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dc.contributor.authorPenttinen, Reetta
dc.contributor.authorGiven, Cindy
dc.contributor.authorJalasvuori, Matti
dc.date.accessioned2021-02-04T09:04:35Z
dc.date.available2021-02-04T09:04:35Z
dc.date.issued2021
dc.identifier.citationPenttinen, R., Given, C., & Jalasvuori, M. (2021). Indirect Selection against Antibiotic Resistance via Specialized Plasmid-Dependent Bacteriophages. <i>Microorganisms</i>, <i>9</i>(2), Article 280. <a href="https://doi.org/10.3390/microorganisms9020280" target="_blank">https://doi.org/10.3390/microorganisms9020280</a>
dc.identifier.otherCONVID_51309086
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/73977
dc.description.abstractAntibiotic resistance genes of important Gram-negative bacterial pathogens are residing in mobile genetic elements such as conjugative plasmids. These elements rapidly disperse between cells when antibiotics are present and hence our continuous use of antimicrobials selects for elements that often harbor multiple resistance genes. Plasmid-dependent (or male-specific or, in some cases, pilus-dependent) bacteriophages are bacterial viruses that infect specifically bacteria that carry certain plasmids. The introduction of these specialized phages into a plasmid-abundant bacterial community has many beneficial effects from an anthropocentric viewpoint: the majority of the plasmids are lost while the remaining plasmids acquire mutations that make them untransferable between pathogens. Recently, bacteriophage-based therapies have become a more acceptable choice to treat multi-resistant bacterial infections. Accordingly, there is a possibility to utilize these specialized phages, which are not dependent on any particular pathogenic species or strain but rather on the resistance-providing elements, in order to improve or enlengthen the lifespan of conventional antibiotic approaches. Here, we take a snapshot of the current knowledge of plasmid-dependent bacteriophages.en
dc.format.mimetypeapplication/pdf
dc.languageeng
dc.language.isoeng
dc.publisherMDPI AG
dc.relation.ispartofseriesMicroorganisms
dc.rightsCC BY 4.0
dc.subject.otherantibiotic resistance
dc.subject.otherconjugative plasmids
dc.subject.otherplasmid-dependent
dc.subject.othermale-specific
dc.subject.otherpilus-binding
dc.subject.otherbacteriophages
dc.titleIndirect Selection against Antibiotic Resistance via Specialized Plasmid-Dependent Bacteriophages
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-202102041424
dc.contributor.laitosBio- ja ympäristötieteiden laitosfi
dc.contributor.laitosDepartment of Biological and Environmental Scienceen
dc.contributor.oppiaineEkologia ja evoluutiobiologiafi
dc.contributor.oppiaineBiologisten vuorovaikutusten huippututkimusyksikköfi
dc.contributor.oppiaineSolu- ja molekyylibiologiafi
dc.contributor.oppiaineEcology and Evolutionary Biologyen
dc.contributor.oppiaineCentre of Excellence in Biological Interactions Researchen
dc.contributor.oppiaineCell and Molecular Biologyen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1
dc.description.reviewstatuspeerReviewed
dc.relation.issn2076-2607
dc.relation.numberinseries2
dc.relation.volume9
dc.type.versionpublishedVersion
dc.rights.copyright© 2021 by the authors. Licensee MDPI, Basel, Switzerland
dc.rights.accesslevelopenAccessfi
dc.relation.grantnumber297049
dc.relation.grantnumber336518
dc.subject.ysoantibioottiresistenssi
dc.subject.ysobakteriofagit
dc.subject.ysoplasmidit
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p29640
jyx.subject.urihttp://www.yso.fi/onto/yso/p25303
jyx.subject.urihttp://www.yso.fi/onto/yso/p27720
dc.rights.urlhttps://creativecommons.org/licenses/by/4.0/
dc.relation.doi10.3390/microorganisms9020280
dc.relation.funderResearch Council of Finlanden
dc.relation.funderResearch Council of Finlanden
dc.relation.funderSuomen Akatemiafi
dc.relation.funderSuomen Akatemiafi
jyx.fundingprogramAcademy Research Fellow, AoFen
jyx.fundingprogramOthers, AoFen
jyx.fundingprogramAkatemiatutkija, SAfi
jyx.fundingprogramMuut, SAfi
jyx.fundinginformationThis research was funded by Academy of Finland grants no. 336518, 297049 (for M.J.) and no. 322204 (for R.P.) and Jane and Aatos Erkko Foundation.
dc.type.okmA1


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