Show simple item record

dc.contributor.authorLensu, Sanna
dc.contributor.authorWaselius, Tomi
dc.contributor.authorMäkinen, Elina
dc.contributor.authorKettunen, Heikki
dc.contributor.authorVirtanen, Ari
dc.contributor.authorTiirola, Marja
dc.contributor.authorPenttonen, Markku
dc.contributor.authorPekkala, Satu
dc.contributor.authorNokia, Miriam S.
dc.date.accessioned2021-01-14T08:20:37Z
dc.date.available2021-01-14T08:20:37Z
dc.date.issued2021
dc.identifier.citationLensu, S., Waselius, T., Mäkinen, E., Kettunen, H., Virtanen, A., Tiirola, M., Penttonen, M., Pekkala, S., & Nokia, M. S. (2021). Irradiation of the head reduces adult hippocampal neurogenesis and impairs spatial memory, but leaves overall health intact in rats. <i>European Journal of Neuroscience</i>, <i>53</i>(6), 1885-1904. <a href="https://doi.org/10.1111/ejn.15102" target="_blank">https://doi.org/10.1111/ejn.15102</a>
dc.identifier.otherCONVID_47673490
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/73611
dc.description.abstractTreatment of brain cancer, glioma, can cause cognitive impairment as a side‐effect, possibly because it disrupts the integrity of the hippocampus, a structure vital for normal memory. Radiotherapy is commonly used to treat glioma, but the effects of irradiation on the brain are still poorly understood, and other biological effects have not been extensively studied. Here we exposed healthy adult male rats to small and moderate‐dose irradiation of the head. We found no effect of irradiation on systemic inflammation, weight gain or gut microbiota diversity, although it increased the abundance of Bacteroidaceae family, namely Bacteroides genus in the gut microbiota. Irradiation had no effect on long‐term potentiation in the CA3‐CA1 synapse or endogenous hippocampal electrophysiology, but it did reduce adult hippocampal neurogenesis and impaired short‐term spatial recognition memory. However, no overall cognitive impairment was observed. To summarize, our results suggest that in adult male rats head irradiation does not compromize health or cognition overall even though the number of new, adult‐born hippocampal neurons is decreased. Thus, the sole effects of head irradiation on the body, brain and cognition might be less harmful than previously thought, and the cognitive decline experienced by cancer patients might originate from physiological and mental effects of the disease itself. Therefore, and to increase the translational value of animal studies, the effects of irradiation should be studied together with cancer, in older animals, using varying irradiation protocols and doses.en
dc.format.mimetypeapplication/pdf
dc.languageeng
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofseriesEuropean Journal of Neuroscience
dc.rightsIn Copyright
dc.subject.otheradult hippocampal neurogenesis
dc.subject.othercancer treatment
dc.subject.othergut microbiota
dc.subject.otherin vivo electrophysiology
dc.subject.otherinflammation
dc.subject.otherlearning
dc.titleIrradiation of the head reduces adult hippocampal neurogenesis and impairs spatial memory, but leaves overall health intact in rats
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-202101141087
dc.contributor.laitosOpettajankoulutuslaitosfi
dc.contributor.laitosPsykologian laitosfi
dc.contributor.laitosBio- ja ympäristötieteiden laitosfi
dc.contributor.laitosFysiikan laitosfi
dc.contributor.laitosLiikuntatieteellinen tiedekuntafi
dc.contributor.laitosDepartment of Teacher Educationen
dc.contributor.laitosDepartment of Psychologyen
dc.contributor.laitosDepartment of Biological and Environmental Scienceen
dc.contributor.laitosDepartment of Physicsen
dc.contributor.laitosFaculty of Sport and Health Sciencesen
dc.contributor.oppiaineLiikuntalääketiedefi
