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Fight evolution with evolution: plasmid-dependent phages with a wide host range prevent the spread of antibiotic resistances

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Ojala, V., Laitalainen, J., & Jalasvuori, M. (2013). Fight evolution with evolution: plasmid-dependent phages with a wide host range prevent the spread of antibiotic resistances. Evolutionary Applications, 6(6), 925–932. https://doi.org/10.1111/eva.12076
Published in
Evolutionary Applications
Authors
Ojala, Ville |
Laitalainen, Jarkko |
Jalasvuori, Matti
Date
2013
Discipline
Solu- ja molekyylibiologiaBiologisten vuorovaikutusten huippututkimusyksikköCell and Molecular BiologyCentre of Excellence in Biological Interactions Research

 
The emergence of pathogenic bacteria resistant to multiple antibiotics is a serious worldwide public health concern. Whenever antibiotics are applied, the genes encoding for antibiotic resistance are selected for within bacterial populations. This has led to the prevalence of conjugative plasmids that carry resistance genes and can transfer themselves between diverse bacterial groups. In this study, we investigated whether it is feasible to attempt to prevent the spread of antibiotic resistances with a lytic bacteriophage, which can replicate in a wide range of gram‐negative bacteria harbouring conjugative drug resistance–conferring plasmids. The counter‐selection against the plasmid was shown to be effective, reducing the frequency of multidrug‐resistant bacteria that formed via horizontal transfer by several orders of magnitude. This was true also in the presence of an antibiotic against which the plasmid provided resistance. Majority of the multiresistant bacteria subjected to phage selection also lost their conjugation capability. Overall this study suggests that, while we are obligated to maintain the selection for the spread of the drug resistances, the ‘fight evolution with evolution’ approach could help us even out the outcome to our favour. ...
Publisher
Wiley-Blackwell
ISSN Search the Publication Forum
1752-4571
Keywords
antibioottivastustuskyky sairaalabakteerit faagiterapia hospital bacteria antibioottiresistenssi fagiterapia

Original source
http://onlinelibrary.wiley.com/doi/10.1111/eva.12076/full

DOI
https://doi.org/10.1111/eva.12076
Dataset(s) related to the publication
https://doi.org/10.5061/dryad.4194c
URI

http://urn.fi/URN:NBN:fi:jyu-201310092444

Publication in research information system

https://converis.jyu.fi/converis/portal/detail/Publication/22804203

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  • Matemaattis-luonnontieteellinen tiedekunta [4594]
Additional information about funding
This work was supported by the Academy of Finland Centre of Excellence in Biological Interactions and by Academy of Finland personal grant to MJ.

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