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dc.contributor.authorLensu, Sanna
dc.contributor.authorPariyani, Raghunath
dc.contributor.authorMäkinen, Elina
dc.contributor.authorYang, Baoru
dc.contributor.authorSaleem, Wisam
dc.contributor.authorMunukka, Eveliina
dc.contributor.authorLehti, Maarit
dc.contributor.authorDriuchina, Anastasiia
dc.contributor.authorLindén, Jere
dc.contributor.authorTiirola, Marja
dc.contributor.authorLahti, Leo
dc.contributor.authorPekkala, Satu
dc.date.accessioned2020-10-27T08:40:14Z
dc.date.available2020-10-27T08:40:14Z
dc.date.issued2020
dc.identifier.citationLensu, S., Pariyani, R., Mäkinen, E., Yang, B., Saleem, W., Munukka, E., Lehti, M., Driuchina, A., Lindén, J., Tiirola, M., Lahti, L., & Pekkala, S. (2020). Prebiotic Xylo-Oligosaccharides Ameliorate High-Fat-Diet-Induced Hepatic Steatosis in Rats. <i>Nutrients</i>, <i>12</i>(11), Article 3225. <a href="https://doi.org/10.3390/nu12113225" target="_blank">https://doi.org/10.3390/nu12113225</a>
dc.identifier.otherCONVID_43345829
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/72355
dc.description.abstractUnderstanding the importance of the gut microbiota (GM) in non-alcoholic fatty liver disease (NAFLD) has raised the hope for therapeutic microbes. We have shown that high hepatic fat content associated with low abundance of Faecalibacterium prausnitzii in humans and, further, the administration of F. prausnitzii prevented NAFLD in mice. Here, we aimed at targeting F. prausnitzii by prebiotic xylo-oligosaccharides (XOS) to treat NAFLD. First, the effect of XOS on F. prausnitzii growth was assessed in vitro. Then, XOS was supplemented or not with high (HFD, 60% of energy from fat) or low (LFD) fat diet for 12 weeks in Wistar rats (n = 10/group). XOS increased F. prausnitzii growth, having only a minor impact on the GM composition. When supplemented with HFD, XOS ameliorated hepatic steatosis. The underlying mechanisms involved enhanced hepatic β-oxidation and mitochondrial respiration. Nuclear magnetic resonance (1H-NMR) analysis of cecal metabolites showed that, compared to the HFD, the LFD group had a healthier cecal short-chain fatty acid profile and on the HFD, XOS reduced cecal isovalerate and tyrosine, metabolites previously linked to NAFLD. Cecal branched-chain fatty acids associated positively and butyrate negatively with hepatic triglycerides. In conclusion, XOS supplementation can ameliorate NAFLD by improving hepatic oxidative metabolism and affecting GM.en
dc.format.mimetypeapplication/pdf
dc.languageeng
dc.language.isoeng
dc.publisherMDPI AG
dc.relation.ispartofseriesNutrients
dc.rightsCC BY 4.0
dc.subject.otherprebiotic
dc.subject.otheroligosaccharides
dc.subject.othergut microbiota
dc.subject.otherfatty liver
dc.subject.othermetabolism
dc.subject.othermitochondria
dc.titlePrebiotic Xylo-Oligosaccharides Ameliorate High-Fat-Diet-Induced Hepatic Steatosis in Rats
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-202010276404
dc.contributor.laitosLiikuntatieteellinen tiedekuntafi
dc.contributor.laitosBio- ja ympäristötieteiden laitosfi
dc.contributor.laitosFaculty of Sport and Health Sciencesen
dc.contributor.laitosDepartment of Biological and Environmental Scienceen
dc.contributor.oppiaineYmpäristötiedefi
dc.contributor.oppiaineLiikuntalääketiedefi
dc.contributor.oppiaineLiikuntafysiologiafi
dc.contributor.oppiaineEnvironmental Scienceen
dc.contributor.oppiaineSports and Exercise Medicineen
dc.contributor.oppiaineExercise Physiologyen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1
dc.description.reviewstatuspeerReviewed
dc.relation.issn2072-6643
dc.relation.numberinseries11
dc.relation.volume12
dc.type.versionpublishedVersion
dc.rights.copyright© 2020 by the authors. Licensee MDPI, Basel, Switzerland
dc.rights.accesslevelopenAccessfi
dc.relation.grantnumber308042
dc.subject.ysorasvamaksa
dc.subject.ysosuolistomikrobisto
dc.subject.ysooligosakkaridit
dc.subject.ysoaineenvaihduntatuotteet
dc.subject.ysoprebiootit
dc.subject.ysoaineenvaihdunta
dc.subject.ysomitokondriot
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p21481
jyx.subject.urihttp://www.yso.fi/onto/yso/p37925
jyx.subject.urihttp://www.yso.fi/onto/yso/p21907
jyx.subject.urihttp://www.yso.fi/onto/yso/p24583
jyx.subject.urihttp://www.yso.fi/onto/yso/p24181
jyx.subject.urihttp://www.yso.fi/onto/yso/p3066
jyx.subject.urihttp://www.yso.fi/onto/yso/p21158
dc.rights.urlhttps://creativecommons.org/licenses/by/4.0/
dc.relation.doi10.3390/nu12113225
dc.relation.funderResearch Council of Finlanden
dc.relation.funderSuomen Akatemiafi
jyx.fundingprogramAcademy Research Fellow, AoFen
jyx.fundingprogramAkatemiatutkija, SAfi
jyx.fundinginformationThis study was financially supported by the Academy of Finland Researcher fellowship for Pekkala (Grant ID 308042) and by the ERVA funding of The Hospital District of Southwest Finland for Pekkala. The foundation of Jenny and Antti Wihuri and the Central Finland Regional fund of the Finnish Cultural Foundation are acknowledged for their personal grants to S.L. to perform this study.
dc.type.okmA1


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