dc.contributor.oppiaineLiikuntafysiologiafi
dc.contributor.oppiainePsykologiafi
dc.contributor.oppiaineYmpäristötiedefi
dc.contributor.oppiaineMonitieteinen aivotutkimuskeskusfi
dc.contributor.oppiaineHyvinvoinnin tutkimuksen yhteisöfi
dc.contributor.oppiaineKäyttäytymisen muutos, hyvinvointi ja terveys elämänkulussafi
dc.contributor.oppiaineAivojen muutokset elinkaaren aikanafi
dc.contributor.oppiaineSports and Exercise Medicineen
dc.contributor.oppiaineExercise Physiologyen
dc.contributor.oppiainePsychologyen
dc.contributor.oppiaineEnvironmental Scienceen
dc.contributor.oppiaineCentre for Interdisciplinary Brain Researchen
dc.contributor.oppiaineSchool of Wellbeingen
dc.contributor.oppiaineBehaviour change, health, and well-being across the lifespanen
dc.contributor.oppiaineBrain changes across the life-spanen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1
dc.description.reviewstatuspeerReviewed
dc.format.pagerange1885-1904
dc.relation.issn0953-816X
dc.relation.numberinseries6
dc.relation.volume53
dc.type.versionacceptedVersion
dc.rights.copyright© Wiley-Blackwell, 2020
dc.rights.accesslevelopenAccessfi
dc.relation.grantnumber286384
dc.relation.grantnumber313334
dc.relation.grantnumber308042
dc.relation.grantnumber275954
dc.relation.grantnumber316966
dc.relation.grantnumber7F36E1
dc.subject.ysosyöpähoidot
dc.subject.ysotulehdus
dc.subject.ysoelektrofysiologia
dc.subject.ysokoe-eläinmallit
dc.subject.ysomuisti (kognitio)
dc.subject.ysosädehoito
dc.subject.ysohippokampus
dc.subject.ysofysiologiset vaikutukset
dc.subject.ysosuolistomikrobisto
dc.subject.ysoneurobiologia
dc.subject.ysosäteilybiologia
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p27422
jyx.subject.urihttp://www.yso.fi/onto/yso/p1049
jyx.subject.urihttp://www.yso.fi/onto/yso/p7871
jyx.subject.urihttp://www.yso.fi/onto/yso/p28104
jyx.subject.urihttp://www.yso.fi/onto/yso/p2607
jyx.subject.urihttp://www.yso.fi/onto/yso/p15892
jyx.subject.urihttp://www.yso.fi/onto/yso/p21117
jyx.subject.urihttp://www.yso.fi/onto/yso/p11511
jyx.subject.urihttp://www.yso.fi/onto/yso/p37925
jyx.subject.urihttp://www.yso.fi/onto/yso/p2967
jyx.subject.urihttp://www.yso.fi/onto/yso/p1781
dc.rights.urlhttp://rightsstatements.org/page/InC/1.0/?language=en
dc.relation.doi10.1111/ejn.15102
dc.relation.funderResearch Council of Finlanden
dc.relation.funderResearch Council of Finlanden
dc.relation.funderResearch Council of Finlanden
dc.relation.funderResearch Council of Finlanden
dc.relation.funderResearch Council of Finlanden
dc.relation.funderJenny and Antti Wihuri Foundationen
dc.relation.funderSuomen Akatemiafi
dc.relation.funderSuomen Akatemiafi
dc.relation.funderSuomen Akatemiafi
dc.relation.funderSuomen Akatemiafi
dc.relation.funderSuomen Akatemiafi
dc.relation.funderJenny ja Antti Wihurin rahastofi
jyx.fundingprogramAcademy Project, AoFen
jyx.fundingprogramResearch costs of Academy Research Fellow, AoFen
jyx.fundingprogramAcademy Research Fellow, AoFen
jyx.fundingprogramAcademy Research Fellow, AoFen
jyx.fundingprogramAcademy Project, AoFen
jyx.fundingprogramFoundationen
jyx.fundingprogramAkatemiahanke, SAfi
jyx.fundingprogramAkatemiatutkijan tutkimuskulut, SAfi
jyx.fundingprogramAkatemiatutkija, SAfi
jyx.fundingprogramAkatemiatutkija, SAfi
jyx.fundingprogramAkatemiahanke, SAfi
jyx.fundingprogramSäätiöfi
jyx.fundinginformationThis work was supported by the Academy of Finland (275954, 286384 and 313334 to M.S.N., 316966 to M.P., and 308042 to S.P.). The foundation of Jenny and Antti Wihuri and the Central Finland Regional fund of the Finnish Cultural Foundation are acknowledged for their personal grants to S.L.
dc.type.okmA1


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record

In Copyright
Except where otherwise noted, this item's license is described as In Copyright