Fecal Metagenomics and Metabolomics Identifying Microbial Signatures in Non-Alcoholic Fatty Liver Disease
Pekkala, S. (2023). Fecal Metagenomics and Metabolomics Identifying Microbial Signatures in Non-Alcoholic Fatty Liver Disease. International Journal of Molecular Sciences, 24(5), 4855. https://doi.org/10.3390/ijms24054855
Julkaistu sarjassa
International Journal of Molecular SciencesTekijät
Päivämäärä
2023Tekijänoikeudet
© 2023 the Authors
The frequency of non-alcoholic fatty liver disease (NAFLD) has intensified, creating diagnostic challenges and increasing the need for reliable non-invasive diagnostic tools. Due to the importance of the gut–liver axis in the progression of NAFLD, studies attempt to reveal microbial signatures in NAFLD, evaluate them as diagnostic biomarkers, and to predict disease progression. The gut microbiome affects human physiology by processing the ingested food into bioactive metabolites. These molecules can penetrate the portal vein and the liver to promote or prevent hepatic fat accumulation. Here, the findings of human fecal metagenomic and metabolomic studies relating to NAFLD are reviewed. The studies present mostly distinct, and even contradictory, findings regarding microbial metabolites and functional genes in NAFLD. The most abundantly reproducing microbial biomarkers include increased lipopolysaccharides and peptidoglycan biosynthesis, enhanced degradation of lysine, increased levels of branched chain amino acids, as well as altered lipid and carbohydrate metabolism. Among other causes, the discrepancies between the studies may be related to the obesity status of the patients and the severity of NAFLD. In none of the studies, except for one, was diet considered, although it is an important factor driving gut microbiota metabolism. Future studies should consider diet in these analyses.
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Julkaisija
MDPI AGISSN Hae Julkaisufoorumista
1661-6596Asiasanat
Julkaisu tutkimustietojärjestelmässä
https://converis.jyu.fi/converis/portal/detail/Publication/177170641
Metadata
Näytä kaikki kuvailutiedotKokoelmat
- Liikuntatieteiden tiedekunta [3139]
Rahoittaja(t)
Suomen AkatemiaRahoitusohjelmat(t)
Profilointi, SA; Akatemiahanke, SALisätietoja rahoituksesta
This study was supported by the Academy of Finland Profi5 (#301824) funding (Physical ACTivity and health during the human life-Span 2; PACTS2) to the University of Jyväskylä and by an Academy of Finland grant to S.P. (grant ID 349264)Lisenssi
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