A randomized controlled trial for response of microbiome network to exercise and diet intervention in patients with nonalcoholic fatty liver disease
Cheng, R., Wang, L., Le, S., Yang, Y., Zhao, C., Zhang, X., Yang, X., Xu, T., Xu, L., Wiklund, P., Ge, J., Lu, D., Zhang, C., Chen, L., & Cheng, S. (2022). A randomized controlled trial for response of microbiome network to exercise and diet intervention in patients with nonalcoholic fatty liver disease. Nature Communications, 13, Article 2555. https://doi.org/10.1038/s41467-022-29968-0
Published inNature Communications
Wang, Lu |
Xu, Ting |
Ge, Jun |
© The Author(s) 2022
Exercise and diet are treatments for nonalcoholic fatty liver disease (NAFLD) and prediabetes, however, how exercise and diet interventions impact gut microbiota in patients is incompletely understood. We previously reported a 8.6-month, four-arm (Aerobic exercise, n = 29; Diet, n = 28; Aerobic exercise + Diet, n = 29; No intervention, n = 29) randomized, singe blinded (for researchers), and controlled intervention in patients with NAFLD and prediabetes to assess the effect of interventions on the primary outcomes of liver fat content and glucose metabolism. Here we report the third primary outcome of the trial—gut microbiota composition—in participants who completed the trial (22 in Aerobic exercise, 22 in Diet, 23 in Aerobic exercise + Diet, 18 in No Intervention). We show that combined aerobic exercise and diet intervention are associated with diversified and stabilized keystone taxa, while exercise and diet interventions alone increase network connectivity and robustness between taxa. No adverse effects were observed with the interventions. In addition, in exploratory ad-hoc analyses we find that not all subjects responded to the intervention in a similar manner, when using differentially altered gut microbe amplicon sequence variants abundance to classify the responders and low/non-responders. A personalized gut microbial network at baseline could predict the individual responses in liver fat to exercise intervention. Our findings suggest an avenue for developing personalized intervention strategies for treatment of NAFLD based on host-gut microbiome ecosystem interactions, however, future studies with large sample size are needed to validate these discoveries. The Trial Registration Number is ISRCTN 42622771. ...
PublisherNature Publishing Group
ISSN Search the Publication Forum2041-1723
Dataset(s) related to the publicationhttps://www.ncbi.nlm.nih.gov/bioproject/?term=PRJNA757939
Publication in research information system
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Additional information about fundingFunding to S.C. was provided by the China State Sport General Administration (2013B040, 2015B039), the National Natural Science Foundation of China (Nos. 31571219), the Shanghai Jiao Tong University Zhiyuan Foundation (CP2014013), and to S.L. the Interdisciplinary Program of Shanghai Jiao Tong University (ZH2018QNB05). Funding to L.C. was supported by the National Key R&D Program of China (No. 2017YFA0505500), Strategic Priority Research Program of the Chinese Academy of Sciences (No. XDB38040400), National Natural Science Foundation of China (Nos. 31930022, 31771476, 12026608). Funding to C.Z. was supported by the National Natural Science Foundation of China (Nos. 31930022 and 81871091). ...
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