Interactive effects of aging and aerobic capacity on energy metabolism–related metabolites of serum, skeletal muscle, and white adipose tissue
Zhuang, H., Karvinen, S., Törmäkangas, T., Zhang, X., Ojanen, X., Velagapudi, V., Alen, M., Britton, S. L., Koch, L. G., Kainulainen, H., Cheng, S., & Wiklund, P. (2021). Interactive effects of aging and aerobic capacity on energy metabolism–related metabolites of serum, skeletal muscle, and white adipose tissue. GeroScience, 43(6), 2679-2691. https://doi.org/10.1007/s11357-021-00387-1
© 2021 the Authors
Aerobic capacity is a strong predictor of longevity. With aging, aerobic capacity decreases concomitantly with changes in whole body metabolism leading to increased disease risk. To address the role of aerobic capacity, aging, and their interaction on metabolism, we utilized rat models selectively bred for low and high intrinsic aerobic capacity (LCRs/HCRs) and compared the metabolomics of serum, muscle, and white adipose tissue (WAT) at two time points: Young rats were sacrificed at 9 months of age, and old rats were sacrificed at 21 months of age. Targeted and semi-quantitative metabolomics analysis was performed on the ultra-pressure liquid chromatography tandem mass spectrometry (UPLC-MS) platform. The effects of aerobic capacity, aging, and their interaction were studied via regression analysis. Our results showed that high aerobic capacity is associated with an accumulation of isovalerylcarnitine in muscle and serum at rest, which is likely due to more efficient leucine catabolism in muscle. With aging, several amino acids were downregulated in muscle, indicating more efficient amino acid metabolism, whereas in WAT less efficient amino acid metabolism and decreased mitochondrial β-oxidation were observed. Our results further revealed that high aerobic capacity and aging interactively affect lipid metabolism in muscle and WAT, possibly combating unfavorable aging-related changes in whole body metabolism. Our results highlight the significant role of WAT metabolism for healthy aging. ...
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- Liikuntatieteiden tiedekunta 
Related funder(s)Academy of Finland
Funding program(s)Academy Project, AoF
Additional information about fundingOpen access funding provided by University of Jyväskylä (JYU). This study was funded by the Academy of Finland (grant no. 298875 to HK), Biocenter Finland, and HILIFE (VV). Finnish Government Scholarship Pool - academic year 2019/2020 (ZH), EVO research grants (years 2014/2015) from Oulu University Hospital (MA), Shanghai Jiao Tong University 111 Project (B17029, SC), Shanghai Jiao Tong University Zhiyuan Foundation (grant CP2014013, SC), and China Postdoc Scholarship Council (201806230001, XO). The LCR and HCR rat models are funded by the Office of Infrastructure Programs grant P40ODO21331 (to L.G.K and S.L.B) from the National Institutes of Health. These rat models for low and high intrinsic exercise capacity are maintained as an international resource with support from the Department of Physiology & Pharmacology, The University of Toledo College of Medicine, Toledo, OH. Contact L.G.K Lauren.Koch2@UToledo.edu or S.L.B firstname.lastname@example.org for information on the rat models. ...
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