dc.contributor.author | Penttinen, Reetta | |
dc.contributor.author | Given, Cindy | |
dc.contributor.author | Jalasvuori, Matti | |
dc.date.accessioned | 2021-02-04T09:04:35Z | |
dc.date.available | 2021-02-04T09:04:35Z | |
dc.date.issued | 2021 | |
dc.identifier.citation | Penttinen, R., Given, C., & Jalasvuori, M. (2021). Indirect Selection against Antibiotic Resistance via Specialized Plasmid-Dependent Bacteriophages. <i>Microorganisms</i>, <i>9</i>(2), Article 280. <a href="https://doi.org/10.3390/microorganisms9020280" target="_blank">https://doi.org/10.3390/microorganisms9020280</a> | |
dc.identifier.other | CONVID_51309086 | |
dc.identifier.uri | https://jyx.jyu.fi/handle/123456789/73977 | |
dc.description.abstract | Antibiotic resistance genes of important Gram-negative bacterial pathogens are residing in mobile genetic elements such as conjugative plasmids. These elements rapidly disperse between cells when antibiotics are present and hence our continuous use of antimicrobials selects for elements that often harbor multiple resistance genes. Plasmid-dependent (or male-specific or, in some cases, pilus-dependent) bacteriophages are bacterial viruses that infect specifically bacteria that carry certain plasmids. The introduction of these specialized phages into a plasmid-abundant bacterial community has many beneficial effects from an anthropocentric viewpoint: the majority of the plasmids are lost while the remaining plasmids acquire mutations that make them untransferable between pathogens. Recently, bacteriophage-based therapies have become a more acceptable choice to treat multi-resistant bacterial infections. Accordingly, there is a possibility to utilize these specialized phages, which are not dependent on any particular pathogenic species or strain but rather on the resistance-providing elements, in order to improve or enlengthen the lifespan of conventional antibiotic approaches. Here, we take a snapshot of the current knowledge of plasmid-dependent bacteriophages. | en |
dc.format.mimetype | application/pdf | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | MDPI AG | |
dc.relation.ispartofseries | Microorganisms | |
dc.rights | CC BY 4.0 | |
dc.subject.other | antibiotic resistance | |
dc.subject.other | conjugative plasmids | |
dc.subject.other | plasmid-dependent | |
dc.subject.other | male-specific | |
dc.subject.other | pilus-binding | |
dc.subject.other | bacteriophages | |
dc.title | Indirect Selection against Antibiotic Resistance via Specialized Plasmid-Dependent Bacteriophages | |
dc.type | article | |
dc.identifier.urn | URN:NBN:fi:jyu-202102041424 | |
dc.contributor.laitos | Bio- ja ympäristötieteiden laitos | fi |
dc.contributor.laitos | Department of Biological and Environmental Science | en |
dc.contributor.oppiaine | Ekologia ja evoluutiobiologia | fi |
dc.contributor.oppiaine | Biologisten vuorovaikutusten huippututkimusyksikkö | fi |
dc.contributor.oppiaine | Solu- ja molekyylibiologia | fi |
dc.contributor.oppiaine | Ecology and Evolutionary Biology | en |
dc.contributor.oppiaine | Centre of Excellence in Biological Interactions Research | en |
dc.contributor.oppiaine | Cell and Molecular Biology | en |
dc.type.uri | http://purl.org/eprint/type/JournalArticle | |
dc.type.coar | http://purl.org/coar/resource_type/c_2df8fbb1 | |
dc.description.reviewstatus | peerReviewed | |
dc.relation.issn | 2076-2607 | |
dc.relation.numberinseries | 2 | |
dc.relation.volume | 9 | |
dc.type.version | publishedVersion | |
dc.rights.copyright | © 2021 by the authors. Licensee MDPI, Basel, Switzerland | |
dc.rights.accesslevel | openAccess | fi |
dc.relation.grantnumber | 297049 | |
dc.relation.grantnumber | 336518 | |
dc.subject.yso | antibioottiresistenssi | |
dc.subject.yso | bakteriofagit | |
dc.subject.yso | plasmidit | |
dc.format.content | fulltext | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p29640 | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p25303 | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p27720 | |
dc.rights.url | https://creativecommons.org/licenses/by/4.0/ | |
dc.relation.doi | 10.3390/microorganisms9020280 | |
dc.relation.funder | Research Council of Finland | en |
dc.relation.funder | Research Council of Finland | en |
dc.relation.funder | Suomen Akatemia | fi |
dc.relation.funder | Suomen Akatemia | fi |
jyx.fundingprogram | Academy Research Fellow, AoF | en |
jyx.fundingprogram | Others, AoF | en |
jyx.fundingprogram | Akatemiatutkija, SA | fi |
jyx.fundingprogram | Muut, SA | fi |
jyx.fundinginformation | This research was funded by Academy of Finland grants no. 336518, 297049 (for M.J.) and no. 322204 (for R.P.) and Jane and Aatos Erkko Foundation. | |
dc.type.okm | A1 | |