Xylo-Oligosaccharides in Prevention of Hepatic Steatosis and Adipose Tissue Inflammation : Associating Taxonomic and Metabolomic Patterns in Fecal Microbiomes with Biclustering
Hintikka, J., Lensu, S., Mäkinen, E., Karvinen, S., Honkanen, M., Lindén, J., Garrels, T., Pekkala, S., & Lahti, L. (2021). Xylo-Oligosaccharides in Prevention of Hepatic Steatosis and Adipose Tissue Inflammation : Associating Taxonomic and Metabolomic Patterns in Fecal Microbiomes with Biclustering. International Journal of Environmental Research and Public Health, 18(8). https://doi.org/10.3390/ijerph18084049
© 2021 by the authors. Licensee MDPI, Basel, Switzerland
We have shown that prebiotic xylo-oligosaccharides (XOS) increased beneficial gut microbiota (GM) and prevented high fat diet-induced hepatic steatosis, but the mechanisms associated with these effects are not clear. We studied whether XOS affects adipose tissue inflammation and insulin signaling, and whether the GM and fecal metabolome explain associated patterns. XOS was supplemented or not with high (HFD) or low (LFD) fat diet for 12 weeks in male Wistar rats (n = 10/group). Previously analyzed GM and fecal metabolites were biclustered to reduce data dimensionality and identify interpretable groups of co-occurring genera and metabolites. Based on our findings, biclustering provides a useful algorithmic method for capturing such joint signatures. On the HFD, XOS-supplemented rats showed lower number of adipose tissue crown-like structures, increased phosphorylation of AKT in liver and adipose tissue as well as lower expression of hepatic miRNAs. XOS-supplemented rats had more fecal glycine and less hypoxanthine, isovalerate, branched chain amino acids and aromatic amino acids. Several bacterial genera were associated with the metabolic signatures. In conclusion, the beneficial effects of XOS on hepatic steatosis involved decreased adipose tissue inflammation and likely improved insulin signaling, which were further associated with fecal metabolites and GM. ...
Publication in research information system
MetadataShow full item record
Related funder(s)Academy of Finland
Funding program(s)Research post as Academy Research Fellow, AoF
Additional information about fundingThis study was financially supported by the Academy of Finland Researcher fellowship for S.P. (grant ID 308042) and by the ERVA funding of The Hospital District of Southwest Finland for S.P. L.L. was funded by Academy of Finland Researcher fellowship (grant ID 295741). The foundation of Jenny and Antti Wihuri and the Central Finland Regional fund of the Finnish Cultural Foundation are acknowledged for their personal grants to S.L. to perform this study. ...
Showing items with similar title or keywords.
Interactive effects of aging and aerobic capacity on energy metabolism–related metabolites of serum, skeletal muscle, and white adipose tissue Zhuang, Haihui; Karvinen, Sira; Törmäkangas, Timo; Zhang, Xiaobo; Ojanen, Xiaowei; Velagapudi, Vidya; Alen, Markku; Britton, Steven L.; Koch, Lauren G.; Kainulainen, Heikki; Cheng, Sulin; Wiklund, Petri (Springer, 2021)Aerobic capacity is a strong predictor of longevity. With aging, aerobic capacity decreases concomitantly with changes in whole body metabolism leading to increased disease risk. To address the role of aerobic capacity, ...
Irradiation of the head reduces adult hippocampal neurogenesis and impairs spatial memory, but leaves overall health intact in rats Lensu, Sanna; Waselius, Tomi; Mäkinen, Elina; Kettunen, Heikki; Virtanen, Ari; Tiirola, Marja; Penttonen, Markku; Pekkala, Satu; Nokia, Miriam S. (Wiley-Blackwell, 2021)Treatment of brain cancer, glioma, can cause cognitive impairment as a side‐effect, possibly because it disrupts the integrity of the hippocampus, a structure vital for normal memory. Radiotherapy is commonly used to treat ...
Low-level environmental metal pollution is associated with altered gut microbiota of a wild rodent, the bank vole (Myodes glareolus) Brila, Ilze; Lavrinienko, Anton; Tukalenko, Eugene; Ecke, Frauke; Rodushkin, Ilia; Kallio, Eva R.; Mappes, Tapio; Watts, Phillip C. (Elsevier BV, 2021)Mining and related industries are a major source of metal pollution. In contrast to the well-studied effects of exposure to metals on animal physiology and health, the impacts of environmental metal pollution on the gut ...
Lensu, Sanna; Pekkala, Satu (MDPI AG, 2021)Trillions of microbes inhabiting the gut modulate the metabolism of the host. Cross-sectional studies have reported associations between physical performance and the gut microbiota (GM). Physical activity seems to increase ...
Lensu, Sanna; Pariyani, Raghunath; Mäkinen, Elina; Yang, Baoru; Saleem, Wisam; Munukka, Eveliina; Lehti, Maarit; Driuchina, Anastasiia; Lindén, Jere; Tiirola, Marja; Lahti, Leo; Pekkala, Satu (MDPI AG, 2020)Understanding the importance of the gut microbiota (GM) in non-alcoholic fatty liver disease (NAFLD) has raised the hope for therapeutic microbes. We have shown that high hepatic fat content associated with low abundance ...