaccharides (XOS) increased beneficial gut microbiota (GM) and prevented high fat diet-induced hepatic steatosis, but the mechanisms associated with these effects are not clear. We studied whether XOS affects adipose tissue inflammation and insulin signaling, and whether the GM and fecal metabolome explain associated patterns. XOS was supplemented or not with high (HFD) or low (LFD) fat diet for 12 weeks in male Wistar rats (n = 10/group). Previously analyzed GM and fecal metabolites were biclustered to reduce data dimensionality and identify interpretable groups of co-occurring genera and metabolites. Based on our findings, biclustering provides a useful algorithmic method for capturing such joint signatures. On the HFD, XOS-supplemented rats showed lower number of adipose tissue crown-like structures, increased phosphorylation of AKT in liver and adipose tissue as well as lower expression of hepatic miRNAs. XOS-supplemented rats had more fecal glycine and less hypoxanthine, isovalerate, branched chain amino acids and aromatic amino acids. Several bacterial genera were associated with the metabolic signatures. In conclusion, the beneficial effects of XOS on hepatic steatosis involved decreased adipose tissue inflammation and likely improved insulin signaling, which were further associated with fecal metabolites and GM.en
dc.format.mimetypeapplication/pdf
dc.languageeng
dc.language.isoeng
dc.publisherMDPI AG
dc.relation.ispartofseriesInternational Journal of Environmental Research and Public Health
dc.rightsCC BY 4.0
dc.subject.othernon-alcoholic fatty liver disease
dc.subject.otherxylo-oligosaccharides
dc.subject.othermetabolites
dc.subject.othergut microbiota
dc.subject.otherbiclustering
dc.subject.otherhigh fat diet
dc.subject.othermicroRNA
dc.subject.otherrats
dc.titleXylo-Oligosaccharides in Prevention of Hepatic Steatosis and Adipose Tissue Inflammation : Associating Taxonomic and Metabolomic Patterns in Fecal Microbiomes with Biclustering
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-202104162392
dc.contributor.laitosLiikuntatieteellinen tiedekuntafi
dc.contributor.laitosPsykologian laitosfi
dc.contributor.laitosFaculty of Sport and Health Sciencesen
dc.contributor.laitosDepartment of Psychologyen
dc.contributor.oppiaineLiikuntafysiologiafi
dc.contributor.oppiaineLiikuntalääketiedefi
dc.contributor.oppiaineExercise Physiologyen
dc.contributor.oppiaineSports and Exercise Medicineen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.description.reviewstatuspeerReviewed
dc.relation.issn1661-7827
dc.relation.numberinseries8
dc.relation.volume18
dc.type.versionpublishedVersion
dc.rights.copyright© 2021 by the authors. Licensee MDPI, Basel, Switzerland
dc.rights.accesslevelopenAccessfi
dc.relation.grantnumber308042
dc.subject.ysosuolistomikrobisto
dc.subject.ysorotta (laji)
dc.subject.ysoksylo-oligosakkaridit
dc.subject.ysoprebiootit
dc.subject.ysomikro-RNA
dc.subject.ysoei-alkoholiperäinen rasvamaksasairaus
dc.subject.ysokoe-eläinmallit
dc.subject.ysoaineenvaihduntatuotteet
dc.subject.ysoaineenvaihdunta
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p37925
jyx.subject.urihttp://www.yso.fi/onto/yso/p25843
jyx.subject.urihttp://www.yso.fi/onto/yso/p23035
jyx.subject.urihttp://www.yso.fi/onto/yso/p24181
jyx.subject.urihttp://www.yso.fi/onto/yso/p27218
jyx.subject.urihttp://www.yso.fi/onto/yso/p38728
jyx.subject.urihttp://www.yso.fi/onto/yso/p28104
jyx.subject.urihttp://www.yso.fi/onto/yso/p24583
jyx.subject.urihttp://www.yso.fi/onto/yso/p3066
dc.rights.urlhttps://creativecommons.org/licenses/by/4.0/
dc.relation.doi10.3390/ijerph18084049
dc.relation.funderSuomen Akatemiafi
dc.relation.funderAcademy of Finlanden
jyx.fundingprogramAkatemiatutkijan tehtävä, SAfi
jyx.fundingprogramResearch post as Academy Research Fellow, AoFen
jyx.fundinginformationThis study was financially supported by the Academy of Finland Researcher fellowship for S.P. (grant ID 308042) and by the ERVA funding of The Hospital District of Southwest Finland for S.P. L.L. was funded by Academy of Finland Researcher fellowship (grant ID 295741). The foundation of Jenny and Antti Wihuri and the Central Finland Regional fund of the Finnish Cultural Foundation are acknowledged for their personal grants to S.L. to perform this study.


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